The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40

Cancer Research

Volumn 56, Issue 20, 1996, Pages 4766-4772

  Türeci, Özlem ^a   Sahin, Ugur ^a   Schobert, Ingrid ^a   Koslowski, Michael ^a   Schmitt, Holger ^a   Schild, Hans Jörg ^b   Stenner, Frank ^a   Seitz, Gerhardt ^c   Rammensee, Hans Georg ^b   Pfreundschuh, Michael ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c KLINIKUM BAMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR ANTIGEN;

ARTICLE; CANCER IMMUNOTHERAPY; CHROMOSOME TRANSLOCATION 18; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOGENICITY; MAJOR CLINICAL STUDY; MELANOMA; PRIORITY JOURNAL; SYNOVIAL SARCOMA; X CHROMOSOME;

ANTIGENS, NEOPLASM; CHROMOSOMES, HUMAN, PAIR 18; GENE EXPRESSION; HUMANS; NEOPLASMS; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; SARCOMA, SYNOVIAL; TRANSLOCATION, GENETIC; X CHROMOSOME;

EID: 1842398548     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Yanuck, M., Carbone, D. P., Pendleton, C. D., Tsukui, T , Winter, S F., Minna, J D., and Berzofsky, J. A. A mutant p53 tumor suppressor protein is a target for peptide-induced CD8+ cytotoxic T-cells. Cancer Res., 53: 3257-3261, 1993
2. Disis, M. L., Calenoff, E , McLaughlin, G , Murphy, A. E., Cehn, W., Groner, B., Jeschke, B., Lydon, N., McGlynn, E , Livingston, R. B., Moe, R., and Cheever, M. A. Existent T-cell and antibody immunity to HER2/neu protem in patients with breast cancer. Cancer Res., 54: 16-20, 1994.
3. Peace, D. J., Smith, J W., Disis, M. L., Chen, W., and Cheever, M. A. Induction of T cells specific for the mutated segment of oncogenic P21ras protein by immunization in vivo with the oncogenic protein. J. Immunother., 14: 110-114, 1993.
4. Crawford, L V., Pim, D. C., and Bulbrook, R D. Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer. Int. J. Cancer, 30: 403-408, 1992.
5. Disis, M L , Smith, J. W., Murphy, A. E., Chen, W., and Cheever, M A. In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/ neu protooncogene protein. Cancer Res., 54 1071-1076, 1994.
6. Van der Bruggen, P., Traversari, C , Chomez, P., Lurquin, C., De Plaen, E., Van Den Eynde, B., Knuth, A , and Boon, T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma Science (Washington DC), 254: 1643-1647, 1991.
7. Van den Eynde, B., Peeters, O., De Backer, O., Gaugler, B., Lucas, S., and Boon, T. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma J. Exp Med, 182: 689-698, 1995
8. Boel, P., Wildmann, C , Sensi, M. L., Brasseur, R., Renauld, J. C., Coulie, P., Boon, T., and van der Bruggen, P. BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes Immunity, 2: 167-175, 1995.
9. Gaugler, B , Van den Eynde, B., van der Bruggen, P. Romero, R., Gafario, J. J., De Plaen, E., Lethe, B., Brasseur, G., and Boon, T. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes J. Exp. Med , 179: 921-930, 1994.
10. Kawakami, Y., Eliyahu, S , Delgado, S. H., Robbins, P. F., Rivoltini, L., Topalian, S L , Miki, T., and Rosenberg, S. A Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad Sci. USA, 91: 3515-3519, 1994
11. Coulie, P G., Brichard, V., Van Pel, A., Wolfel, T , Schneider, J , Traversat, C., De Plaen, E., Lurquin, C., Ranauld, C. J., and Boon, T. A new gene coding for a differentiation antigen recognized by autologous cytolytic T-lymphocytes on HLA-A2 melanomas. J. Exp Med., 180: 36-42, 1994.
12. Brichard, V., Van Pel, A., Wölfel, T., Wölfel, C , De Plaen, E., Lethe, B., Coulie, T., and Boon, T The tyrosinase gene codes for an antigen recognized by autologous cytolytic T-lymphocytes on HLA-A2 melanomas. J. Exp Med , 178: 489-495, 1993.
13. Wölfel, T., Hauer, M., Schneider, J., Serrano, M., Wölfel, C., Klebmann-Hieb, E., De Plaen, E., Hankeln, T , and Meyer zum Büschenfelde, K.-H A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (Washington DC), 269: 1281-1284, 1995
14. Sahin, U., Tureci, Ö , Schmitt, H., Cocnlovius, B., Johannes, T , Schmits, R., Stenner, F., Luo, G., Schobert, I , and Pfreundschuh, M Human neoplasms elicit multiple immune responses in the autologous host. Proc. Natl. Acad. Sci. USA, 92: 11810-11813, 1995.
15. Short, J M., Fernandez, J. M., Sorge, J. A., and Huse, W D. λZap: a bacteriophage λ expression vector with in vivo excision properties. Nucleic Acids Res., 16: 7583-7600, 1988.
16. Alting-Mees, M A., Sorge, J. A., and Short, J. M PBluescript II: multifunctional cloning and mapping vectors Methods Enzymol, 216: 483-495, 1992.
17. Altschul, S. F., Gish, W , Miller, W., Myers, E. W , and Lipman, D. J. Basic local alignment tool. J Mol Biol , 215 403-410, 1991
18. Batroch, A., and Bucher, P Prosite recent developments. Nucleic Acids Res., 22: 3583-3589, 1994.
19. Frohman, M. A , Dush, M. K., and Martin, G R. Rapid production of full length cDNAs from rare transcripts: amplification using a single gene specific oligonucleotide primer Proc. Natl Acad. Sci USA, 85: 8998-9002, 1988.
20. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987
21. Maniatis, T., Fritsch, E F , and Sambrook, S. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY. Cold Spring Harbor Laboratory, 1982
22. Bradford, M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1976
23. Kwon, B S., Haq, A. K., Pomerantz, S. H., and Halaban, R. Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus Proc. Natl. Acad Sci. USA. 84: 7473-7477, 1987.
24. Kozak, M. J. The scanning model for translation: an update. Cell Biol , 108: 229-241, 1991.
25. Clark, J , Roques, J. P., Crew, J., Gill, S., Shipley, J , Chand, A , Gusterson, B., and Cooper, C S Identification of novel genes SYT and SSX involved in the t(X,18)(p112,q112) translocation found in human synovial sarcoma Nat. Genet., 7. 502-508, 1994
26. Crew, J , Clark, J , Fisher, C., Gill, S., Grimer, R., Chand, A., Shipley, J., Gusterson, B., and Cooper, C S Fusion of SYT to two genes, SSX1 and X2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J., 14: 2333-2340, 1995
27. Worley, K C., Wiese, B. A , and Smith, R. F. BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequences similarity search results Genome Res , 5: 173-184, 1995.
28. Licht, J D , Ro, M., English, M A., Grossel, M., and Hansen, U Selective repression of transcriptional activators at a distance by the Drosophila Kruppel protein Proc. Natl. Acad. Sci. USA. 90: 11361-11365, 1993.
29. Margolin, J F., Friedman, R., Meyer, W K H., Vising, H , Thiesen, H J., and Rauscher, F J. Kruppel-associated boxes are potent transcriptional repression domains Proc. Natl. Acad Sci. USA., 91: 4509-4513, 1994
30. Bellefroid, E. J , Poncelet, D. A., Lecocq, P J , Relelant, O , and Martial, J. A. The evolutionary conserved Kruppel-associated box domain defines a subfamily of eucaryotic multifingered proteins Proc Natl Acad Sci. USA, 88: 3608-3612, 1991
31. Witzgall, R., O'Leary, E , Leaf, A., Onaldi, D , and Bonventre, J V The Kruppel-associated box A (KRAB-A) domain of zinc finger proteins in transcriptional repression. Proc Natl. Acad. Sci. USA. 91: 4514-4518, 1994.
32. Smith, S , Reeves, B R., Wong, L., and Fisher, C. A. A consistent chromosomal translocation in synovia sarcomas. Cancer Genet. Cytogenet, 26, 179-180, 1987.
33. Shipley, J M , Clark, J , Crew, A. J., Birdsall, S., Rocques, P. J., Gill, S., Chelly, J., Monaco, A. P., Abe, S., Gusterson, B. A., and Cooper C. S. The t(X;18)(p11.2;q11;2) translocation found in human synovial sarcomas involves two distinct loci on the X-chromosome Oncogene., 9: 1447-1453, 1994.
34. Sonobe, H , Manabe, Y., Furihata, M , Iwata, J , Oka, T., Ohtsuki, Y., Mizobuchi, H., Yamamoto, H., Kumano, O , and Abe, S. Establishment and characterization of a new human synovial sarcoma cell line HS-SY-II. Lab. Invest., 67: 498-505, 1992.
35. Turc-Carel, C., Deil-Cin, P , Limon, J., Rao, U , Li, F. P., Corson, J M., Zimmermann, R., Parry, D M., Cowan, J. M , and Sandberg, A. A Involvement of chromosome X in primary cytogenetic change in human neoplasia. non-random translocation in synovial sarcoma. Proc. Natl. Acad. Sci USA, 84: 1981-1985, 1987.
36. Limon, J., Mrozek, K., Mandahl, N., Nedoszytko, B., Verherst, A, Rys, J., Niezabitowski, A., Babinska, M., Nosch, H., Ochalek, T., Kopac, Z, A , Willén, H , Rydholm, A., Heim, S., and Mitelman, F. Cytogenetics in synovial sarcoma: Presentation of ten new cases and review of the literature. Genes Chromosomes & Cancer (Phila), 3, 338-345, 1991.
37. Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev Immunol., 12: 991-1045, 1994.
38. Topalian, S. L., Rivoltini, L., Mancini, M , Markus, N. R., Robbins, P. F., Kawakami, Y., and Rosenberg, S. A. Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene. Proc. Nad. Acad. Sci. USA, 91: 9461-9465, 1994.
39. Vijayasaradhi, S , and Houghton, A- N. Purification of an autoantigenic 75 kDa human melanosomal glycoprotein. Int. J. Cancer, 47: 298-303, 1991.
40. Wang, R-F., Robbins, P. F., Kawakami, Y , Kanga, X-Q , and Rosenberg, S A. Identification of gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes. J. Exp. Med., 181: 799-804, 1995.
41. Kawakami, Y., Eliyahu, S., Delgado, C. H., Robbins, P. F., Sakaguchi, K , Appella, E , Yannelli, J. R , Adema, G. J , Miki, T , Rosenberg, S. A Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Nail. Acad Sci. USA, 91: 6458-6462, 1994.
42. Cut, J, and Bystryn, J-C. Melanoma and vitiligo are associated with antibody responses to similar antigens on pigment cells. Arch Dermatol., 131 314-318, 1995.
43. Nordlund, J. J., Kirkwood, J. M., Forget, B M , Milton, G , Albert, D. M., and Lerner, A. B Vitiligo in patients with metastatic melanoma: a good prognostic sign. J. Am. Acad Dermatol , 9: 689-696, 1983.
44. Hoon, D S , Yuzuki, D., Hayashida, M., and Morton, D. L. Melanoma patients immunized with melanoma cell vaccine induce antibody responses to recombinant MAGE-1 antigen. J. Immunol., 154: 730-737, 1995.