microRNAs as tumor inhibitors, oncogenes, biomarkers for drug efficacy and outcome predictors in lung cancer (review)

Molecular Medicine Reports

Volumn 5, Issue 4, 2012, Pages 890-894

  Jiang, Yan Wen ^a   Chen, Liang An ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Biomarker; Inhibitors; Lung cancer; Mirans; Oncogenes

Indexed keywords

BIOLOGICAL MARKER; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; MICRORNA; MICRORNA 218; MICRORNA 415; MICRORNA LET 7; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATINUM; PROTEIN P27; STEM CELL FACTOR RECEPTOR; SUNITINIB; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VANDETANIB;

CANCER SURVIVAL; DRUG EFFICACY; GENE CONTROL; GENOME; HUMAN; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MOLECULAR DIAGNOSIS; NONHUMAN; ONCOGENE; OUTCOME ASSESSMENT; PROGNOSIS; REVIEW; RNA PROCESSING; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; BIOLOGICAL MARKERS; CARCINOMA, NON-SMALL-CELL LUNG; HUMANS; LUNG NEOPLASMS; MICRORNAS; ONCOGENES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84863258874     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.776     Document Type: Review

References (46)

1. Ramalingam S, Pawlish K, Gadgeel S, Demers R and Kalemkerian GP: Lung cancer in young patients: analysis of a Surveillance, Epidemiology, and End Results database. J Clin Oncol 16: 651-657, 1998. (Pubitemid 28135612)
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 59: 225-249, 2009.
3. Miller YE: Pathogenesis of lung cancer: 100 year report. Am J Respir Cell Mol Biol 33: 216-223, 2005.
4. Esquela-Kerscher A and Slack FJ: Oncomirs: micro-RNAs with a role in cancer. Nat Rev Cancer 6: 259-269, 2006.
5. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
6. Calin GA, Sevignani C, Dumitru CD, et al: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101: 2999-3004, 2004. (Pubitemid 38327724)
7. Weiss GJ, Bemis LT, Nakajima E, Sugita M, Birks DK, Robinson WA, Varella-Garcia M, Bunn PA Jr, Haney J, Helfrich BA, Kato H, Hirsch FR and Franklin WA: EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Ann Oncol 19: 1053-1059, 2008. (Pubitemid 351796329)
8. He L, He X, Lim LP, et al: A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134, 2005.
9. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D and Slack FJ: RAS is regulated by the let-7 microRNA family. Cell 120: 635-647, 2005. (Pubitemid 40343076)
10. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR and Golub TR: MicroRNA expression profiles classify human cancers. Nature 435: 834-838, 2005. (Pubitemid 40839735)
11. Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866, 2006. (Pubitemid 44629897)
12. Eder M and Scherr M: MicroRNA and lung cancer. N Engl J Med 352: 2446-2448, 2005. (Pubitemid 40958446)
13. Gregory RI and Shiekhattar R: MicroRNA biogenesis and cancer. Cancer Res 65: 3509-3512, 2005. (Pubitemid 40616320)
14. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A and Croce CM: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103: 2257-2261, 2006. (Pubitemid 43271657)
15. Hammond SM: MicroRNAs as oncogenes. Curr Opin Genet Dev 16: 4-9, 2006.
16. Chen X, Ba Y and Ligia M: Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18: 997-1006, 2008.
17. Mitchell PS, Parkin RK, Kroh EM, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105: 10513-10518, 2008.
18. Winter J, Jung S, Keller S, Gregory RI and Diederichs S: Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11: 228-234, 2009.
19. Kumar MS, Lu J, Mercer KL, Golub TR and Jacks T: Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39: 673-677, 2007. (Pubitemid 46676103)
20. Melo SA, Ropero S, Moutinho C, et al: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 41: 365-370, 2009.
21. Hill DA, Ivanovich J, Priest JR, et al: DICER1 mutations in familial pleuropulmonary blastoma. Science 325: 965, 2009.
22. Melo SA, Moutinho C, Ropero S, et al: A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18: 303-315, 2010.
23. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D and Slack FJ: The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67: 7713-7722, 2007.
24. Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA and Jacks T: Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci USA 105: 3903-3908, 2008. (Pubitemid 351723497)
25. Esquela-Kerscher A, Trang P, Wiggins JF, Patrawala L, Cheng A, Ford L, Weidhaas JB, Brown D, Bader AG and Slack FJ: The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 7: 759-764, 2008. (Pubitemid 351520040)
26. Davidson MR, Larsen JE, Yang IA, et al: MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One 5: e12560, 2010.
27. Wang R, Wang ZX, Yang JS, Pan X, De W and Chen LB: MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene 30: 2644-2658, 2011.
28. Liu X, Sempere LF, Ouyang H, et al: MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. Clin Invest 120: 1298-1309, 2010.
29. Wu X and Xiao H: miRNAs modulate the drug response of tumor cells. Sci China C Life Sci 9: 797-801, 2009.
30. Ranade AR, Cherba D, Shridhar S, et al: MicroRNA 92a-2*: a biomarker predictive for chemoresistance and prognostic for survival in small cell lung cancer patients. J Thorac Oncol 5: 1273-1278, 2010.
31. Sarkar FH, Li Y, Wang Z, Kong D and Ali S: Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Updat 13: 57-66, 2010.
32. Xie L, Chen X, Wang L, et al: Cell-free miRNAs may indicate diagnosis and docetaxel sensitivity of tumor cells in malignant effusions. BMC Cancer 11: 256, 2011.
33. Zhang JG, Wang JJ, Zhao F, Liu Q, Jiang K and Yang GH: MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta 411: 11-12, 2010.
34. Weiss G, Nelson K, Edwards D, Boisvert S and Sima C: MicroRNA biomarkers associated with vandetanib, sunitinib, and/or erlotinib resistance. AACR/IASLC 2010.
35. Nelson K, Sima C, Edwards D and Weiss G: MicroRNA biomarkers associated with sunitinib resistance in non-small cell lung cancer. AACR 2010, abstract 3048.
36. Garofalo M, Di LG and Romano G, et al: miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation. Cancer Cell 16: 498-509, 2009.
37. Ceppi P, Mudduluru G and Kumarswamy R, et al: Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res 8: 1207-1216, 2010.
38. Zhu W, Zhu D, Lu S, et al: miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2. Med Oncol: Jan, 2011 [E-pub ahead of print].
39. Dacic S, Kelly L and Shuai Y: miRNA expression profiling of lung adenocarcinomas: correlation with mutational status. Mod Pathol 23: 1577-1582, 2010.
40. Seike M, Goto A, Okano T, et al: MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci USA 106: 12085-12090, 2009.
41. Webster RJ, Giles KM, Price KJ, Zhang PM, Mattick JS and Leedman PJ: Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem 284: 5731-5741, 2009.
42. Cho WC, Chow AS and Au JS: Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur J Cancer 45: 2197-2206, 2009.
43. Saito M, Schetter AJ, Mollerup S, et al: The association of microRNA expression with prognosis and progression in early stage, non small cell lung adenocarcinoma: a retrospective analysis of three cohorts. Clin Cancer Res 17: 1875-1882, 2011.
44. Boeri M, Verri C and Conte D: MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proc Natl Acad Sci USA 108: 3713-3718, 2011.
45. Roybal JD, Zang Y, Ahn YH, et al: miR-200 inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1. Mol Cancer Res 9: 25-35, 2011.
46. Voortman J, Goto A, Mendiboure J, et al: MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. Cancer Res 70: 8288-8298, 2010.