-
1
-
-
70349912439
-
Crystal structures of penicillin-binding protein 6 from Escherichia coli
-
Chen, Y.; Zhang, W.; Shi, Q.; Hesek, D.; Lee, M.; Mobashery, S.; Shoichet, B. K. Crystal structures of penicillin-binding protein 6 from Escherichia coli J. Am. Chem. Soc. 2009, 131, 14345-14354
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 14345-14354
-
-
Chen, Y.1
Zhang, W.2
Shi, Q.3
Hesek, D.4
Lee, M.5
Mobashery, S.6
Shoichet, B.K.7
-
2
-
-
77957809929
-
The future of the beta-lactams
-
Llarrull, L. I.; Testero, S. A.; Fisher, J. F.; Mobashery, S. The future of the beta-lactams Curr. Opin. Microbiol. 2010, 13, 551-557
-
(2010)
Curr. Opin. Microbiol.
, vol.13
, pp. 551-557
-
-
Llarrull, L.I.1
Testero, S.A.2
Fisher, J.F.3
Mobashery, S.4
-
3
-
-
0013808622
-
Mechanism of action of penicillins: A proposal based on their structural similarity to acyl- d -alanyl- d -alanine
-
Tipper, D. J.; Strominger, J. L. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl- d -alanyl- d -alanine Proc. Natl. Acad. Sci. U.S.A. 1965, 54, 1133-1141
-
(1965)
Proc. Natl. Acad. Sci. U.S.A.
, vol.54
, pp. 1133-1141
-
-
Tipper, D.J.1
Strominger, J.L.2
-
4
-
-
0037432016
-
The crystal structure of phosphonate-inhibited d -Ala- d -Ala peptidase reveals an analogue of a tetrahedral transition state
-
Silvaggi, N. R.; Anderson, J. W.; Brinsmade, S. R.; Pratt, R. F.; Kelly, J. A. The crystal structure of phosphonate-inhibited d -Ala- d -Ala peptidase reveals an analogue of a tetrahedral transition state Biochemistry 2003, 42, 1199-1208
-
(2003)
Biochemistry
, vol.42
, pp. 1199-1208
-
-
Silvaggi, N.R.1
Anderson, J.W.2
Brinsmade, S.R.3
Pratt, R.F.4
Kelly, J.A.5
-
5
-
-
0029019031
-
Beta-lactamases and bacterial resistance to antibiotics
-
Frere, J. M. Beta-lactamases and bacterial resistance to antibiotics Mol. Microbiol. 1995, 16, 385-395
-
(1995)
Mol. Microbiol.
, vol.16
, pp. 385-395
-
-
Frere, J.M.1
-
6
-
-
14844362964
-
Bacterial resistance to beta-lactam antibiotics: Compelling opportunism, compelling opportunity
-
Fisher, J. F.; Meroueh, S. O.; Mobashery, S. Bacterial resistance to beta-lactam antibiotics: compelling opportunism, compelling opportunity Chem. Rev. 2005, 105, 395-424
-
(2005)
Chem. Rev.
, vol.105
, pp. 395-424
-
-
Fisher, J.F.1
Meroueh, S.O.2
Mobashery, S.3
-
7
-
-
47749093130
-
The bacteria fight back
-
Taubes, G. The bacteria fight back Science 2008, 321, 356-361
-
(2008)
Science
, vol.321
, pp. 356-361
-
-
Taubes, G.1
-
8
-
-
0029071785
-
A functional classification scheme for beta-lactamases and its correlation with molecular structure
-
Bush, K.; Jacoby, G. A.; Medeiros, A. A. A functional classification scheme for beta-lactamases and its correlation with molecular structure Antimicrob. Agents Chemother. 1995, 39, 1211-1233
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1211-1233
-
-
Bush, K.1
Jacoby, G.A.2
Medeiros, A.A.3
-
9
-
-
0028883511
-
Beta-Lactamases in laboratory and clinical resistance
-
Livermore, D. M. beta-Lactamases in laboratory and clinical resistance Clin. Microbiol. Rev. 1995, 8, 557-584
-
(1995)
Clin. Microbiol. Rev.
