Identification of cancer antigens in breast cancer by the SEREX expression cloning method

Breast Cancer

Volumn 6, Issue 4, 1999, Pages 305-311

  Obata, Yuichi ^a   Takahashi, Toshitada ^a   Tamaki, Hiromi ^a   Tominaga, Suketami ^a   Murai, Hiroshi ^a   Iwase, Takushi ^a   Iwata, Hiroji ^a   Mizutani, Mitsuhiro ^a   Chen, Yao Tseng ^b   Old, Lloyd J ^c   Miura, Shigeto ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b Department of Obstetrics Gynecology   (United States)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

Breast cancer; Cancer antigen; Cancer vaccine; SEREX

Indexed keywords

EID: 84863229236     PISSN: 13406868     EISSN: 18804233     Source Type: Journal    
DOI: 10.1007/BF02966445     Document Type: Conference Paper

References (35)

1. van der Bruggen P, Traversari C, Chomez P, et al: A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643-1647, 1991. (Pubitemid 21917508)
2. Van den Eynde BJ, van der Bruggen P: T cell defined tumor antigens. Curr Opin Immunol 9:684-693, 1997. (Pubitemid 27485298)
3. Kawakami Y, Eliyahu S, Delgado CH, et al: Cloning of the gene for a shared human melanoma antigen recognized by autologous T cell infiltrating into tumor. Proc Natl Acad Sci USA 91:3515-3519, 1994. (Pubitemid 24139460)
4. Kawakami Y, Rosenberg SA: Human tumor antigens recognized by T cells. Immunol Res 16:313-339, 1997. (Pubitemid 28026418)
5. Cox AL, Skipper J, Chen Y, et al: Identification of a peptide recognized by five melanoma specific human cytotoxic T cell lines. Science 264:716-719, 1994. (Pubitemid 24185883)
6. Shichijo S, Nakao M, Imai Y, et al: A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J Exp Med 187:277-288, 1998. (Pubitemid 28080057)
7. INK4a-insensitive CDK4 mutant target by cytolytic T lymphocytes in human melanoma. Science 269:1281-1284, 1995.
8. Robbins PF, El-Gamil M, Li YF, et al: A mutated β-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J Exp Med 183:1185-1192, 1996.
9. Rosenberg SA, Yang JC, Schwartzentruber DJ, et al: Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat Med 4:321-327, 1998. (Pubitemid 28144091)
10. Marchand M, van Baren N, Weynants P, et al: Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1. Int J Cancer 80:219-230, 1999. (Pubitemid 29001725)
11. Babbitt BP, Allen PM, Matsueda G, et al: Binding of immunogenic peptides to la histocompatibility molecules. Nature 317:359-361, 1985. (Pubitemid 15232524)
12. Townsend ARM, Rothbard J, Gotch FM, et al: The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44:959-968, 1986. (Pubitemid 16045342)
13. Davis MM, Bjorkman PJ: T-cell antigen receptor genes and T-cell recognition. Nature 334:395-402, 1988.
14. Rammensee HG: Chemistry of peptides associated with MHC class I and class II molecules. Curr Opin Immunol 7:85-96, 1995.
15. Zinkernagel RM, Doherty PC: Restriction of in vivo T-cell mediated cytotoxicity in lymphocytic choriomengitis within a syngeneic or semiallogeneic system. Nature 284:701-702, 1974.
16. Sahin U, Türeci Ö, Schmitt H, et al: Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 92:11810-11813, 1995. (Pubitemid 26014201)
17. Old LJ: Cancer immunology; The search for specificity; G. H. A. Lowes Memorial Lecture. Cancer Res 41:361-375, 1981. (Pubitemid 11179364)
18. Chen YT, Scanlan M, Sahin U, et al: A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci USA 94:1914-1918, 1997. (Pubitemid 27113936)
19. Jager E, Chen YT, Drijfout JW, et al: Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1; Definition of HLA-A2-binding peptide epitopes. J Exp Med 187:265-270, 1998. (Pubitemid 28060443)
20. Türeci Ö, Sahin U, Schobert I, et al: The SSX2 gene, which is involved in the T (X, 18) translocation of synovial sarcomas, codes the human tumor antigen HOM-Mel-40. Cancer Res 56:4766-4772, 1996. (Pubitemid 26338082)
21. Türeci Ö, Schmitt H, Fadle N, et al: Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease. J Biol Chem 272:6416-6422, 1997. (Pubitemid 27118120)
22. Türeci Ö, Dahin U, Zwick C, et al: Identification of a meiosis-specific protein as a new member of the class of cancer/testis antigens. Proc Natl Acad Sci USA 95:5211-5216, 1998. (Pubitemid 28208577)
23. Chen YT, Güre AO, Tsang S, et al: Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc Natl Acad Sci USA 95:6919-6923, 1998. (Pubitemid 28278082)
24. Scanlan MJ, Chen YT, Williamson B, et al: Characterization of human colon cancer antigens recognized by autologous antibodies. Int J Cancer 76:652-658, 1998. (Pubitemid 28243936)
25. Stockert E, Jäger E, Chen YT, et al: A survey of the humoral immune response of cancer patients to a panel of human tumor antigens. J Exp Med 187:1349-1354, 1998. (Pubitemid 28189124)
26. Giire AO, Altorki NK, Stockert E, et al: Human lung cancer antigens recognized by autologous antibodies; Definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21. Cancer Res 58:1034-1041, 1998. (Pubitemid 28182475)
27. Schlichtholz B, Legros Y, Gillet D, et al: The immune response to p53 in breast cancer patients is directed against immuno-dominant epitopes unrelated to the mutational hot spot. Cancer Res 52:6380-6384, 1992.
28. Brass N, Heckel D, Sahin U, et al: Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma. Hum Mol Genet 6:33-39, 1997. (Pubitemid 27033962)
29. Ling M, Wen YJ, Lim SH: Prevalence of antibodies against proteins derived from chronic myeloid leukemia. Blood 92:4764-4770, 1998. (Pubitemid 29005879)
30. Zhang JY, Chan EKL, Peng XX, et al: A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. J Exp Med 189:1101-1110, 1999. (Pubitemid 29169827)
31. Brass N, Racz A, Bauer C, et al: Role of amplified genes in the production of autoantibodies. Blood 93:2158-2166, 1999. (Pubitemid 29153615)
32. Sahin U, Türeci Ö, Pfreundschuh M: Serological identification of human tumor antigens. Curr Opin Immunol 9:709-716, 1997. (Pubitemid 27485301)
33. Türeci Ö, Sahin U, Pfreundschuh M: Serological analysis of human tumor antigens; Molecular definition and implications. Mol Med Today 3:342-349, 1997. (Pubitemid 28119269)
34. Chen YT, Scanlan MJ, Obata Y, et al: Identification of human tumor antigens by serological expression cloning (SEREX). In: Rosenberg SA ed, Biologic Therapy of Cancer; Principles and Practice, J. B. Lippincott Company, Philadelphia. In press.
35. Crew AJ, Clark J, Fisher C, et al: Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J 14:2333-2340, 1994.