Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily

Journal of Steroid Biochemistry and Molecular Biology

Volumn 129, Issue 3-5, 2012, Pages 139-144

  Jin, Yi ^a   Duan, Ling ^a   Chen, Mo ^a   Penning, Trevor M ^a   Kloosterboer, Helenius J ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NV ORGANON   (Netherlands)

Author keywords

Ketosteroid reduction; Oral contraceptive; Progestin

Indexed keywords

3ALPHA HYDROXYNORETHYNODREL; 3BETA HYDROXYNORETHYNODREL; ALDEHYDE REDUCTASE; ISOENZYME; KETOSTEROID REDUCTASE; METHYL GROUP; NORETHISTERONE; NORETYNODREL; PROTEIN AKR1C1; PROTEIN AKR1C2; PROTEIN AKR1C4; TIBOLONE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME KINETICS; ENZYME MECHANISM; ISOMER; PROTEIN FAMILY; STEREOCHEMISTRY; STEROID METABOLISM;

20-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; CONTRACEPTIVES, ORAL, SYNTHETIC; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; HYDROXYSTEROID DEHYDROGENASES; HYDROXYSTEROIDS; KINETICS; MODELS, MOLECULAR; NORETHYNODREL; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROTEIN BINDING;

EID: 84863234156     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.12.002     Document Type: Article

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