Microbeam radiation therapy: A Monte Carlo study of the influence of the source, multislit collimator, and beam divergence on microbeams

Medical Physics

Volumn 36, Issue 2, 2009, Pages 447-456

  Nettelbeck, H ^a   Takacs, G J ^a   Lerch, M L F ^a   Rosenfeld, A B ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Microbeam radiation therapy (MRT); Monte Carlo PENELOPE; Peak to valley dose ratio (PVDR); Radiotherapy

Indexed keywords

LANDFORMS; RADIOTHERAPY;

COMPUTATIONAL STUDIES; DISTRIBUTED SOURCES; MICROBEAM RADIATION THERAPY; MULTISLIT COLLIMATORS; PEAK-TO-VALLEY DOSE RATIOS; PENELOPE; RADIATION TRANSPORT; SYNCHROTRON SOURCE;

MONTE CARLO METHODS;

ARTICLE; BEAM THERAPY; COLLIMATOR; COMPUTER SIMULATION; CONTROLLED STUDY; MICROBEAM RADIATION THERAPY; MONTE CARLO METHOD; PRIORITY JOURNAL; RADIATION DOSE; SYNCHROTRON;

EID: 59249099532     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3049786     Document Type: Article

References (28)

1. P. K. Duffner, M. E. Cohen, M. L. Voorhess, M. H. Macgillivray, M. L. Brecher, A. Panahon, and B. B. Gilani, " Long-term effects of cranial irradiation on endocrine function in children with brain tumors a prospective study.," Cancer 56, 1841-1846 (1985).
2. W. Thomlinson, " Research at the European Synchrotron Radiation Facility medical beamline.," Cell. Mol. Biol. (Paris) 46, 1053-1063 (2000).
3. F. A. Dilmanian, " Response of avian embryonic brain to spatially segmented X-ray microbeams.," Cell. Mol. Biol. (Paris) 47, 485-494 (2001).
4. J. A. Laissue, " The weanling piglet cerebellum: A surrogate for tolerance to MRT (Microbeam Radiation Therapy) in pediatric neuro-oncology., " Proc. SPIE 4508, 65-73 (2001).
5. F. A. Dilmanian, " Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy.," J. Neuro-Oncol. 4, 26-38 (2002).
6. E. Bräuer-Krisch, A. Bravin, M. D. Michiel, M. L. F. Lerch, A. B. Rosenfeld, J. Stepanek, and J. A. Laissue, " MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility.," Med. Phys. 30, 583-589 (2003).
7. E. Bräuer-Krisch, A. Bravin, L. Zhang, E. Siegbahn, J. Stepanek, H. Blattmann, D. N. Slatkin, J. O. Gebbers, M. Jasmin, and J. A. Laissue, " Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility.," Rev. Sci. Instrum. 76, 064303 (2005).
8. M. D. Felici, R. Felici, M. S. del Rio, C. Ferrero, T. Bacarian, and F. A. Dilmanian, " Dose distribution from x-ray microbeam arrays applied to radiation therapy: An EGS4 monte carlo study.," Med. Phys. 32, 2455-2463 (2005).
9. J. A. Laissue, H. Blattmann, H. P. Wagner, M. A. Grotzer, and D. N. Slatkin, " Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae.," Dev. Med. Child Neurol. 49, 577-581 (2007).
10. J. Spiga, E. A. Siegbahn, E. Bräuer-Krisch, P. Randaccio, and A. Bravin, " The GEANT4 toolkit for microdosimetry calculations: Application to microbeam radiation therapy MRT.," Med. Phys. 34, 4322-4330 (2007).
11. H. J. Curtis, " The use of deuteron microbeam for simulating the biological effects of heavy cosmic-ray particles.," Radiat. Res., Suppl. 7, 250-257 (1967).
12. H. J. Curtis, " The interpretation of microbeam experiments for manned space flight.," Radiat. Res., Suppl. 7, 258-264 (1967).
13. D. N. Slatkin, P. O. Spanne, F. A. Dilmanian, and M. Sandborg, " Microbeam radiation therapy.," Med. Phys. 19, 1395-1400 (1992).
14. J. A. Laissue, N. Lyubimova, H. P. Wagner, D. W. Archer, D. N. Slatkin, M. D. Michiel, C. Nemoz, M. Renier, E. Brauer, P. O. Spanne, " Microbeam radiation therapy.," Proc. SPIE 3770, 38-45 (1999).
15. F. A. Dilmanian, " X-ray microbeams: Tumor therapy and central nervous system research.," Nucl. Instrum. Methods Phys. Res. A 548, 30-37 (2005).
16. E. A. Siegbahn, J. Stepanek, E. Bräuer-Krisch, and A. Bravin, " Determination of dosimetrical quantities used in microbeam radiation therapy (MRT) with Monte Carlo simulations.," Med. Phys. 33, 3248-3259 (2006).
17. M. Miura, H. Blattmann, E. Bräuer-Krisch, A. Bravin, A. L. Hanson, M. M. Nawrocky, N. Lyubimova, P. L. Micca, D. N. Slatkin, and J. Laissue, " Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams.," Br. J. Radiol. 79, 71-75 (2006).
18. H. M. Smilowitz, " Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosar-comas.," J. Neuro-Oncol. 78, 135-143 (2006).
19. P. Regnard, " Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: Balance between curing and sparing.," Phys. Med. Biol. 53, 861-878 (2008).
20. J. A. Laissue, " Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler- generated x rays.," Int. J. Cancer 78, 654-660 (1998).
21. D. N. Slatkin, P. O. Spanne, F. A. Dilmanian, J. O. Gebbers, and J. A. Laissue, " Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler.," Proc. Natl. Acad. Sci. U.S.A. 92, 8783-8787 (1995).
22. D. W. Archer, U.S. Patent No. 5771270, 23 June (1998).
23. I. Orion, A. B. Rosenfeld, F. A. Dilmanian, F. Telang, B. Ren, and Y. Namito, " Monte Carlo simulation of dose distributions from a synchrotron-produced microplanar beam array using the EGS4 code system.," Phys. Med. Biol. 45, 2497-2508 (2000).
24. J. Stepanek, H. Blattmann, J. A. Laissue, N. Lyubimova, M. D. Michiel, and D. N. Slatkin, " Physics study of microbeam radiation therapy with PSI-version of Monte Carlo code GEANT as a new computational tool.," Med. Phys. 27, 1664-1675 (2000).
25. E. A. Siegbahn, E. Bräuer-Krisch, J. Stepanek, H. Blattmann, J. A. Laissue, and A. Bravin, " Dosimetric studies of microbeam radiation therapy (MRT) with Monte Carlo simulations.," Nucl. Instrum. Methods Phys. Res. A 548, 54-58 (2005).
26. F. Salvat, J. M. Fernández-Varea, and J. Sempau, PENELOPE-A Code System for Monte Carlo Simulation of Electron and Photon Transport (OECD Nuclear Energy Agency, Issy-les-Moulineaux, France, 2003).
27. J. Sempau, J. M. Fernández-Varea, E. Acosta, and F. Salvat, " Experimental benchmarks of the Monte Carlo code PENELOPE.," Nucl. Instrum. Methods Phys. Res. B 207, 107-123 (2003).
28. P. Coan, E. Pagot, S. Fiedler, P. Cloetens, J. Baruchel, and A. Bravin, " Phase-contrast X-ray imaging combining free space propagation and Bragg Diffraction.," J. Synchrotron Radiat. 12, 241-245 (2005).