Membrane interactions of designed cationic antimicrobial peptides: The two thresholds

Biopolymers

Volumn 89, Issue 5, 2008, Pages 360-371

  Glukhov, Evgenia ^a,b   Burrows, Lori L ^c   Deber, Charles M ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Antimicrobial peptides; Hydrophobicity threshold; Peptide membrane interactions

Indexed keywords

AMINES; PEPTIDES; PROTEINS;

ANTIMICROBIAL PEPTIDES; CATIONIC ANTIMICROBIAL PEPTIDES; HYDROPHOBICITY THRESHOLD; PEPTIDE-MEMBRANE INTERACTIONS;

DRUG INTERACTIONS;

AMPHOLYTE; CATION; CECROPIN; CECROPIN P1; LEUCINE; MAGAININ; MAGAININ 2 AMIDE; PEPTIDE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; SPGS 34; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DIMERIZATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; FLUORESCENCE SPECTROSCOPY; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIPID MEMBRANE; MAMMAL; MEMBRANE DAMAGE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR INTERACTION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN MOTIF; PSEUDOMONAS AERUGINOSA; CELL MEMBRANE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; SYNTHESIS;

BACTERIA (MICROORGANISMS); MAMMALIA; PSEUDOMONAS AERUGINOSA;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ERYTHROCYTES; HEMOLYSIS; HUMANS; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PSEUDOMONAS AERUGINOSA;

EID: 47749118037     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20917     Document Type: Article

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