Polyethylene particles stimulate expression of ITAM-related molecules in peri-implant tissues and when stimulating osteoclastogenesis in vitro

Acta Biomaterialia

Volumn 8, Issue 8, 2012, Pages 3104-3112

  Alias, E ^a,b   Dharmapatni, A S S K ^a   Holding, A C ^a   Atkins, G J ^a,c   Findlay, D M ^a,c   Howie, D W ^a,d   Crotti, T N ^a   Haynes, D R ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^c HANSON INSTITUTE   (Australia)

^d ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Joint replacement; Osteoclast; Osteolysis; Polyethylene; Wear debris

Indexed keywords

AMINO ACIDS; JOINT PROSTHESES; JOINTS (ANATOMY); MOLECULES; POLYETHYLENES; TISSUE;

IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS; IN-VITRO; JOINT REPLACEMENT; OSTEOCLAST; OSTEOCLAST FORMATION; OSTEOLYSIS; POLYETHYLENE PARTICLES; POLYETHYLENE WEAR; WEAR DEBRIS; WEAR PARTICLES;

HISTOLOGY;

FC RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; OSTEOCLAST ASSOCIATED RECEPTOR; POLYETHYLENE; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPLANT; IN VITRO STUDY; INTRACELLULAR SIGNALING; JOINT PROSTHESIS; MALE; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE;

EID: 84863223427     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.04.037     Document Type: Article

References (72)

