Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor

Journal of Molecular Endocrinology

Volumn 38, Issue 1-2, 2007, Pages 79-90

  Presul, Elisabeth ^a   Schmidt, Stefan ^a,b   Kofler, Reinhard ^a,b   Helmberg, Arno ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b TYROLEAN CANCER RESEARCH INSTITUTE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL LINEAGE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DONOR SITE; EXON; GENE AMPLIFICATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TISSUE DISTRIBUTION;

ALTERNATIVE SPLICING; BASE SEQUENCE; CELL LINE; EXONS; HUMANS; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; SEQUENCE ANALYSIS, DNA;

EID: 33847620168     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.1.02183     Document Type: Article

References (53)

1. Ayoubi TA & Van De Ven WJ 1996 Regulation of gene expression by alternative promoters. FASEB Journal 10 453-460.
2. Beato M, Chalepakis G, Schauer M & Slater EP 1989 DNA regulatory elements for steroid hormones. Journal of Steroid Biochemistry 32 737-747.
3. Breslin MB, Geng CD & Vedeckis WV 2001 Multiple promoters exist in the human CR gene, one of which is activated by glucocorticoids. Molecular Endocrinology 15 1381-1395.
4. Burnstein KL, Bellingham DL, Jewell CM, Powell-Oliver FE & Cidlowski JA 1991 Autoregulation of glucocorticoid receptor gene expression. Steroids 56 52-58.
5. Chen F, Watson CS & Gametchu B 1999 Multiple glucocorticoid receptor transcripts in membrane glucocorticoid receptor-enriched S-49 mouse lymphoma cells. Journal of Cellular Biochemistry 74 418-429.
6. Cowell IG 2002 E4BP4/NFIL3, a PAR-related bZIP factor with many roles. Bioessays 24 1023-1029.
7. Cowell IG, Skinner A & Hurst HC 1992 Transcriptional repression by a novel member of the bZIP family of transcription factors. Molecular and Cellular Biology 12 3070-3077.
8. Dong Y, Poellinger L, Gustafsson JA & Okret S 1988 Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms. Molecular Endocrinology 2 1256-1264.
9. Eisen LP, Elsasser MS & Harmon JM 1988 Positive regulation of the glucocorticoid receptor in human T-cells sensitive to the cytolytic effects of glucocorticoids. Journal of Biological Chemistry 263 12044-12048.
10. Findley HW Jr, Cooper MD, Kim TH, Alvarado C & Ragab AH 1982 Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes. Blood 60 1305-1309.
11. Funk WD & Wright WE 1992 Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor. PNAS 89 9484-9488.
12. Geley S, Hartmann BL, Hala M, Strasser-Wozak EM, Kapelari K & Kofler R 1996 Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression. Cancer Research 56 5033-5038.
13. Geley S, Kramer E, Gieffers C, Gannon J, Peters JM & Hunt T 2001 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. Journal of Cell Biology 153 137-148.
14. Geng CD & Vedeckis WV 2004 Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter. Molecular Endocrinology 18 912-924.
15. Geng CD & Vedeckis WV 2005 c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. Journal of Biological Chemistry 280 43264-43271.
16. Gomi M, Moriwaki K, Katagiri S, Kurata Y & Thompson EB 1990 Glucocorticoid effects on myeloma cells in culture: correlation of growth inhibition with induction of glucocorticoid receptor messenger RNA. Cancer Research 50 1873-1878.
17. Groenen MA, Dijkhof RJ, van der Poel JJ, van Diggelen R & Verstege E 1992 Multiple octamer binding sites in the promoter region of the bovine alpha s2-casein gene. Nucleir Acids Research 20 4311-4318.
18. Hala M, Hartmann BL, Bock G, Geley S & Kofler R 1996 Glucocorticoid-receptor-gene defects and resistance to glucocorticoid-induced apoptosis in human leukemic cell lines. Nucleic Acids Research 68 663-668.
19. Helmberg A, Auphan N, Caelles C & Karin M 1995 Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO Journal 14 452-460.
20. Kalinyak JE, Dorin RI, Hoffman AR & Perlman AJ 1987 Tissue-specific regulation of glucocorticoid receptor mRNA by dexamethasone. Journal of Biological Chemistry 262 10441-10444.
21. Ko LJ & Engel JD 1993 DNA-binding specificities of the GATA transcription factor family. Molecular and Cellular Biolagy 13 4011-4022.
22. Kofler R, Schmidt S, Kofler A & Ausserlechner MJ 2003 Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia. Journal of Endocrinology 178 19-27.
23. Kos M, Denger S, Reid G & Gannon F 2002 Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha. Journal of Biological Chemistry 277 37131-37138.
24. Levy DE, Kessler DS, Pine R, Reich N & Darnell JE Jr 1988 Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes and Development 2 383-393.
25. Lin R, Genin P, Mamane Y & Hiscott J 2000 Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Molecular and Cellular Biology 20 6342-6353.
