Discovery of a novel class of orally active antifungal β-1,3-D-glucan synthase inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 11, 2011, Pages 5099-5106

  Walker, Scott S ^a   Xu, Yiming ^a   Triantafyllou, Ilias ^a   Waldman, Michelle F ^a   Mendrick, Cara ^a   Brown, Nathaniel ^a   Mann, Paul ^a   Chau, Andrew ^a   Patel, Reena ^a   Bauman, Nicholas ^a   Norris, Christine ^a   Antonacci, Barry ^a   Gurnani, Maya ^a   Cacciapuoti, Anthony ^a   McNicholas, Paul M ^a   Wainhaus, Samuel ^a   Herr, R Jason ^b   Kuang, Rongze ^a   Aslanian, Robert G ^a   Ting, Pauline C ^a   Black, Todd A ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BETA 1,3 DEXTRO GLUCAN SYNTHASE INHIBITOR; ECHINOCANDIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA GLABRATA; CANDIDIASIS; CYTOPLASM; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYCOSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDA GLABRATA; CANDIDIASIS; GLUCOSYLTRANSFERASES; MALE; MICE; MOLECULAR STRUCTURE; PIPERAZINES; PYRIDAZINES; SACCHAROMYCES CEREVISIAE;

EID: 80054701122     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00432-11     Document Type: Article

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