1. S.E. Graves, D. Davidson, L. Ingerson, P. Ryan, E.C. Griffith, and B.F. McDermott The Australian orthopaedic association national joint replacement registry Med J Aust 180 2004 S31 S34
2. D.W. Howie Tissue response in relation to type of wear particles around failed hip arthroplasties J Arthroplasty 5 1990 337 348
3. D.R. Haynes, T.N. Crotti, A.E. Potter, M. Loric, G.J. Atkins, and D.W. Howie The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis J Bone Joint Surg Br 83 2001 902 911
4. Z. Shen, T.N. Crotti, K.P. McHugh, K. Matsuzaki, E.M. Gravallese, and B.E. Bierbaum The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis Arthritis Res Ther 8 2006 R70
5. R.J. Looney, A. Boyd, S. Totterman, G.S. Seo, J. Tamez-Pena, and D. Campbell Volumetric computerized tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear Arthritis Res 4 2002 59 63
6. K.J. Kim, Y. Kobayashi, and T. Itoh Osteolysis model with continuous infusion of polyethylene particles Clin Orthop Relat Res 1998 46 52
7. M. Takagi, S. Santavirta, H. Ida, M. Ishii, I. Takei, and S. Niissalo High-turnover periprosthetic bone remodeling and immature bone formation around loose cemented total hip joints J Bone Miner Res 16 2001 79 88
8. G.J. Atkins, D.R. Haynes, D.W. Howie, and D.M. Findlay Role of polyethylene particles in peri-prosthetic osteolysis: a review World J Orthop 18 2011 93 101
9. H.H. Kim, H.S. Shin, H.J. Kwak, K.Y. Ahn, J.H. Kim, and H.J. Lee RANKL regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway FASEB J 17 2003 2163 2165
10. H. Takayanagi Inflammatory bone destruction and osteoimmunology J Periodontal Res 40 2005 287 293
11. H. Hirotani, N.A. Tuohy, J.T. Woo, P.H. Stern, and N.A. Clipstone The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cells J Biol Chem 279 2004 13984 13992
12. K. Kim, J.H. Kim, J. Lee, H.M. Jin, S.H. Lee, and D.E. Fisher Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis J Biol Chem 280 2005 35209 35216
13. M. Matsumoto, M. Kogawa, S. Wada, H. Takayanagi, M. Tsujimoto, and S. Katayama Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1 J Biol Chem 279 2004 45969 45979
14. S.M. Sharma, R. Hu, A. Bronisz, N. Meadows, T. Lusby, and B. Fletcher Genetics and genomics of osteoclast differentiation: integrating cell signaling pathways and gene networks Crit Rev Eukaryot Gene Expr 16 2006 253 277
15. Y. Kim, K. Sato, M. Asagiri, I. Morita, K. Soma, and H. Takayanagi Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis J Biol Chem 280 2005 32905 32913
16. T.N. Crotti, M. Flannery, N.C. Walsh, J.D. Fleming, S.R. Goldring, and K.P. McHugh NFATc1 directly induces the human beta3 integrin gene in osteoclast differentiation J Musculoskelet Neuronal Interact 5 2005 335 337
17. T.N. Crotti, M. Flannery, N.C. Walsh, J.D. Fleming, S.R. Goldring, and K.P. McHugh NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation Gene 372 2006 92 102
18. T.N. Crotti, S.M. Sharma, J.D. Fleming, M.R. Flannery, M.C. Ostrowski, and S.R. Goldring PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter J Cell Physiol 215 2008 636 644
19. L.B. Ivashkiv Cross-regulation of signaling by ITAM-associated receptors Nat Immunol 10 2009 340 347
20. S. Ishikawa, N. Arase, T. Suenaga, Y. Saita, M. Noda, and T. Kuriyama Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR) Int Immunol 16 2004 1019 1025
21. E. Merck, C. Gaillard, D.M. Gorman, F. Montero-Julian, I. Durand, and S.M. Zurawski OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells Blood 104 2004 1386 1395
22. E. Merck, C. Gaillard, M. Scuiller, P. Scapini, M.A. Cassatella, and G. Trinchieri Ligation of the FcR gamma chain-associated human osteoclast- associated receptor enhances the proinflammatory responses of human monocytes and neutrophils J Immunol 176 2006 3149 3156
23. M.R. Daws, L.L. Lanier, W.E. Seaman, and J.C. Ryan Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family Eur J Immunol 31 2001 783 791
24. A. Bouchon, C. Hernandez-Munain, M. Cella, and M. Colonna A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells J Exp Med 194 2001 1111 1122
25. M.B. Humphrey, M.R. Daws, S.C. Spusta, E.C. Niemi, J.A. Torchia, and L.L. Lanier TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function J Bone Miner Res 21 2006 237 245
