Chiral Mercaptoacetamides Display Enantioselective Inhibition of Histone Deacetylase6 and Exhibit Neuroprotection in Cortical Neuron Models of Oxidative Stress

ChemMedChem

Volumn 7, Issue 3, 2012, Pages 425-439

  Kalin, Jay H ^a   Zhang, Hankun ^a   Gaudrel Grosay, Sophie ^a   Vistoli, Giulio ^b   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Dimerization; Enantioselectivity; Histone deacetylases; Mercaptoacetamides; Neurological agents

Indexed keywords

2 (7 (5 METHYL 3 PHENYLISOXAZOL 4 YL)HEPT 6 ENYLAMINO) 2 OXOETHYL 2,2 DIMETHYLPROPANETHIOATE; 2 MERCAPTO N (7 (5 METHYL 3 PHENYLISOXAZOL 4 YL)HEPT 6 ENYL)ACETAMIDE; 2 TRITYLSULFANYLISOBUTYRIC ACID; 2 TRITYLSULFANYLPROPIONIC ACID; 5 METHYL 3 PHENYLISOXAZOL 4 YLMETHANOL; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBALDEHYDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID (6 HYDROXYCARBAMOYLHEXYL)AMIDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID [5 (2 MERCAPTOACETYL)AMINOPENTYL]AMIDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID [5 (2 MERCAPTOISOBUTYRYL)AMINOPENTYL]AMIDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID [5 (2 MERCAPTOPROPIONYL)AMINOPENTYL]AMIDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID [5 (2 PIVALOYLSULFANYLACETYL)AMINOPENTYL]AMIDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID [5 (2 TRITYLSULFANYLACETYL)AMINOPENTYL]AMIDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID [5 (2 TRITYLSULFANYLISOBUTYRYL)AMINOPENTYL]AMIDE; 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID [5 (2 TRITYLSULFANYLPROPIONYL)AMINOPENTYL]AMIDE; ETHYL 5 METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLATE; HISTONE DEACETYLASE INHIBITOR; METHYL 3 PHENYLISOXAZOLE 4 CARBOXYLIC ACID (5 AMINOPENTYL)AMIDE; METHYL 7 (5 METHYL 3 PHENYLISOXAZOLE 4 CARBONYLAMINO)HEPTANOATE; N [5 [(5 METHYL 3 PHENYLISOXAZOL 4 YL)METHOXY]PENTYL] 2 (TRITYLTHIO)PROPANAMIDE; N [7 (5 METHYL 3 PHENYLISOXAZOL 4 YL)HEPT 6 ENYL] 2 MERCAPTOACETAMIDE; N [7 (5 METHYL 3 PHENYLISOXAZOL 4 YL)HEPT 6 ENYL] 2 MERCAPTOISOBUTYRAMIDE; N [7 (5 METHYL 3 PHENYLISOXAZOL 4 YL)HEPT 6 ENYL] 2 MERCAPTOPROPIONAMIDE; N [7 (5 METHYL 3 PHENYLISOXAZOL 4 YL)HEPT 6 ENYL] 2 PIVALOYLSULFANYLACETAMIDE; NEUROPROTECTIVE AGENT; PIVALOYLSULFANYLACETIC ACID; TERT BUTYL 5 (5 METHYL 3 PHENYLISOXAZOL 4 YLMETHOXY)PENTYLCARBAMATE; TERT BUTYL 5 (5 METHYL 3 PHENYLISOXAZOLE 4 CARBONYLAMINO)PENTYLCARBAMATE; TERT BUTYL 7 (5 METHYL 3 PHENYLISOXAZOL 4 YL)HEPT 6 ENYLCARBAMATE; TRITYLSULFANYLACETIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL DEATH; CHIRALITY; CONTROLLED STUDY; DIMERIZATION; DRUG POTENCY; ENANTIOSELECTIVITY; IN VITRO STUDY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ANIMALS; DIMERIZATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MODELS, MOLECULAR; NEURODEGENERATIVE DISEASES; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PRIMARY CELL CULTURE; PROTEIN ISOFORMS; RATS; STEREOISOMERISM; SULFHYDRYL COMPOUNDS;

EID: 84863275305     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100522     Document Type: Article

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