-
1
-
-
0034090097
-
Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
-
Griffioen AW, Molema G. Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 2000;52:237-68.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 237-268
-
-
Griffioen, A.W.1
Molema, G.2
-
2
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, et al. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth. Cell 1997;88:277-85.
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
Fukai, N.4
Vasios, G.5
Lane, W.S.6
-
3
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm T, Folkman J, Browder T, O'Reilly MS. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997;390:404-7.
-
(1997)
Nature
, vol.390
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
O'Reilly, M.S.4
-
4
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004;3:391-400.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
6
-
-
0842311707
-
Discovery and development of anti-angiogenic peptides: A structural link
-
Dings RP, Nesmelova I, Griffioen AW, Mayo KH. Discovery and development of anti-angiogenic peptides: A structural link. Angiogenesis 2003;6:83-91.
-
(2003)
Angiogenesis
, vol.6
, pp. 83-91
-
-
Dings, R.P.1
Nesmelova, I.2
Griffioen, A.W.3
Mayo, K.H.4
-
7
-
-
0038343115
-
Beta-sheet is the bioactive conformation of the anti-angiogenic anginex peptide
-
Dings RP, Arroyo MM, Lockwood NA, Van Eijk LI, Haseman JR, Griffioen AW, et al. Beta-sheet is the bioactive conformation of the anti-angiogenic anginex peptide. Biochem J 2003;23:281-8.
-
(2003)
Biochem J
, vol.23
, pp. 281-288
-
-
Dings, R.P.1
Arroyo, M.M.2
Lockwood, N.A.3
Van Eijk, L.I.4
Haseman, J.R.5
Griffioen, A.W.6
-
8
-
-
0242580732
-
Design of a partial peptide mimetic of anginex with antiangiogenic and anticancer activity
-
Mayo KH, Dings RP, Flader C, Nesmelova I, Hargittai B, van der Schaft DW, et al. Design of a partial peptide mimetic of anginex with antiangiogenic and anticancer activity. J Biol Chem 2003;278:45746-52.
-
(2003)
J Biol Chem
, vol.278
, pp. 45746-45752
-
-
Mayo, K.H.1
Dings, R.P.2
Flader, C.3
Nesmelova, I.4
Hargittai, B.5
van der Schaft, D.W.6
-
9
-
-
0000873890
-
Calixarenes. 13. The conformational properties of calix[4]arenes, calix[6]arenes, calix[8]arenes, and oxacalixarenes
-
Gutsche CD, Bauer LJ. Calixarenes. 13. The conformational properties of calix[4]arenes, calix[6]arenes, calix[8]arenes, and oxacalixarenes. J Am Chem Soc 1985:107:6052-9.
-
(1985)
J Am Chem Soc
, vol.107
, pp. 6052-6059
-
-
Gutsche, C.D.1
Bauer, L.J.2
-
10
-
-
49049122645
-
Calixarenes. 9. Conformational isomers of the ethers and esters of calix[4]arenes
-
Gutsche CD, Dhawan B, Levine JA, No KH, Bauer LJ. Calixarenes. 9. Conformational isomers of the ethers and esters of calix[4]arenes. Tetrahedron 1983;39:406-26.
-
(1983)
Tetrahedron
, vol.39
, pp. 406-426
-
-
Gutsche, C.D.1
Dhawan, B.2
Levine, J.A.3
No, K.H.4
Bauer, L.J.5
-
11
-
-
0036884619
-
The designer anti-angiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal models
-
van der Schaft DW, Dings RP, de Lussanet QG, van Eijk LI, Nap AW, Beets-Tan RG, et al. The designer anti-angiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal models. FASEB J 2002; 16:1991-3.
-
(2002)
FASEB J
, vol.16
, pp. 1991-1993
-
-
van der Schaft, D.W.1
Dings, R.P.2
de Lussanet, Q.G.3
van Eijk, L.I.4
Nap, A.W.5
Beets-Tan, R.G.6
-
12
-
-
0035281805
-
Anginex, a designed peptide that inhibits angiogenesis
-
Griffioen AW, van der Schaft DW, Barendsz-Janson AF, Cox A, Struijker Boudier HA, Hillen HF, et al. Anginex, a designed peptide that inhibits angiogenesis. Biochem J 2001; 354:233-42.
