A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor β with a peptide of steroid receptor coactivator 2

Journal of Biomolecular Screening

Volumn 16, Issue 6, 2011, Pages 618-627

  Johnson, Ronald L ^a   Hwang, Jong Yeon ^b   Arnold, Leggy A ^b,c   Huang, Ruili ^a   Wichterman, Jennifer ^a   Augustinaite, Indre ^b   Austin, Christopher P ^a   Inglese, James ^a   Guy, R Kiplin ^b   Huang, Wenwei ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

coactivator; HTS; protein protein interaction; small molecule; thyroid receptor

Indexed keywords

FLUORESCEIN; MLS 000336487 01; MLS 000389544 01; MLS 000517219 01; MLS 000517530 01; MLS 001003284 01; MLS 001003365 01; MLS 001010708 01; MLS 001017631 01; NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN INHIBITOR; THYROID HORMONE RECEPTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; FLUORESCENCE POLARIZATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MAMMAL CELL; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION;

CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NUCLEAR RECEPTOR COACTIVATOR 2; PEPTIDES; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; THYROID HORMONE RECEPTORS BETA;

MAMMALIA;

EID: 79960549182     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111402199     Document Type: Article

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