, vol.8
, pp. 557-584
-
-
Livermore, D.M.1
-
10
-
-
16244415566
-
Atomic resolution structures of CTX-M beta-lactamases: Extended spectrum activities from increased mobility and decreased stability
-
Chen, Y.; Delmas, J.; Sirot, J.; Shoichet, B.; Bonnet, R. Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability J. Mol. Biol. 2005, 348, 349-362
-
(2005)
J. Mol. Biol.
, vol.348
, pp. 349-362
-
-
Chen, Y.1
Delmas, J.2
Sirot, J.3
Shoichet, B.4
Bonnet, R.5
-
11
-
-
77953729075
-
Structural insights into substrate recognition and product expulsion in CTX-M enzymes
-
Delmas, J.; Leyssene, D.; Dubois, D.; Birck, C.; Vazeille, E.; Robin, F.; Bonnet, R. Structural insights into substrate recognition and product expulsion in CTX-M enzymes J. Mol. Biol. 2010, 400, 108-120
-
(2010)
J. Mol. Biol.
, vol.400
, pp. 108-120
-
-
Delmas, J.1
Leyssene, D.2
Dubois, D.3
Birck, C.4
Vazeille, E.5
Robin, F.6
Bonnet, R.7
-
12
-
-
17644390560
-
Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases
-
Chen, Y.; Shoichet, B.; Bonnet, R. Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases J. Am. Chem. Soc. 2005, 127, 5423-5434
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 5423-5434
-
-
Chen, Y.1
Shoichet, B.2
Bonnet, R.3
-
13
-
-
0347362476
-
Growing group of extended-spectrum beta-lactamases: The CTX-M enzymes
-
Bonnet, R. Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes Antimicrob. Agents Chemother. 2004, 48, 1-14
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 1-14
-
-
Bonnet, R.1
-
14
-
-
0034763241
-
Extended-spectrum beta-lactamases in the 21st century: Characterization, epidemiology, and detection of this important resistance threat
-
Bradford, P. A. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat Clin. Microbiol. Rev. 2001, 14, 933-951
-
(2001)
Clin. Microbiol. Rev.
, vol.14
, pp. 933-951
-
-
Bradford, P.A.1
-
15
-
-
74249108028
-
Three decades of beta-lactamase inhibitors
-
Drawz, S. M.; Bonomo, R. A. Three decades of beta-lactamase inhibitors Clin. Microbiol. Rev. 2010, 23, 160-201
-
(2010)
Clin. Microbiol. Rev.
, vol.23
, pp. 160-201
-
-
Drawz, S.M.1
Bonomo, R.A.2
-
16
-
-
0027513336
-
Molecular basis of beta-lactamase induction in bacteria
-
Bennett, P. M.; Chopra, I. Molecular basis of beta-lactamase induction in bacteria Antimicrob. Agents Chemother. 1993, 37, 153-158
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 153-158
-
-
Bennett, P.M.1
Chopra, I.2
-
17
-
-
0343632366
-
Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria
-
Jacobs, C.; Frere, J. M.; Normark, S. Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria Cell 1997, 88, 823-832
-
(1997)
Cell
, vol.88
, pp. 823-832
-
-
Jacobs, C.1
Frere, J.M.2
Normark, S.3
-
18
-
-
0031670104
-
Beta-Lactamases: Protein evolution in real time
-
Petrosino, J.; Cantu, C., III; Palzkill, T. beta-Lactamases: protein evolution in real time Trends Microbiol. 1998, 6, 323-327
-
(1998)
Trends Microbiol.