-
(2001)
Biochem J
, vol.354
, pp. 233-242
-
-
Griffioen, A.W.1
van der Schaft, D.W.2
Barendsz-Janson, A.F.3
Cox, A.4
Struijker Boudier, H.A.5
Hillen, H.F.6
-
13
-
-
0037439824
-
The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin
-
Dings RP, Yokoyama Y, Ramakrishnan S, Griffioen AW, Mayo KH. The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin. Cancer Res 2003;63: 382-5.
-
(2003)
Cancer Res
, vol.63
, pp. 382-385
-
-
Dings, R.P.1
Yokoyama, Y.2
Ramakrishnan, S.3
Griffioen, A.W.4
Mayo, K.H.5
-
14
-
-
0347928833
-
Anti-tumor activity of the novel angiogenesis inhibitor anginex
-
Dings RP, van der Schaft DW, Hargittai B, Haseman J, Griffioen AW, Mayo KH. Anti-tumor activity of the novel angiogenesis inhibitor anginex. Cancer Lett 2003;194:55-66.
-
(2003)
Cancer Lett
, vol.194
, pp. 55-66
-
-
Dings, R.P.1
van der Schaft, D.W.2
Hargittai, B.3
Haseman, J.4
Griffioen, A.W.5
Mayo, K.H.6
-
16
-
-
0034125666
-
Quantitative assessment of angiogenesis and tumor vessel architecture by computer-assisted digital image analysis: Effects of VEGF-toxin conjugate on tumor microvessel density
-
Wild R, Ramakrishnan S, Sedgewick J, Griffioen AW. Quantitative assessment of angiogenesis and tumor vessel architecture by computer-assisted digital image analysis: Effects of VEGF-toxin conjugate on tumor microvessel density. Microvasc Res 2000; 59:368-76.
-
(2000)
Microvasc Res
, vol.59
, pp. 368-376
-
-
Wild, R.1
Ramakrishnan, S.2
Sedgewick, J.3
Griffioen, A.W.4
-
18
-
-
1542285103
-
Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein
-
Yin H, Hamilton AD. Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein. Bioorg Med Chem Lett 2004;14:1375-9.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 1375-1379
-
-
Yin, H.1
Hamilton, A.D.2
-
19
-
-
17644365389
-
Terephthalamide derivatives as mimetics of helical peptides: Disruption of the Bcl-x(L)/Bak interaction
-
Yin H, Lee GI, Sedey KA, Rodriguez JM, Wang HG, Sebti SM, et al. Terephthalamide derivatives as mimetics of helical peptides: Disruption of the Bcl-x(L)/Bak interaction. J Am Chem Soc 2005;127:5463-8.
-
(2005)
J Am Chem Soc
, vol.127
, pp. 5463-5468
-
-
Yin, H.1
Lee, G.I.2
Sedey, K.A.3
Rodriguez, J.M.4
Wang, H.G.5
Sebti, S.M.6
-
20
-
-
1842830162
-
Alpha-turn mimetics: Short peptide alpha-helices composed of cyclic metallopentapeptide modules
-
Kelso MJ, Beyer RL, Hoang HN, Lakdawala AS, Snyder JP, Oliver WV, et al. Alpha-turn mimetics: Short peptide alpha-helices composed of cyclic metallopentapeptide modules. J Am Chem Soc 2004;126:4828-42.
-
(2004)
J Am Chem Soc
, vol.126
, pp. 4828-4842
-
-
Kelso, M.J.1
Beyer, R.L.2
Hoang, H.N.3
Lakdawala, A.S.4
Snyder, J.P.5
Oliver, W.V.6
-
22
-
-
0000478078
-
Templates that induce alpha-helical, beta-sheet, and loop conformations
-
Schneider JP, Kelly JW. Templates that induce alpha-helical, beta-sheet, and loop conformations. Chem Rev 1995;95:2169-87.
