Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter

Journal of Medicinal Chemistry

Volumn 53, Issue 7, 2010, Pages 2825-2835

  Efange, Simon M N ^a,e   Khare, Anil B ^a   Von Hohenberg, Krystyna ^a   MacH, Robert H ^b,d   Parsons, Stanley M ^c   Tu, Zhude ^a,d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF BUEA   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZOYL 4 (5 BROMOTHIEN 2 YL)CARBONYLPIPERIDINE; 1 BENZOYL 4 (5 IODOTHIEN 2 YL)CARBONYLPIPERIDINE; 1 BENZOYL 4 (THIEN 2 YL)CARBONYLPIPERIDINE; 2 (4 BENZOYL 4 PHENYLPIPERIDINYL)CYCLOHEXANOL; 2 (4 BENZOYLPIPERIDINYL)CYCOHEXANOL; 2 [4 (4 BROMOBENZOYL)PIPERIDINYL]CYCOHEXANOL; 2 [4 (4 FLUOROBENZOYL)PIPERIDINYL]CYCOHEXANOL; 2 [4 (5 BROMOTHIEN 2 YL)CARBONYLPIPERIDINYL]CYCLOHEXANOL; 2 [4 (5 IODOTHIEN 2 YL)CARBONYLPIPERIDINYL]CYCLOHEXANOL; 2 [4 (THIEN 2 YL)CARBONYLPIPERIDINYL]CYCLOHEXANOL; 4 (5 BROMOTHIEN 2 YL)CARBONYLPIPERIDINE; 4 (5 IODOTHIEN 2 YL)CARBONYLPIPERIDINE; 4 (THIEN 2 YL)CARBONYLIPERIDINE; 5 AMINO 3 [4 (4 FLUOROBENZOYL)PIPERIDINYL] 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; 5 AMINO 3 [4 (THIEN 2 YL)CARBONYLPIPERIDYL] 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; 8 AMINO 3 [4 (THIEN 2 YL)CARBONYLPIPERIDYL] 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; BENZENE DERIVATIVE; BENZOVESAMICOL; CARBONYL DERIVATIVE; PIPERIDINE DERIVATIVE; TRANS 2 HYDROXY 3 (4 PHENYLACETYL 4 PHENYLPIPERIDINYL) 1,2,3,4 TETRAHYDRONAPHTHALENE; TRANS 2 HYDROXY 3 [4 (THIEN 2 YL)CARBONYLPIPERIDINYL] 1,2,3,4 TETRAHYDRONAPHTHALENE; TRANS 3 (4 BENZOYL 4 PHENYLPIPERIDINYL) 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; TRANS 3 (4 FLUOROBENZOYL 4 PHENYLPIPERIDINYL) 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; TRANS 3 [4 (4 FLUOROBENZOYL)PIPERIDINYL] 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; TRANS 3 [4 (5 BROMOTHIENYLCARBONYL)PIPERIDINYL] 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; TRANS 3 [4 (5-IODOTHIENYLCARBONYL)PIPERIDINYL] 2 HYDROXY 1,2,3,4 TETRAHYDRONAPHTHALENE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VESAMICOL; VESICULAR ACETYLCHOLINE TRANSPORTER;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; DRUG SYNTHESIS; HALOGENATION; IN VITRO STUDY; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; DRUG DISCOVERY; GUINEA PIGS; INHIBITORY CONCENTRATION 50; PIPERIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TORPEDO; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS;

EID: 77950583227     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9017916     Document Type: Article

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