26. M. Cella, C. Buonsanti, C. Strader, T. Kondo, A. Salmaggi, and M. Colonna Impaired differentiation of osteoclasts in TREM-2-deficient individuals J Exp Med 198 2003 645 651
27. J. Paloneva, J. Mandelin, A. Kiialainen, T. Bohling, J. Prudlo, and P. Hakola DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features J Exp Med 198 2003 669 675
28. T. Kaifu, J. Nakahara, M. Inui, K. Mishima, T. Momiyama, and M. Kaji Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice J Clin Invest 111 2003 323 332
29. T. Koga, M. Inui, K. Inoue, S. Kim, A. Suematsu, and E. Kobayashi Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis Nature 428 2004 758 763
30. H. Takayanagi Mechanistic insight into osteoclast differentiation in osteoimmunology J Mol Med 83 2005 170 179
31. B. Nivbrant, K. Karlsson, and J. Karrholm Cytokine levels in synovial fluid from hips with well-functioning or loose prostheses J Bone Joint Surg Br 81 1999 163 166
32. G. Sypniewska, K. Lis, and P.J. Bilinski Bone turnover markers and cytokines in joint fluid: analyses in 10 patients with loose hip prosthesis and 39 with coxarthrosis Acta Orthop Scand 73 2002 518 522
33. S.A. Clarke, R.A. Brooks, J.L. Hobby, J.A. Wimhurst, B.J. Myer, and N. Rushton Correlation of synovial fluid cytokine levels with histological and clinical parameters of primary and revision total hip and total knee replacements Acta Orthop Scand 72 2001 491 498
34. M.K. Andersson, P. Lundberg, A. Ohlin, M.J. Perry, A. Lie, and A. Stark Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients Arthritis Res Ther 9 2007 R18
35. S. Herman, R.B. Muller, G. Kronke, J. Zwerina, K. Redlich, and A.J. Hueber Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis Arthritis Rheum 58 2008 3041 3050
36. A.A. Dharmapatni, M.D. Smith, D.M. Findlay, C.A. Holding, A. Evdokiou, and M.J. Ahern Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium Arthritis Res Ther 11 2009 R13
37. M.C. Kraan, J.J. Haringman, M.J. Ahern, F.C. Breedveld, M.D. Smith, and P.P. Tak Quantification of the cell infiltrate in synovial tissue by digital image analysis Rheumatology (Oxford) 39 2000 43 49
38. P.P. Tak, P.A. van der Lubbe, A. Cauli, M.R. Daha, T.J. Smeets, and P.M. Kluin Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis Arthritis Rheum 38 1995 1457 1465
39. T.N. Crotti, M.D. Smith, H. Weedon, M.J. Ahern, D.M. Findlay, and M. Kraan Receptor activator NF-kappaB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis Ann Rheum Dis 61 2002 1047 1054
40. T.N. Crotti, M.D. Smith, D.M. Findlay, H. Zreiqat, M.J. Ahern, and H. Weedon Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss: expression of receptor activator NFkappaB, RANK ligand and osteoprotegerin Biomaterials 25 2004 565 573
41. M.C. Kraan, J.J. Haringman, W.J. Post, J. Versendaal, F.C. Breedveld, and P.P. Tak Immunohistological analysis of synovial tissue for differential diagnosis in early arthritis Rheumatology (Oxford) 38 1999 1074 1080
42. T.R. Green, J. Fisher, M. Stone, B.M. Wroblewski, and E. Ingham Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro Biomaterials 19 1998 2297 2302
43. T. Matsusaki, K. Kawanabe, K. Ise, T. Nakayama, J. Toguchida, and T. Nakamura Gene expression profile of macrophage-like U937 cells in response to polyethylene particles: a novel cell-particle culture system J Arthroplasty 22 2007 960 965
44. G.J. Atkins, K.J. Welldon, C.A. Holding, D.R. Haynes, D.W. Howie, and D.M. Findlay The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles Biomaterials 30 2009 3672 3681
45. C.A. Holding, D.M. Findlay, R. Stamenkov, S.D. Neale, H. Lucas, and A.S. Dharmapatni The correlation of RANK, RANKL and TNFalpha expression with bone loss volume and polyethylene wear debris around hip implants Biomaterials 27 2006 5212 5219
46. M. Kogawa, D.M. Findlay, P.H. Anderson, R. Ormsby, C. Vincent, and H.A. Morris Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption Endocrinology 151 2010 4613 4625
47. K.F. Orishimo, A.M. Claus, C.J. Sychterz, and C.A. Engh Relationship between polyethylene wear and osteolysis in hips with a second-generation porous-coated cementless cup after seven years of follow-up J Bone Joint Surg Am 85A 2003 1095 1099
48. R.M. Granfar, C.J. Day, M.S. Kim, and N.A. Morrison Optimised real-time quantitative PCR assays for RANKL regulated genes Mol Cell Probes 19 2005 119 126
