Microbeam radiation therapy alters vascular architecture and tumor oxygenation and is enhanced by a galectin-1 targeted anti-angiogenic peptide

Radiation Research

Volumn 177, Issue 6, 2012, Pages 804-812

  Griffin, Robert J ^a   Koonce, Nathan A ^a   Dings, Ruud P M ^b   Siegel, Eric ^a   Moros, Eduardo G ^a   Bruer Krisch, Elke ^c   Corry, Peter M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGINEX; CD31 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; CANCER RADIOTHERAPY; CONTROLLED STUDY; DENSITY; ENDOTHELIUM CELL; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; MICROBEAM RADIATION THERAPY; MOUSE; NONHUMAN; OXYGENATION; PERICYTE; PRIORITY JOURNAL; RADIATION DOSE; TUMOR GROWTH; TUMOR VOLUME;

ANGIOGENESIS INHIBITORS; ANIMALS; BLOOD VESSELS; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; GALECTIN 1; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MOLECULAR TARGETED THERAPY; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; PEPTIDES; RADIOMETRY; RADIOTHERAPY;

ANIMALIA;

EID: 84863202783     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2784.1     Document Type: Article

References (48)

1. Dilmanian FA, Button TM, Le Duc G, Zhong N, Pena LA, Smith JA, et al. Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. Neuro-Oncology 2002; 4(1):26-38. (Pubitemid 34269464)
2. Dilmanian FA, Morris GM, Zhong N, Bacarian T, Hainfeld JF, Kalef-Ezra J, et al. Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy. Radiat Res 2003; 159(5): 632-41. (Pubitemid 36539242)
3. Dilmanian FA, Qu Y, Liu S, Cool CD, Gilbert J, Hainfeld JF, et al. X-ray microbeams: Tumor therapy and central nervous system research. Nuc Instrum Methods Phys Res 2005; 548(1-2):30-7. (Pubitemid 41084906)
4. Smilowitz HM, Blattmann H, Brauer-Krisch E, Bravin A, Di Michiel M, Gebbers JO, et al. Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosarcomas. J Neuro-Oncology 2006; 78(2):135-43. (Pubitemid 44348441)
5. Slatkin DN, Spanne P, Dilmanian FA, Sandborg M. Microbeam radiation therapy. Med Phys 1992; 19(6):1395-400.
6. Bouchet A, Lemasson B, Le Duc G, Maisin C, Brauer-Krisch E, Siegbahn EA, et al. Preferential effect of synchrotron microbeam radiation therapy on intracerebral 9L gliosarcoma vascular networks. Int J Radiat Oncolo Biolo Phys 2010; 78(5):1503-12.
7. Serduc R, Bouchet A, Brauer-Krisch E, Laissue JA, Spiga J, Sarun S, et al. Synchrotron microbeam radiation therapy for rat brain tumor palliation-influence of the microbeam width at constant valley dose. Phys Med Biol 2009; 54(21):6711-24.
8. Serduc R, Brauer-Krisch E, Bouchet A, Renaud L, Brochard T, Bravin A, et al. First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy. J Synchro Radiat 2009;16(Pt 4):587-90.
9. Serduc R, Brauer-Krisch E, Siegbahn EA, Bouchet A, Pouyatos B, Carron R, et al. High-precision radiosurgical dose delivery by interlaced microbeam arrays of high-flux low-energy synchrotron X-rays. PLoS One 2010; 5(2):e9028.
10. Serduc R, Christen T, Laissue J, Farion R, Bouchet A, Sanden B, et al. Brain tumor vessel response to synchrotron microbeam radiation therapy: a short-term in vivo study. Phys Med Biol 2008; 53(13):3609-22. (Pubitemid 352020044)
11. Serduc R, Verant P, Vial JC, Farion R, Rocas L, Remy C, et al. In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature. Int J Radiat Oncolo Biolo Phys 2006; 64(5):1519-27.
