Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 14, 2012, Pages 4303-4309

  Shi, Genbin ^a   Shaw, Gary ^a   Li, Yue ^b   Wu, Yan ^b   Yan, Honggao ^b   Ji, Xinhua ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Michigan State University   (United States)

Author keywords

Antibacterial; Bisubstrate; Folate; HPPK; Pterin

Indexed keywords

2 (MERCAPTO ETHYL)CARBAMIC ACID TERT BUTYL ESTER; 2 AMINO 7,7 DIMETHYL 4 OXO 3,4,7,8 TETRAHYDRO PTERIDINE 6 CARBOXYLIC ACID; 2 AMINO 7,7 DIMETHYL 4 OXO 3,4,7,8 TETRAHYDRO PTERIDINE 6 CARBOXYLIC ACID [2 [2 [5 (6 AMINO PURIN 9 YL) 3,4 DIHYDROXY TETRAHYDRO FURAN 2 YLMETHANESULFONYL]ETHYLCARBAMOYL]ETHYL]AMIDE; 2'3' O ISOPROPYLIDENE 5' O TOLUENE 4 SULFONYL ADENOSINE; 3 AMINO N [2 [5 (6 AMINO PURIN 9 YL) 3,4 DIHYDROXY TETRAHYDRO FURAN 2 YLMETHANESULFONYL]ETHY]PROPIONAMIDE; 6 HYDROXYMETHYL 7,8 DIHYDROPTERIN PYROPHOSPHOKINASE; 9 [6 (2 AMINO ETHANESULFONYLMETHYL) 2,2 DIMETHYL TETRAHYDRO FURO[3,4 D][1,3]DIOXOL 4 YL] 9H PURIN 6 YLAMINE; [2 [2 [6 (6 AMINO PURIN 9 YL) 2,2 DIMETHYL TETRAHYDRO FURO[3,4 D][1,3]DIOXOL 4 YLMETHANESULFONYL]ETHYLCARBAMOYL]ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [2 [6 (6 AMINO PURIN 9 YL) 2,2 DIMETHYL TETRAHYDRO FURO[3,4 D][1,3]DIOXOL 4 YLMETHANESULFONYL]ETHYL]CARBAMIC ACID TERT BUTYL ESTER; ADENINE; ADENOSINE TRIPHOSPHATE MAGNESIUM; AMINO ACID; AMINO ACID E77; BISUBSTRATE ANALOG INHIBITOR; ENZYME INHIBITOR; PHOSPHOTRANSFERASE; RIBOSE; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; HYDROGEN BOND; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ADENINE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHOTRANSFERASES; ENZYME INHIBITORS; HYDROGEN BONDING; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PTERINS; SUBSTRATE SPECIFICITY;

EID: 84863201623     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.060     Document Type: Article

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