26. Mangalam HJ, Albert VR, Ingraham HA, Kapiloff M, Wilson L, Nelson C, Elsholtz H & Rosenfeld MG 1989 A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. Genes and Development 3 946-958.
27. McCormick JA, Lyons V, Jacobson MD, Noble J, Diorio J, Nyirenda M, Weaver S, Ester W, Yau JL, Meaney MJ et al. 2000 5′-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Molecular Endocrinology 14 506-517.
28. Medh RD, Webb MS, Miller AL, Johnson BH, Fofanov Y, Li T, Wood TG, Luxon BA & Thompson EB 2003 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics 81 543-555.
29. Muller PY, Janovjak H, Miserez AR & Dobbie Z 2002 Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32 1372-1379.
30. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F & Riccardi C 1991 A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods 139 271-279.
31. Norman MR & Thompson EB 1977 Characterization of a glucocorticoid-sensitive human lymphoid cell line. Cancer Research 37 3785-3791.
32. Nunez BS & Vedeckis WV 2002 Characterization of promoter 1B in the human glucocorticoid receptor gene. Molecular and Cellular Endocrinology 189 191-199.
33. Obexer P, Certa U, Kofler R & Helmberg A 2001 Expression profiling of glucocorticoid-treated T-ALL cell lines: rapid repression of multiple genes involved in RNA, protein- and nucleotide synthesis. Oncogene 20 4324-4336.
34. Parson W, Kirchelmer R, Muhlmann R, Renner K, Kofler A, Schmidt S & Kotler R 2005 Cancer cell line identification by short tandem repeat profiling: power and limitations. FASEB Journal 19 434-436.
35. Pedersen KB & Vedeckis WV 2003 Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 42 10978-10990.
36. Pedersen KB, Geng CD & Vedeckis WV 2004 Three mechanisms are involved in glucocorticoid receptor autoregulation in a human T-lymphoblast cell line. Biochemistry 43 10851-10858.
37. Reese MG, Eeckman FH, Kulp D & Haussler D 1997 Improved splice site detection in Genie. Journal of Computational Biology 4 311-323.
38. Riml S, Schmidt S, Ausserlechner MJ, Geley S & Kofler R 2004 Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells. Cell Death and Differentiation 11 S65-S72.
39. Sapolsky RM, Romero LM & Munck AU 2000 How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews 21 55-89.
40. Schimmer BP & Parker KL 2006 Adrenocortical steroids. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 11 edn, pp 1593-1610. Eds L Brunton, J Lazo & K Parker. New York: McGraw-Hill.
41. Schmidt S, Rainer J, Riml S, Ploner C, Jesacher S, Achmuller C, Presul E, Skvortsov S, Crazzolara R, Fiegl M et al. 2006 Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemia. Blood 107 2061-2069.
42. Schmidt S, Irving JA, Minto L, Matheson E, Nicholson L, Ploner A, Parson IN, Kofler A, Amort M, Erdel M et al 2006 Glucocorticoid resistance in 2 key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor. FASEB Journal In press.
43. Strahle U, Schmidt A, Kelsey G, Stewart AF, Cole TJ, Schmid W & Schutz G 1992 At least three promoters direct expression of the mouse glucocorticoid receptor gene. PNAS 89 6731-6735.
44. Strasser-Wozak EM, Hattmannstorfer R, Hala M, Hartmann BL, Fiegl M, Geley S & Kofler R 1995 Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line. Cancer Research 55 348-353.
45. Tissing WJ, Meijerink JP, Brinkhof B, Broekhuis MJ, Menezes RX, den Boer ML & Pieters R 2006 Glucocorticoid-induced glucocorticoid-receptor expression and promoter usage is not linked to glucocorticoid resistance in childhood ALL. Blood 108 1045-1049.
46. Tonko M, Ausserlechner MJ, Bernhard D, Helmberg A & Kofler R 2001 Gene expression profiles of proliferating vs. G1/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis. FASEB Journal 15 693-699.
47. Turner JD & Muller CP 2005 Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: identification, and tissue distribution of multiple new human exon 1. Journal of Molecular Endocrinology 35 283-292.
48. Wallace AD, Wheeler TT & Young DA 1997 Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids. Biochemical and Biophysical Research communications 232 403-406.
49. Yoshida NL, Miyashita T, U M, Yamada M, Reed JC, Sugita Y & Oshida T 2002 Analysis of gene expression patterns during glucocorticoid-induced apoptosis using oligonucleotide arrays. Biochemical and Biophysical Research Communications 293 1254-1261.
50. Yudt MR & Cidlowski JA 2001 Molecular identification and characterization of a and b forms of the glucocorticoid receptor. Molecular Endocrinology 15 1093-1103.
51. Zhang W, Zhang J, Kornuc M, Kwan K, Frank R & Nimer SD 1995 Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. Molecular and Cellular Biology 15 6055-6063.
52. Zhang T, Haws P & Wu Q 2004 Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Genome Research 14 79-89.
53. Zong J, Ashraf J & Thompson EB 1990 The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites. Molecular and Cellular Biology 10 5580-5585.