12. Sabatasso S, Laissue JA, Hlushchuk R, Graber W, Bravin A, Brauer-Krisch E, et al. Microbeam radiation-induced tissue damage depends on the stage of vascular maturation. Int J Radiat Oncol Biol Phys 2011; 80(5):1522-32.
13. Brauer-Krisch E, Serduc R, Siegbahn EA, Le Duc G, Prezado Y, Bravin A, et al. Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue. Mutat Res 2010; 704(1-3):160-6.
14. Regnard P, Brauer-Krisch E, Tropres I, Keyrilainen J, Bravin A, Le Duc G. Enhancement of survival of 9L gliosarcoma bearing rats following intracerebral delivery of drugs in combination with microbeam radiation therapy. Eur J Radiol 2008; 68(3 Suppl): S151-5.
15. Dings RP, Williams BW, Song CW, Griffioen AW, Mayo KH, Griffin RJ. Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells. Int J cancer 2005; 115(2):312-9. (Pubitemid 40586743)
16. Penagaricano J, Griffin R, Corry P, Moros E, Yan Y, Ratanatharathorn V. Spatially fractionated (GRID) therapy for large and bulky tumors. J Ark Med Soc 2009; 105:263-5.
17. Dings RP, Loren M, Heun H, McNiel E, Griffioen AW, Mayo KH, et al. Scheduling of radiation with angiogenesis inhibitors Anginex and Avastin improves therapeutic outcome via vessel normalization. Clin Cancer Res 2007; 13(11):3395-402. (Pubitemid 46944928)
18. Thijssen VL, Postel R, Brandwijk RJ, Dings RP, Nesmelova I, Satijn S, et al. Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci USA 2006; 103(43):15975-80. (Pubitemid 44657577)
19. Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 2000; 60(19):5565-70.
20. Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, et al. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature 1998; 394(6690):287-91. (Pubitemid 28335042)
21. Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003; 300(5622): 1155-9. (Pubitemid 36583102)
22. Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 1999; 59(14):3374-8. (Pubitemid 29334495)
23. Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, et al. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res 1998; 58(24):5686-9. (Pubitemid 29006406)
24. Maj JG, Paris F, Haimovitz-Friedman A, Venkatraman E, Kolesnick R, Fuks Z. Microvascular function regulates intestinal crypt response to radiation. Cancer Res 2003; 63(15):4338-41. (Pubitemid 36951000)
25. Park H-J, Griffin RJ, Hui S, Song CW. Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypo-fractionated radiotherapy (SBRT and SRS). Radiat Res (in press).
26. Mayo KH, van der Schaft DW, Griffioen AW. Designed beta-sheet peptides that inhibit proliferation and induce apoptosis in endothelial cells. Angiogenesis 2001; 4(1):45-51. (Pubitemid 34032036)
27. Dings RP, Mayo KH. A journey in structure-based drug discovery: from designed peptides to protein surface topomimetics as antibiotic and antiangiogenic agents. Acc Chem Res 2007; 40(10):1057-65.
28. Jankovic B, Aquino-Parsons C, Raleigh JA, Stanbridge EJ, Durand RE, Banath JP, et al. Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix. Cytometry Part B, Clin Cytometry 2006; 70(2):45-55.
29. Dings RP, Loren ML, Zhang Y, Mikkelson S, Mayo KH, Corry P, et al. Tumour thermotolerance, a physiological phenomenon involving vessel normalisation. Int J Hypertherm 2011; 27(1): 42-52.
30. Wild R, Ramakrishnan S, Sedgewick J, Griffioen AW. Quantitative assessment of angiogenesis and tumor vessel architecture by computer-assisted digital image analysis: effects of VEGF-toxin conjugate on tumor microvessel density. Microvasc Res 2000; 59(3):368-76. (Pubitemid 30322264)
