Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 2, 2012, Pages 903-909

  Hu, Yang ^a   Lu, Xiang ^a   Chen, Ke ^a   Yan, Ru ^a   Li, Qing Shan ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

1,3,4 Oxadiazoline; Combrestastatin A4; Molecular docking; Tubulin inhibitors

Indexed keywords

1,3,4 OXADIAZOLINE DERIVATIVE; 2 (2' NAPHTHYL) 5 (2'' BROMOPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (2'' CHLOROPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (2'' FLUOROPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (2'' HYDROXYPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (2'' NAPHTHYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (2'' NITROPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (2'' PYRIDINYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (3'' BROMOPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (3'' FLUOROPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (3'' PYRIDINYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' BENZYLOXYPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' BROMOPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' CHLOROPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' FLUOROPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' METHOXYPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' METHYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' NITROPHENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' PYRIDINYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 (4'' THIENYL) 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; 2 (2' NAPHTHYL) 5 PHENYL 2 ACETYL 2,3 DIHYDRO 1,3,4 OXADIAZOLINE; ANTINEOPLASTIC AGENT; PROTEIN INHIBITOR; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROGEN BONDING; NAPHTHALENES; OXADIAZOLES; OXAZOLES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STILBENES; TUBULIN; TUBULIN MODULATORS;

EID: 84855777422     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.057     Document Type: Article

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