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Volumn 20, Issue 14, 2012, Pages 4422-4429

Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups

(7) Tu, Zhude a Wang, Wei a Cui, Jinquan a Zhang, Xiang a Lu, Xiaoxia a Xu, Jinbin a Parsons, Stanley M b

a WASHINGTON UNIVERSITY (United States)

b UNIVERSITY OF CALIFORNIA (United States)

Author keywords

Receptor; CNS disorders; Parkinson's disease; VAChT; Vesamciol

Indexed keywords

[1' (4 FLUOROBENZOYL) 4' HYDROXY (1,3' BIPIPERIDIN) 4 YL] (4 METHOXYPHENYL)METHANONE OXALIC ACID; [1' (4 METHOXYBENZOYL) 4' HYDROXY (1,3' BIPIPERIDIN) 4 YL] (4 METHOXYPHENYL)METHANONE OXALIC ACID; [1' BENZOYL 4' HYDROXY (1,3' BIPIPERIDIN) 4 YL] (4 FLUOROPHENYL)METHANONE OXALIC ACID; [1' BENZOYL 4' HYDROXY (1,3' BIPIPERIDIN) 4 YL] (4 METHOXYPHENYL)METHANONE OXALIC ACID; [3' HYDROXY 1' (5 METHYLTHIOPHENE 2 CARBONYL)(1,4' BIPIPERIDIN) 4 YL] (4 METHOXYPHEYL)METHANONE OXALIC ACID; [3' HYDROXY 1' (THIOPHENE 2 CARBONYL)(1,4' BIPIPERIDIN) 4 YL] (4 METHOXYPHEYL)METHANONE OXALIC ACID; [4 (4 FLUOROBENZOYL) 3' HYDROXY [1,4' BIPIPERIDIN] 1' YL] (3 METHYLTHIOPHEN 2 YL)METHANONE OXALIC ACID; [4 (4 FLUOROBENZOYL) 3' HYDROXY [1,4' BIPIPERIDIN] 1' YL](THIOPHEN 2 YL)METHANONE OXALIC ACID; [4 (4 FLUOROBENZOYL) 4' HYDROXY (1,3' BIPIPERIDIN) 1' YL] (3 METHYLTHIOPHEN 2 YL)METHANONE OXALIC ACID; [4 (4 FLUOROBENZOYL) 4' HYDROXY (1,3' BIPIPERIDIN) 1' YL] (4 METHOXYPHENYL)METHANONE OXALIC ACID; [4 (4 FLUOROBENZOYL) 4' HYDROXY (1,3' BIPIPERIDIN) 1' YL] (5 METHYLTHIOPHEN 2 YL)METHANONE OXALIC ACID; [4 (4 FLUOROBENZOYL) 4' HYDROXY (1,3' BIPIPERIDIN) 1' YL] (PYRIDIN 3 YL)METHANONE OXALIC ACID; [4 (4 FLUOROBENZOYL) 4' HYDROXY (1,3' BIPIPERIDIN) 1' YL](THIOPAN 2 YL)METHANONE OXALIC ACID; [4' HYDROXY (1,3' BIPIPERIDINE) 1',4 DIYL]BIS (4 FLUOROPHENYL)METHANONE OXALIC ACID; [4' HYDROXY 1' (3 METHYLTHIOPHENE 2 CARBONYL) (1,3' BIPIPERIDIN) 4 YL] (4 METHOXYPHENYL)METHANONE OXALIC ACID; [4' HYDROXY 1' (THIOPENE 2 CARBONYL) (1,3' BIPIPERIDIN) 4 YL] (4 METHOXYPHENYL)METHANONE OXALIC ACID; CARBONYL DERIVATIVE; CHOLINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VESAMICOL; VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMINES; CARBON RADIOISOTOPES; CELL LINE, TUMOR; FLUORINE RADIOISOTOPES; HUMANS; KETONES; KINETICS; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIOPHARMACEUTICALS; STRUCTURE-ACTIVITY RELATIONSHIP; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 84863185156 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.05.045 Document Type: Article

Times cited : (18)

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