31. Dings RP, Chen X, Hellebrekers DM, van Eijk LI, Zhang Y, Hoye TR, et al. Design of nonpeptidic topomimetics of antiangiogenic proteins with antitumor activities. J Natl Cancer Inst 2006; 98(13): 932-6. (Pubitemid 44018923)
32. Dings RP, Van Laar ES, Webber J, Zhang Y, Griffin RJ, Waters SJ, et al. Ovarian tumor growth regression using a combination of vascular targeting agents anginex or topomimetic 0118 and the chemotherapeutic irofulven. Cancer Letters 2008; 265(2):270-80.
33. Nettelbeck H, Takacs GJ, Lerch ML, Rosenfeld AB. Microbeam radiation therapy: a Monte Carlo study of the influence of the source, multislit collimator, and beam divergence on microbeams. Med Phys 2009; 36(2):447-56.
34. BräuerKrisch E, Siegbahn EA, Bravin A. GafChromict film measurements for Microbeam Radiation Therapy (MRT). IFMBE Proceedings 2009; 25 IFMBE: P. 174-7.
35. Bräuer-Krisch E, Rosenfeld A, Lerch M, Petasecca M, Akselrod GM, Sykora GJ, et al. Potential High Resolution Dosimeters For MRT. MASR Proceedings 2010; Melbourne, Australia.
36. Uyama A, Kondoh T, Nariyama N, Umetani K, Fukumoto M, Shinohara K, et al. A narrow microbeam is more effective for tumor growth suppression than a wide microbeam: an in vivo study using implanted human glioma cells. J Synchro Radiat 18(Pt 4):671-8.
37. Dings RP, Yokoyama Y, Ramakrishnan S, Griffioen AW, Mayo KH. The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin. Cancer Res 2003; 63(2):382-5. (Pubitemid 36152496)
38. van der Schaft DW, Dings RP, de Lussanet QG, van Eijk LI, Nap AW, Beets-Tan RG, et al. The designer anti-angiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal models. Faseb J 2002; 16(14):1991-3.
39. Mothersill C, Seymour CB. Radiation-induced bystander effects-implications for cancer. Nat Rev Cancer 2004; 4(2):158-64.
40. Hu B, Wu L, Han W, Zhang L, Chen S, Xu A, et al. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 2006; 27(2):245-51. (Pubitemid 43159876)
41. Azzam EI, de Toledo SM, Little JB. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 2003; 22(45):7050-7. (Pubitemid 37386674)
42. Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc Natl Acad Sci USA 2001; 98(2):473-8. (Pubitemid 32105066)
43. Azzam EI, Little JB. The radiation-induced bystander effect: evidence and significance. Hum Exp Toxicol 2004; 23(2):61-5. (Pubitemid 38380014)
44. Mothersill C, Seymour C. Radiation-induced bystander effects: past history and future directions. Radiat Res 2001; 155(6): 759-67. (Pubitemid 32494601)
45. Butterworth KT, McGarry CK, Trainor C, O'Sullivan JM, Hounsell AR, Prise KM. Out-of-field cell survival following exposure to intensity-modulated radiation fields. Int J Radiat Oncol Biol Phys; 79(5):1516-22.
46. Penagaricano JA, Moros EG, Ratanatharathorn V, Yan Y, Corry P. Evaluation of spatially fractionated radiotherapy (GRID) and definitive chemoradiotherapy with curative intent for locally advanced squamous cell carcinoma of the head and neck: initial response rates and toxicity. Int J Rad Oncolo Biolo Phys 76(5): 1369-75.
47. Laissue JA, Geiser G, Spanne PO, Dilmanian FA, Gebbers JO, Geiser M, et al. Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated X rays. Int J Cancer 1998;78(5): 654-60. (Pubitemid 28507193)
48. Asur RS, Sharma S, Whang C-W, Penagaricano P, Kommuru M, Moros EG. Spatially Fractionated Radiation Induces Cytotoxicity and Changes in Gene Expressionin Bystander and Radiation Adjacent Murine Carcinoma Cells. Radiat Res 2012; 177:751-65.