, vol.6
, pp. 323-327
-
-
Petrosino, J.1
Cantu III, C.2
Palzkill, T.3
-
19
-
-
62849121696
-
Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates
-
Pages, J. M.; Lavigne, J. P.; Leflon-Guibout, V.; Marcon, E.; Bert, F.; Noussair, L.; Nicolas-Chanoine, M. H. Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates PLoS ONE 2009, 4, e4817
-
(2009)
PLoS ONE
, vol.4
, pp. 4817
-
-
Pages, J.M.1
Lavigne, J.P.2
Leflon-Guibout, V.3
Marcon, E.4
Bert, F.5
Noussair, L.6
Nicolas-Chanoine, M.H.7
-
20
-
-
4444347175
-
In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor
-
Bonnefoy, A.; Dupuis-Hamelin, C.; Steier, V.; Delachaume, C.; Seys, C.; Stachyra, T.; Fairley, M.; Guitton, M.; Lampilas, M. In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor J. Antimicrob. Chemother. 2004, 54, 410-417
-
(2004)
J. Antimicrob. Chemother.
, vol.54
, pp. 410-417
-
-
Bonnefoy, A.1
Dupuis-Hamelin, C.2
Steier, V.3
Delachaume, C.4
Seys, C.5
Stachyra, T.6
Fairley, M.7
Guitton, M.8
Lampilas, M.9
-
21
-
-
69749123316
-
Inhibition of class A and C beta-lactamases by diaroyl phosphates
-
Majumdar, S.; Pratt, R. F. Inhibition of class A and C beta-lactamases by diaroyl phosphates Biochemistry 2009, 48, 8285-8292
-
(2009)
Biochemistry
, vol.48
, pp. 8285-8292
-
-
Majumdar, S.1
Pratt, R.F.2
-
22
-
-
0037460187
-
Nanomolar inhibitors of AmpC beta-lactamase
-
Morandi, F.; Caselli, E.; Morandi, S.; Focia, P. J.; Blazquez, J.; Shoichet, B. K.; Prati, F. Nanomolar inhibitors of AmpC beta-lactamase J. Am. Chem. Soc. 2003, 125, 685-695
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 685-695
-
-
Morandi, F.1
Caselli, E.2
Morandi, S.3
Focia, P.J.4
Blazquez, J.5
Shoichet, B.K.6
Prati, F.7
-
23
-
-
0029760859
-
Structure-based design of a potent transition state analogue for TEM-1 beta-lactamase
-
Strynadka, N. C.; Martin, R.; Jensen, S. E.; Gold, M.; Jones, J. B. Structure-based design of a potent transition state analogue for TEM-1 beta-lactamase Nature Struct. Biol. 1996, 3, 688-695
-
(1996)
Nature Struct. Biol.
, vol.3
, pp. 688-695
-
-
Strynadka, N.C.1
Martin, R.2
Jensen, S.E.3
Gold, M.4
Jones, J.B.5
-
24
-
-
16844378060
-
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture
-
Tondi, D.; Morandi, F.; Bonnet, R.; Costi, M. P.; Shoichet, B. K. Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture J. Am. Chem. Soc. 2005, 127, 4632-4639
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 4632-4639
-
-
Tondi, D.1
Morandi, F.2
Bonnet, R.3
Costi, M.P.4
Shoichet, B.K.5
-
25
-
-
65349195698
-
Molecular docking and ligand specificity in fragment-based inhibitor discovery
-
Chen, Y.; Shoichet, B. K. Molecular docking and ligand specificity in fragment-based inhibitor discovery Nature Chem. Biol. 2009, 5, 358-364
-
(2009)
Nature Chem. Biol.
, vol.5
, pp. 358-364
-
-
Chen, Y.1
Shoichet, B.K.2
-
27
-
-
67650299761
-
Quantifying biogenic bias in screening libraries
-
Hert, J.; Irwin, J. J.; Laggner, C.; Keiser, M. J.; Shoichet, B. K. Quantifying biogenic bias in screening libraries Nature Chem. Biol. 2009, 5, 479-483
-
(2009)
Nature Chem. Biol.
