Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2301-2310

  Hwang, Jong Yeon ^a   Attia, Ramy R ^b   Zhu, Fangyi ^b   Yang, Lei ^b   Lemoff, Andrew ^b   Jeffries, Cynthia ^b   Connelly, Michele C ^b   Guy, R Kiplin ^b  

^a Institute Pasteur Korea   (South Korea)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO 3 NITROBENZAMIDE; 4 CHLORO 3 NITROBENZOTHIOAMIDE; 4 METHYL 2 [4 (METHYLSULFONYL) 3 NITROPHENYL]OXAZOLE 5 CARBOXYLIC ACID; BENZOIC ACID DERIVATIVE; ESTER; ETHYL 2 (4 CHLORO 3 NITROPHENYL) 4 METHYLTHIAZOLE 5 CARBOXYLATE; ETHYL 4 METHYL 2 [4 (METHYLSULFONYL) 3 NITROPHENYL] THIAZOLE 5 CARBOXYLATE; ETHYL 4 METHYL 2 [4 (METHYLTHIO) 3 NITROPHENYL]THIAZOLE 5 CARBOXYLATE; HORMONE INHIBITOR; THYROID HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SCREENING; DRUG SYNTHESIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PROTEIN INTERACTION; REPORTER GENE;

GENES, REPORTER; HEP G2 CELLS; HUMANS; MATRIX METALLOPROTEINASE 11; MODELS, MOLECULAR; NITRO COMPOUNDS; NUCLEAR RECEPTOR COACTIVATORS; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); RECEPTORS, THYROID HORMONE; RESPONSE ELEMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; THIAZOLES; TRANSCRIPTION, GENETIC;

EID: 84863230611     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201546m     Document Type: Article

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