Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics

Journal of Controlled Release

Volumn 142, Issue 1, 2010, Pages 22-30

  Buyukozturk, Fulden ^a   Benneyan, James C ^a   Carrier, Rebecca L ^a  

^a Northeastern University   (United States)

Author keywords

Effect of formulation parameters; Experimental design; Oil in water emulsions; SEDDS; Self emulsifying drug delivery systems

Indexed keywords

DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG RELEASE KINETICS; DRUG-RELEASE RATE; EMULSION PROPERTIES; EMULSION SYSTEMS; EXPERIMENTAL DESIGN; FORMULATION DESIGN; LONG CHAINS; MEDIUM CHAIN TRIGLYCERIDES; OIL PHASE; OIL RATIO; OIL-IN-WATER EMULSIONS; PERMEABILITY ENHANCEMENT; PROPYLENE GLYCOLS; SELF-EMULSIFYING DRUG DELIVERY SYSTEM; SOYBEAN OIL; SURFACTANT CONCENTRATIONS; TIGHT JUNCTIONS; TOXIC EFFECT; TWEEN 80; WEIGHT RATIOS;

BIOCHEMISTRY; CAPILLARITY; DESIGN; DRUG DELIVERY; EMULSIONS; GLYCOLS; LEAKAGE (FLUID); PROPYLENE; RATE CONSTANTS; STATISTICS; SURFACE ACTIVE AGENTS;

EMULSIFICATION;

CREMOPHOR; LABRASOL; MEDIUM CHAIN TRIACYLGLYCEROL; NAPROXEN; NEOBEE M5; OCTANOIC ACID DERIVATIVE; OCTANOIN; POLYSORBATE 80; PROPYLENE GLYCOL DICAPRATE; PROPYLENE GLYCOL DICAPRYLATE; SOYBEAN OIL; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; DRUG TRANSPORT; EMULSION; HUMAN; HUMAN CELL; HYDROPHILICITY; INTESTINE MUCOSA PERMEABILITY; LIPOPHILICITY; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SELF EMULSIFYING DRUG DELIVERY SYSTEM; SURFACE CHARGE; TIGHT JUNCTION;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; EMULSIONS; HUMANS; INTESTINES; PHARMACEUTICAL PREPARATIONS; SURFACE-ACTIVE AGENTS;

EID: 76749131979     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.10.005     Document Type: Article

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