, vol.5
, pp. 479-483
-
-
Hert, J.1
Irwin, J.J.2
Laggner, C.3
Keiser, M.J.4
Shoichet, B.K.5
-
28
-
-
43949129098
-
Physicochemical properties of antibacterial compounds: Implications for drug discovery
-
O'Shea, R.; Moser, H. E. Physicochemical properties of antibacterial compounds: implications for drug discovery J. Med. Chem. 2008, 51, 2871-2878
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2871-2878
-
-
O'Shea, R.1
Moser, H.E.2
-
29
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
Payne, D. J.; Gwynn, M. N.; Holmes, D. J.; Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery Nature Rev. Drug Discovery 2007, 6, 29-40
-
(2007)
Nature Rev. Drug Discovery
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
30
-
-
34247857459
-
The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution
-
Chen, Y.; Bonnet, R.; Shoichet, B. K. The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution J. Am. Chem. Soc. 2007, 129, 5378-5380
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 5378-5380
-
-
Chen, Y.1
Bonnet, R.2
Shoichet, B.K.3
-
31
-
-
23844444239
-
Hierarchical docking of databases of multiple ligand conformations
-
Lorber, D. M.; Shoichet, B. K. Hierarchical docking of databases of multiple ligand conformations Curr. Top. Med. Chem. 2005, 5, 739-749
-
(2005)
Curr. Top. Med. Chem.
, vol.5
, pp. 739-749
-
-
Lorber, D.M.1
Shoichet, B.K.2
-
32
-
-
13844312649
-
ZINC-a free database of commercially available compounds for virtual screening
-
Irwin, J. J.; Shoichet, B. K. ZINC-a free database of commercially available compounds for virtual screening J. Chem. Inf. Model. 2005, 45, 177-182
-
(2005)
J. Chem. Inf. Model.
, vol.45
, pp. 177-182
-
-
Irwin, J.J.1
Shoichet, B.K.2
-
33
-
-
67649962669
-
Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A lipophilic efficiency (LipE) analysis
-
Ryckmans, T.; Edwards, M. P.; Horne, V. A.; Correia, A. M.; Owen, D. R.; Thompson, L. R.; Tran, I.; Tutt, M. F.; Young, T. Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: a lipophilic efficiency (LipE) analysis Bioorg. Med. Chem. Lett. 2009, 19, 4406-4409
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 4406-4409
-
-
Ryckmans, T.1
Edwards, M.P.2
Horne, V.A.3
Correia, A.M.4
Owen, D.R.5
Thompson, L.R.6
Tran, I.7
Tutt, M.F.8
Young, T.9
-
34
-
-
84924572198
-
Performance Standards for Antimicrobial Susceptibility Testing; 20th Informational Supplement
-
10020
-
Wayne, P. Performance Standards for Antimicrobial Susceptibility Testing; 20th Informational Supplement Clin. Lab. Stand. Inst. 2010, M100-S20, 1-23
-
(2010)
Clin. Lab. Stand. Inst.
, pp. 1-23
-
-
Wayne, P.1
-
35
-
-
0041818050
-
Crystal structure of extended-spectrum beta-lactamase Toho-1: Insights into the molecular mechanism for catalytic reaction and substrate specificity expansion
-
Ibuka, A. S.; Ishii, Y.; Galleni, M.; Ishiguro, M.; Yamaguchi, K.; Frere, J. M.; Matsuzawa, H.; Sakai, H. Crystal structure of extended-spectrum beta-lactamase Toho-1: insights into the molecular mechanism for catalytic reaction and substrate specificity expansion Biochemistry 2003, 42, 10634-10643
-
(2003)
Biochemistry
, vol.42
, pp. 10634-10643
-
-
Ibuka, A.S.1
Ishii, Y.2
Galleni, M.3
Ishiguro, M.4
Yamaguchi, K.5
Frere, J.M.6
Matsuzawa, H.7
Sakai, H.8
-
36
-
-
77649270363
-
Neutron diffraction studies of a class A beta-lactamase Toho-1 E166A/R274N/R276N triple mutant
-
Tomanicek, S. J.; Blakeley, M. P.; Cooper, J.; Chen, Y.; Afonine, P. V.; Coates, L. Neutron diffraction studies of a class A beta-lactamase Toho-1 E166A/R274N/R276N triple mutant J. Mol. Biol. 2010, 396, 1070-1080
-
(2010)
