Suppression of Etk/Bmx protects against ischemic brain injury

Cell Transplantation

Volumn 21, Issue 1, 2012, Pages 345-354

  Chen, Kai Yun ^a,b   Wu, Chung Che ^a,c   Chang, Cheng Fu ^d   Chen, Yuan Hao ^d   Chiu, Wen Ta ^a,b   Lou, Ya Hsin ^d   Chen, Yen Hua ^a,b   Shih, Hsiu Ming ^e   Chiang, Yung Hsiao ^a,b  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^e INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Apoptosis; Cerebral ischemia; Etk bmx; Stat1

Indexed keywords

CASPASE 3; EPITHELIAL AND ENDOTHELIAL TYROSINE KINASE; HYDROGEN PEROXIDE; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; NEUROPROTECTION; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMIDES; ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CASPASE 3; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CEREBRAL CORTEX; HYDROGEN PEROXIDE; NEURONS; NITRILES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RATS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

RATTUS;

EID: 84863284742     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368911X582741     Document Type: Article

References (40)

1. Avshalumov, M. V.; Rice, M. E. NMDA receptor activation mediates hydrogen peroxide-induced pathophysiology in rat hippocampal slices. J. Neurophysiol. 87(6):2896-2903; 2002.
2. 2-induced activation of transcription factors STATl and STAT3: The role of EGF receptor and tyrosine kinase JAK2. Tsitologiia 43(12):1153-1161; 200l.
3. Chau, C. H.; Chen, K. Y.; Deng, H. T.; Kim, K. J.; Hosoya, K.; Terasaki, T.; Shih, H. M.; Ann, D. K. Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation. Oncogene 21(57): 88l7-8829; 2002.
4. Chen, K. Y.; Huang, L. M.; Kung, H. J.; Ann, D. K.; Shih, H. M. The role of tyrosine kinase Etk/Bmx in EGF- induced apoptosis of MDA-MB-468 breast cancer cells. Oncogene 23(10):l854-l862; 2004.
5. Chen, R.; Kim, O.; Li, M.; Xiong, X.; Guan, J. L.; Kung, H. J.; Chen, H.; Shimizu, Y.; Qiu, Y. Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat. Cell Biol. 3(5):439-444; 2001.
6. Deb, P.; Sharma, S.; Hassan, K. M. Pathophysiologic mechanisms of acute ischemic stroke: An overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology 17(3):197-218; 2010.
7. Emerich, D. F.; Silva, E.; Ali, O.; Mooney, D.; Bell, W.; Yu, S. J.; Kaneko, Y.; Borlongan, C. Injectable VEGF hydrogels produce near complete neurological and anatomical protection following cerebral ischemia in rats. Cell Transplant. 19(9):1063-1071; 2010.
8. Ferrer, I.; Planas, A. M. Signaling of cell death and cell survival following focal cerebral ischemia: Life and death struggle in the penumbra. J. Neuropathol. Exp. Neurol. 62(4):329-339; 2003.
9. Guo, L.; Chen, P.; Zhou, Y.; Sun, Y. Non-receptor tyrosine kinase Etk is involved in the apoptosis of small cell lung cancer cells. Exp. Mol. Pathol. 88(3):401-406; 2010.
10. Guo, L.; Guo, Y.; Xiao, S. Expression of Etk/Bmx tyrosine kinase in intrahepatic cholangiocarcinoma. J. Surg. Oncol. 97(5):428-432; 2008.
11. Jiang, T.; Guo, Z.; Dai, B.; Kang, M.; Ann, D. K.; Kung, H. J.; Qiu, Y. Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage. J. Biol. Chem. 279(48):50181-50189; 2004.
12. Johnson, Jr., E. M.; Greenlund, L. J.; Akins, P. T.; Hsu, C. Y. Neuronal apoptosis: Current understanding of molecular mechanisms and potential role in ischemic brain injury. J. Neurotrauma 12(5):843-852; 1995.
13. Kiessling, M.; Gass, P. Stimulus-transcription coupling in focal cerebral ischemia. Brain Pathol. 4(1):77-83; 1994.
14. Li, Y.; Chopp, M.; Powers, C.; Jiang, N. Apoptosis and protein expression after focal cerebral ischemia in rat. Brain Res. 765(2):301-312; 1997.
15. Linnik, M. D.; Zobrist, R. H.; Hatfield, M. D. Evidence supporting a role for programmed cell death in focal cere-bral ischemia in rats. Stroke 24(12):2002-2009; 1993.
16. Mehta, S. L.; Manhas, N.; Raghubir, R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res. Rev. 54(1):34-66; 2007.
17. Nakka, V. P.; Gusain, A.; Mehta, S. L.; Raghubir, R. Molecular mechanisms of apoptosis in cerebral ischemia: Multiple neuroprotective opportunities. Mol. Neurobiol. 37(1):7-38; 2008.
18. Paavonen, K.; Ekman, N.; Wirzenius, M.; Rajantie, I.; Poutanen, M.; Alitalo, K. Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Mol. Biol. Cell 15(9):4226-4233; 2004.