-
(1995)
Chem Rev
, vol.95
, pp. 2169-2187
-
-
Schneider, J.P.1
Kelly, J.W.2
-
23
-
-
0030811193
-
An extended beta-strand mimic for a larger artificial beta-sheet
-
Nowick JS, Pairish M, Lee IQ, Holmes DL, Ziller JW. An extended beta-strand mimic for a larger artificial beta-sheet. J Am Chem Soc 1997;119:5413-24.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 5413-5424
-
-
Nowick, J.S.1
Pairish, M.2
Lee, I.Q.3
Holmes, D.L.4
Ziller, J.W.5
-
24
-
-
0036783393
-
Design, synthesis, and application of peptide secondary structure mimetics
-
Eguchi M, Kahn M. Design, synthesis, and application of peptide secondary structure mimetics. Mini Rev Med Chem 2002;2:447-62.
-
(2002)
Mini Rev Med Chem
, vol.2
, pp. 447-462
-
-
Eguchi, M.1
Kahn, M.2
-
25
-
-
0037648871
-
Design of beta-turn based therapeutic agents
-
Kee KS, Jois SD. Design of beta-turn based therapeutic agents. Curr Pharm Des 2003;9:1209-24.
-
(2003)
Curr Pharm Des
, vol.9
, pp. 1209-1224
-
-
Kee, K.S.1
Jois, S.D.2
-
26
-
-
0344064881
-
Non-peptide alpha(v)beta(3) antagonists: Identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint
-
Perkins JJ, Duong LT, Femandez-Metzler C, Hartman GD, Kimmel DB, Leu CT, et al. Non-peptide alpha(v)beta(3) antagonists: Identification of potent, chain-shortened RGD mimetics that incorporate a central pyrrolidinone constraint. Bioorg Med Chem Lett 2003; 13:4285-8.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 4285-4288
-
-
Perkins, J.J.1
Duong, L.T.2
Femandez-Metzler, C.3
Hartman, G.D.4
Kimmel, D.B.5
Leu, C.T.6
-
27
-
-
0842281264
-
Lysyl 4-aminobenzoic acid derivatives as potent small molecule mimetics of plasminogen kringle 5
-
Sheppard GS, Kawai M, Craig RA, Davidson DJ, Majest SM, Bell RL, et al. Lysyl 4-aminobenzoic acid derivatives as potent small molecule mimetics of plasminogen kringle 5. Bioorg Med Chem Lett 2004;14:965-6.
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 965-966
-
-
Sheppard, G.S.1
Kawai, M.2
Craig, R.A.3
Davidson, D.J.4
Majest, S.M.5
Bell, R.L.6
-
28
-
-
2342592537
-
Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism
-
Hasegawa A, Cheng X, Kajino K, Berezov A, Murata K, Nakayama T, et al. Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism. Proc Natl Acad Sci U S A 2004;101:6599-604.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 6599-6604
-
-
Hasegawa, A.1
Cheng, X.2
Kajino, K.3
Berezov, A.4
Murata, K.5
Nakayama, T.6
-
29
-
-
2942625510
-
Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: Platelet aggregation and relaxant activities
-
Alexopoulos K, Fatseas P, Melissari E, Vlahakos D, Roumelioti P, Mavromoustakos T, et al. Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: Platelet aggregation and relaxant activities. J Med Chem 2004;47:3338-52.
-
(2004)
J Med Chem
, vol.47
, pp. 3338-3352
-
-
Alexopoulos, K.1
Fatseas, P.2
Melissari, E.3
Vlahakos, D.4
Roumelioti, P.5
Mavromoustakos, T.6
-
30
-
-
0034620783
-
Design of an oligosaccharide scaffold that binds in the minor groove of DNA
-
Xuereb H, Maletic M, Pelczer I, Gildersleeve J, Kahne D. Design of an oligosaccharide scaffold that binds in the minor groove of DNA. J Am Chem Soc 2000;122:1883-90.
-
(2000)
J Am Chem Soc
, vol.122
, pp. 1883-1890
-
-
Xuereb, H.1
Maletic, M.2
Pelczer, I.3
Gildersleeve, J.4
Kahne, D.5
|