J. Mol. Biol.
, vol.396
, pp. 1070-1080
-
-
Tomanicek, S.J.1
Blakeley, M.P.2
Cooper, J.3
Chen, Y.4
Afonine, P.V.5
Coates, L.6
-
37
-
-
2242480185
-
Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin
-
Shimamura, T.; Ibuka, A.; Fushinobu, S.; Wakagi, T.; Ishiguro, M.; Ishii, Y.; Matsuzawa, H. Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin J. Biol. Chem. 2002, 277, 46601-46608
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 46601-46608
-
-
Shimamura, T.1
Ibuka, A.2
Fushinobu, S.3
Wakagi, T.4
Ishiguro, M.5
Ishii, Y.6
Matsuzawa, H.7
-
38
-
-
0037094114
-
An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation
-
Minasov, G.; Wang, X.; Shoichet, B. K. An ultrahigh resolution structure of TEM-1 beta-lactamase suggests a role for Glu166 as the general base in acylation J. Am. Chem. Soc. 2002, 124, 5333-5340
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 5333-5340
-
-
Minasov, G.1
Wang, X.2
Shoichet, B.K.3
-
39
-
-
78650656824
-
Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors
-
Ke, W.; Sampson, J. M.; Ori, C.; Prati, F.; Drawz, S. M.; Bethel, C. R.; Bonomo, R. A.; van den Akker, F. Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors Antimicrob. Agents Chemother. 2011, 55, 174-183
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 174-183
-
-
Ke, W.1
Sampson, J.M.2
Ori, C.3
Prati, F.4
Drawz, S.M.5
Bethel, C.R.6
Bonomo, R.A.7
Van Den Akker, F.8
-
40
-
-
0026667480
-
Antiallergic and cytoprotective activity of new N -phenylbenzamido acid derivatives
-
Makovec, F.; Peris, W.; Revel, L.; Giovanetti, R.; Redaelli, D.; Rovati, L. C. Antiallergic and cytoprotective activity of new N -phenylbenzamido acid derivatives J. Med. Chem. 1992, 35, 3633-3640
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3633-3640
-
-
Makovec, F.1
Peris, W.2
Revel, L.3
Giovanetti, R.4
Redaelli, D.5
Rovati, L.C.6
-
41
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski, Z.; Minor, W. Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 1997, 276, 307-326
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
42
-
-
0028103275
-
Collaborative Computational Project, N. The CCP4 suite: Programs for protein crystallography
-
Collaborative Computational Project, N. The CCP4 suite: programs for protein crystallography. Acta Crystallogr., Sect. D: Biol. Crystallogr. 1994, 50, 760-763.
-
(1994)
Acta Crystallogr., Sect. D: Biol. Crystallogr.
, vol.50
, pp. 760-763
-
-
-
43
-
-
13244281317
-
Coot: Model-building tools for molecular graphics
-
Emsley, P.; Cowtan, K. Coot: model-building tools for molecular graphics Acta Crystallogr., Sect. D: Biol. Crystallogr. 2004, 60, 2126-2132
-
(2004)
Acta Crystallogr., Sect. D: Biol. Crystallogr.
, vol.60
, pp. 2126-2132
-
-
Emsley, P.1
Cowtan, K.2
|