Measurement of functional cholinergic innervation in rat heart with a novel vesamicol receptor ligand

Nuclear Medicine and Biology

Volumn 23, Issue 7, 1996, Pages 923-926

  Coffeen, Paul R ^a   Efange, S M N ^a   Haidet, George C ^a   McKnite, Scott ^a   Langason, Rosemary B ^a   Khare, A B ^a   Pennington, Jennifer ^a   Lurie, Keith G ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Cardiac Arrhythmia Center   (United States)

Author keywords

Acetylcholine; Autonomic nervous system; Cardiac conduction system; Receptor autoradiography; Vesamicol

Indexed keywords

IODINE 125; META IODOBENZYLTROZAMICOL; UNCLASSIFIED DRUG; VESAMICOL DERIVATIVE; VESAMICOL RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; HEART; INTRAVENOUS DRUG ADMINISTRATION; PARASYMPATHETIC INNERVATION; RAT;

ACETYLCHOLINESTERASE; ANIMALS; AUTORADIOGRAPHY; FEMALE; HEART; HEART CONDUCTION SYSTEM; INJECTIONS, INTRAVENOUS; IODINE RADIOISOTOPES; IODOBENZENES; MYOCARDIUM; PIPERIDINES; RATS; RATS, INBRED F344; RECEPTORS, CHOLINERGIC;

EID: 0030271671     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(96)00132-1     Document Type: Article

References (13)

1. 1. Satohst K., Armstrong, D. H. and Fibiger H. C. (1983) A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistry. Brain Res. Bull. 11, 693-720.
2. 2. Marshall I. G. and Parsons S. M. (1987) The vesicular acetylcholine transport system. Trends Neurol. Sci. 10, 174-177.
3. 125I]MIBT): Potential radioligand for mapping central cholinergic innervation. J. Med. Chem. 36, 1754-1760.
4. 4. Altar C. A. and Marien M. R. (1988) Vesamicol binding in the brain: Autoradiographic distribution, pharmacology, and effects of cholinergic lesions. Synapse 2, 486-493.
5. 5. Lurie K. G., Dutton L. A. and Matschinsky E. M. (1991) Measurement of extracellular space in the rabbit AV node. J. Histochem. Cytochem. 39, 1671-1677.
6. 6. El-Badawi A. and Stenk E. A. (1967) Histochemical methods for separate, consecutive, and simultaneous demonstration of acetylcholinesterase and norepinephrine in cryostat section. J. Histochem. Cytochem. 15, 580-588.
7. 7. Correa-Rotter R., Mariash C. N. and Rosenberg M. E. (1992) Loading and transfer control for Northern hybridization. Biotechniques 12, 154-158.
8. 125I] standards for quantitative receptor autoradiography. J Neurosci. Methods 25, 75-82.
9. 9. Lurie K. G., Dutton J. and Wiegn P. (1992) Regional distribution of ECS in contractile and conductive elements of rat and rabbit heart. Am. J. Physiol. 32, H168-176.
10. 10. Marien M. R., Richand J. W., Allairle C. et al. (1991) Suppression of in vivo neostriatal acetylcholine release by vesamicol: Evidence for a functional role of vesamicol receptors in brain. J. Neurochem. 57, 1878-1883.
11. 11. Pemberton K. E., Prior C. and Marshall I. G. (1992) The effects of vesamicol on trains of endplate currents and on focally recorded nerve terminal currents at mammalian neuromuscular junctions. Br. J. Pharmacol. 105, 113-118.
12. 12. Prior C., Tian L., Dempster J. and Marshall I. G. (1995) Prejunctional actions of muscle relaxants: Synaptic vesicles and transmitter mobilization as sites of action. Gen. Pharmacol. 26, 659-666.
13. 2 acetylcholine interactions: PET studies of the vesamicol receptor. Neuroreport 4, 1311-1314.