19. Palmer, C. D.; Mutch, B. E.; Workman, S.; McDaid, J. P.; Horwood, N. J.; Foxwell, B. M. Bmx tyrosine kinase reg-ulates TLR4-induced IL-6 production in human macro-phages independently of p38 MAPK and NFkappaB activity. Blood 111(4):1781-1788; 2008.
20. Park, D. H.; Borlongan, C. V.; Willing, A. E.; Eve, D. J.; Cruz, L. E.; Sanberg, C. D.; Chung, Y. G.; Sanberg, P. R. Human umbilical cord blood cell grafts for brain ischemia. Cell Transplant. 18(9):985-998; 2009.
21. Planas, A. M.; Gorina, R.; Chamorro, A. Signalling path-ways mediating inflammatory responses in brain isch- aemia. Biochem. Soc. Trans. 34(Pt. 6):1267-1270; 2006.
22. Qiu, Y.; Kung, H. J. Signaling network of the Btk family kinases. Oncogene 19(49):5651-5661; 2000.
23. Qiu, Y.; Robinson, D.; Pretlow, T. G.; Kung, H. J. Etk/ Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. Proc. Natl. Acad. Sci. USA 95(7):3644-3649; 1998.
24. Repici, M.; Mariani, J.; Borsello, T. Neuronal death and neuroprotection: A review. Methods Mol. Biol. 399: 1-14; 2007.
25. Rubinson, D. A.; Dillon, C. P.; Kwiatkowski, A. V.; Sievers, C.; Yang, L.; Kopinja, J.; Rooney, D. L.; Zhang, M.; Ihrig, M. M.; McManus, M. T.; Gertler, F. B.; Scott, M. L.; Van Parijs, L. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33(3):401-406; 2003.
26. Saeed, S. A.; Shad, K. F.; Saleem, T.; Javed, F.; Khan, M. U. Some new prospects in the understanding of the molecular basis of the pathogenesis of stroke. Exp. Brain Res. 182(1):1-10; 2007.
27. Saito, Y.; Goto, M.; Maya, K.; Ogawa, N.; Fujimori, K.; Kurokawa, Y.; Satomi, S. Brain death in combination with warm ischemic stress during isolation procedures induces the expression of crucial inflammatory mediators in the isolated islets. Cell Transplant. 19(6):775-782; 2010.
28. Schmued, L. C.; Hopkins, K. J. Fluoro-Jade: Novel fluo- rochromes for detecting toxicant-induced neuronal degen-eration. Toxicol. Pathol. 28(1):91-99; 2000.
29. Shi, H.; Liu, K. J. Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion. Front. Biosci. 12:1318-1328; 2007.
30. Stephanou, A. Role of STAT-1 and STAT-3 in ischaemia/ reperfusion injury. J. Cell. Mol. Med. 8(4):519-525; 2004.
31. Tacchini, L.; Fusar-Poli, D.; Bernelli-Zazzera, A. Activation of transcription factors by drugs inducing oxidative stress in rat liver. Biochem. Pharmacol. 63(2):139-148; 2002.
32. Tsai, Y. T.; Su, Y. H.; Fang, S. S.; Huang, T. N.; Qiu, Y.; Jou, Y. S.; Shih, H. M.; Kung, H. J.; Chen, R. H. Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. Mol. Cell. Biol. 20(6):2043-2054; 2000.
33. Tuttolomondo, A.; Di Raimondo, D.; di Sciacca, R.; Pinto, A.; Licata, G. Inflammatory cytokines in acute ischemic stroke. Curr. Pharm. Des. 14(33):3574-3589; 2008.
34. Wang, Y.; Chang, C. F.; Morales, M.; Chou, J.; Chen, H. L.; Chiang, Y. H.; Lin, S. Z.; Cadet, J. L.; Deng, X.; Wang, J. Y.; Chen, S. Y.; Kaplan, P. L.; Hoffer, B. J. Bone morphogenetic protein-6 reduces ischemia-induced brain damage in rats. Stroke 32(9):2170-2178; 2001.
35. Wang, Y.; Lin, S. Z.; Chiou, A. L.; Williams, L. R.; Hoffer, B. J. Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex. J. Neurosci. 17(11):4341-4348; 1997.
36. West, D. A.; Valentim, L. M.; Lythgoe, M. F.; Stephanou, A.; Proctor, E.; van der Weerd, L.; Ordidge, R. J.; Latchman, D. S.; Gadian, D. G. MR image-guided investigation of regional signal transducers and activators of transcription- 1 activation in a rat model of focal cerebral ischemia. Neuroscience 127(2):333-339; 2004.
37. Wu, Y. M.; Huang, C. L.; Kung, H. J.; Huang, C. Y. Pro-teolytic activation of ETK/Bmx tyrosine kinase by cas- pases. J. Biol. Chem. 276(21):17672-17678; 2001.
38. Xue, L. Y.; Qiu, Y.; He, J.; Kung, H. J.; Oleinick, N. L. Etk/Bmx, a PH-domain containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by pho-todynamic therapy or thapsigargin. Oncogene 18(22): 3391-3398; 1999.
39. Yamashita, T.; Deguchi, K.; Nagotani, S.; Kamiya, T.; Abe, K. Gene and stem cell therapy in ischemic stroke. Cell Transplant. 18(9):999-1002; 2009.
40. Zhang, J.; Ping, P.; Wang, G. W.; Lu, M.; Pantaleon, D.; Tang, X. L.; Bolli, R.; Vondriska, T. M. Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection. Am. J. Physiol. Heart Circ. Physiol. 287(5):H2364-2366; 2004.