49. A. Untergasser, H. Nijveen, X. Rao, T. Bisseling, R. Geurts, and J.A. Leunissen Primer3Plus, an enhanced web interface to Primer3 Nucleic Acids Res 35 2007 W71 W74
50. M.E. Franssen, P.L. Zeeuwen, G. Vierwinden, P.C. van de Kerkhof, J. Schalkwijk, and P.E. van Erp Phenotypical and functional differences in germinative subpopulations derived from normal and psoriatic epidermis J Invest Dermatol 124 2005 373 383
51. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408
52. A. Vasudevan, E.F. Dicarlo, T. Wright, D. Chen, M.P. Figgie, and S.R. Goldring Cellular response to prosthetic wear debris differs in patients with and without rheumatoid arthritis Arthritis Rheum 64 2012 1005 1014
53. Herman S, Polzer K, Zwerina J, Redlich K, Scheinecker C, Schett G. Osteoclast-associated-receptor (OSCAR) and its role in rheumatoid arthritis. In: American College of Rheumatology 2007 Annual Scientific Meeting, Boston, MA, 2007. p. 1304.
54. N. Kim, M. Takami, J. Rho, R. Josien, and Y. Choi A novel member of the leukocyte receptor complex regulates osteoclast differentiation J Exp Med 195 2002 201 209
55. C. Goettsch, M. Rauner, K. Sinningen, S. Helas, N. Al-Fakhri, and K. Nemeth The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells Endocrinology 152 2011 0000-0000
56. K. Nemeth, M. Schoppet, N. Al-Fakhri, S. Helas, R. Jessberger, and L.C. Hofbauer The role of osteoclast-associated receptor in osteoimmunology J Immunol 186 2011 13 18
57. C.H. Chen, H.T. Liao, H.A. Chen, T.H. Liang, C.T. Wang, and C.T. Chou Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a new mediator involved in early ankylosing spondylitis J Rheumatol 35 2008 1846 1848
58. C.E. Collins, D.T. La, H.T. Yang, F. Massin, S. Gibot, and G. Faure Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis Ann Rheum Dis 68 2009 1768 1774
59. Y. Murakami, T. Akahoshi, N. Aoki, M. Toyomoto, N. Miyasaka, and H. Kohsaka Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis Arthritis Rheum 60 2009 1615 1623
60. J. Kuai, B. Gregory, A. Hill, D.D. Pittman, J.L. Feldman, and T. Brown TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines Rheumatology (Oxford) 48 2009 1352 1358
61. M.B. Humphrey, L.L. Lanier, and M.C. Nakamura Role of ITAM-containing adapter proteins and their receptors in the immune system and bone Immunol Rev 208 2005 50 65
62. K.H. Park-Min, J.D. Ji, T. Antoniv, A.C. Reid, R.B. Silver, and M.B. Humphrey IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression J Immunol 183 2009 2444 2455
63. J.H. Chang, E.J. Chang, H.H. Kim, and S.K. Kim Enhanced inhibitory effects of a novel CpG motif on osteoclast differentiation via TREM-2 down-regulation Biochem Biophys Res Commun 389 2009 28 33
64. M. Colonna, I. Turnbull, and J. Klesney-Tait The enigmatic function of TREM-2 in osteoclastogenesis Adv Exp Med Biol 602 2007 97 105
65. W. Zou, T. Zhu, C.S. Craft, T.J. Broekelmann, R.P. Mecham, and S.L. Teitelbaum Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts J Cell Sci 123 2010 2955 2963
66. W. Zou, J.L. Reeve, Y. Liu, S.L. Teitelbaum, and F.P. Ross DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk Mol Cell 31 2008 422 431
67. F. Abtahian, N. Bezman, R. Clemens, E. Sebzda, L. Cheng, and S.J. Shattil Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells Mol Cell Biol 26 2006 6936 6949
68. A. Mocsai, C.L. Abram, Z. Jakus, Y. Hu, L.L. Lanier, and C.A. Lowell Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs Nat Immunol 7 2006 1326 1333
69. I. Roato, D. Caldo, L. D'Amico, P. D'Amelio, L. Godio, and S. Patane Osteoclastogenesis in peripheral blood mononuclear cell cultures of periprosthetic osteolysis patients and the phenotype of T cells localized in periprosthetic tissues Biomaterials 31 2010 7519 7525
70. S. Landgraeber, M. von Knoch, F. Loer, J. Brankamp, M. Tsokos, and F. Grabellus Association between apoptotis and CD4(+)/CD8(+) T-lymphocyte ratio in aseptic loosening after total hip replacement Int J Biol Sci 5 2009 182 191
71. Y. Yamanaka, W. Abu-Amer, D. Foglia, J. Otero, J.C. Clohisy, and Y. Abu-Amer NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis J Orthop Res 26 2008 1577 1584
72. X. Hu, J. Chen, L. Wang, and L.B. Ivashkiv Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation J Leukoc Biol 82 2007 237 243