Discovery of novel antifungal (1,3)-β-D-glucan synthase inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 2, 2000, Pages 368-377

  Onishi, J ^a,b   Meinz, M ^a   Thompson, J ^a   Curotto, J ^a   Dreikorn, S ^a   Rosenbach, M ^a   Douglas, C ^a   Abruzzo, G ^a   Flattery, A ^a   Kong, L ^a   Cabello, A ^c   Vicente, F ^c   Pelaez, F ^c   Diez, M T ^c   Martin, I ^c   Bills, G ^b   Giacobbe, R ^b   Dombrowski, A ^b   Schwartz, R ^b   Morris, S ^b   Harris, G ^b   Tsipouras, A ^b   Wilson, K ^b   Kurtz, M B ^a   more..

^a Departments of Infectious Diseases   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Centro de Investigacion Basica   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; ANTIFUNGAL AGENT; ARUNDIFUNGIN; ASCOSTEROSIDE; CASPOFUNGIN; DIGITONIN; ECHINOCANDIN B DERIVATIVE; ENFUMAFUNGIN; ENZYME INHIBITOR; ERGOKONIN A; L 733560; NIKKOMYCIN; PAPULACANDIN DERIVATIVE; PNEUMOCANDIN DERIVATIVE; TUNICAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; CANDIDA; CARBOHYDRATE SYNTHESIS; CELL STRUCTURE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; FUNGICIDAL ACTIVITY; METABOLIC INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STRAIN DIFFERENCE;

ANTIFUNGAL AGENTS; CANDIDA ALBICANS; ENZYME INHIBITORS; FUNGAL PROTEINS; GLUCANS; GLUCOSYLTRANSFERASES; MEMBRANE PROTEINS; MUTATION; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS; TERPENES;

EID: 0033966183     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.2.368-377.2000     Document Type: Article

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