Progressive activation of CD127+132- recent thymic emigrants into terminally differentiated CD127-132+ T-cells in HIV-1 infection

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Sasson, Sarah C ^a,b   Zaunders, John J ^b   Seddiki, Nabila ^a,b   Bailey, Michelle ^a,b   McBride, Kristin ^a,b   Koelsch, Kersten K ^a,b   Merlin, Kate M ^b   Smith, Don E ^a   Cooper, David A ^a,b   Kelleher, Anthony D ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; KI 67 ANTIGEN; PROTEIN BCL 2; VIRUS DNA; IL2RG PROTEIN, HUMAN; INTERLEUKIN 7 RECEPTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; CORRELATIONAL STUDY; DNA CONTENT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD; CASE CONTROL STUDY; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; T LYMPHOCYTE; THYMUS; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; HIV INFECTIONS; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 84863156375     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031148     Document Type: Article

References (39)

1. Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, et al. (1994) Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 180: 1955-1960.
2. von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SE, et al. (1995) Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181: 1519-1526.
3. Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, et al. (1998) IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol 161: 5909-5917.
4. Webb LM, Foxwell BM, Feldmann M, (1999) Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool. Immunology 98: 400-405.
5. Seddon BaZ, R, (2002) TCR and IL-7 Receptor Signals Can Operate Independantly or Synergize to Promote Lymphopenia-Induces Expansion of Naive T cells. Journal of Immunology pp. 3752-3759.
6. Bolotin E, Annett G, Parkman R, Weinberg K, (1999) Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant 23: 783-788.
7. Fry TJ, Connick E, Falloon J, Lederman MM, Liewehr DJ, et al. (2001) A potential role for interleukin-7 in T-cell homeostasis. Blood 97: 2983-2990.
8. Napolitano LA, Grant RM, Deeks SG, Schmidt D, De Rosa SC, et al. (2001) Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7: 73-79.
9. Rosenberg SA, Sportes C, Ahmadzadeh M, Fry TJ, Ngo LT, et al. (2006) IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells. J Immunother 29: 313-319.
10. Sportes C, Hakim FT, Memon SA, Zhang H, Chua KS, et al. (2008) Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med 205: 1701-1714.
11. Levy Y, Lacabaratz C, Weiss L, Viard JP, Goujard C, Lelièvre JD, Boué F, Molina JM, Rouzioux C, Avettand-Fénoêl V, Croughs T, Beq S, Thiébaut R, Chêne G, Morre M, Delfraissy JF, (2009) Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest 119.
12. Sereti I, Dunham RM, Spritzler J, Aga E, Proschan MA, et al. (2009) IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood 113: 6304-6314.
13. Carini C, McLane MF, Mayer KH, Essex M, (1994) Dysregulation of interleukin-7 receptor may generate loss of cytotoxic T cell response in human immunodeficiency virus type 1 infection. Eur J Immunol 24: 2927-2934.
14. MacPherson PA, Fex C, Sanchez-Dardon J, Hawley-Foss N, Angel JB, (2001) Interleukin-7 receptor expression on CD8(+) T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy. J Acquir Immune Defic Syndr 28: 454-457.
15. Sasson SC, Zaunders JJ, Zanetti G, King EM, Merlin KM, et al. (2006) Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection. J Infect Dis 193: 505-514.
16. Colle JH, Moreau JL, Fontanet A, Lambotte O, Joussemet M, et al. (2006) Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients-effects of antiretroviral therapy. J Acquir Immune Defic Syndr 42: 277-285.
17. Park JH, Yu Q, Erman B, Appelbaum JS, Montoya-Durango D, et al. (2004) Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity 21: 289-302.
18. Alves NL, van Leeuwen EM, Derks IA, van Lier RA, (2008) Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling. J Immunol 180: 5201-5210.
19. Faller EM, McVey MJ, Kakal JA, MacPherson PA, (2006) Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein. J Acquir Immune Defic Syndr 43: 257-269.
20. Faller E, Kakal J, Kumar R, Macpherson P, (2009) IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells. Int Immunol 21: 203-216.
21. Jiang Q, Benbernou N, Chertov O, Khaled AR, Wooters J, et al. (2004) IL-7 induces tyrosine phosphorylation of clathrin heavy chain. Cell Signal 16: 281-286.
22. Henriques CM, Rino J, Nibbs RJ, Graham GJ, Barata JT, (2010) IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells. Blood 115: 3269-3277.
23. Vranjkovic A, Crawley AM, Gee K, Kumar A, Angel JB, (2007) IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells. Int Immunol 19: 1329-1339.
24. Vingerhoets J, Bisalinkumi E, Penne G, Colebunders R, Bosmans E, et al. (1998) Altered receptor expression and decreased sensitivity of T-cells to the stimulatory cytokines IL-2, IL-7 and IL-12 in HIV infection. Immunol Lett 61: 53-61.
25. Mussini C, Pinti M, Borghi V, Nasi M, Amorico G, et al. (2002) Features of 'CD4-exploders', HIV-positive patients with an optimal immune reconstitution after potent antiretroviral therapy. Aids 16: 1609-1616.
26. Zaunders JJ, Moutouh-de Parseval L, Kitada S, Reed JC, Rought S, et al. (2003) Polyclonal proliferation and apoptosis of CCR5+ T lymphocytes during primary human immunodeficiency virus type 1 infection: regulation by interleukin (IL)-2, IL-15, and Bcl-2. J Infect Dis 187: 1735-1747.
27. Zhang SY, Zhang Z, Fu JL, Kang FB, Xu XS, et al. (2009) Progressive CD127 down-regulation correlates with increased apoptosis of CD8 T cells during chronic HIV-1 infection. Eur J Immunol 39: 1425-1434.
28. Smith DE, Kaufmann GR, Kahn JO, Hecht FM, Grey PA, et al. (2003) Greater reversal of CD4+ cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine, and nelfinavir before complete HIV type 1 seroconversion. AIDS Res Hum Retroviruses 19: 189-199.
29. French M, Amin J, Roth N, Carr A, Law M, et al. (2002) Randomized, open-label, comparative trial to evaluate the efficacy and safety of three antiretroviral drug combinations including two nucleoside analogues and nevirapine for previously untreated HIV-1 Infection: the OzCombo 2 study. HIV Clin Trials 3: 177-185.
30. Zaunders JJ, Dyer WB, Wang B, Munier ML, Miranda-Saksena M, et al. (2003) Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term non-progressor and in CMV infection. Blood.
31. Hazenberg MD, Otto SA, Cohen Stuart JW, Verschuren MC, Borleffs JC, et al. (2000) Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med 6: 1036-1042.
32. Suzuki K, Shijuuku T, Fukamachi T, Zaunders J, Guillemin G, et al. (2005) Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region. J RNAi Gene Silencing 1: 66-78.
33. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, et al. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203: 1693-1700.
34. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4(+) T reg cells. J Exp Med 203: 1701-1711.
35. Lang KS, Recher M, Navarini AA, Harris NL, Lohning M, et al. (2005) Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation. Eur J Immunol 35: 738-745.
36. Fuller MJ, Hildeman DA, Sabbaj S, Gaddis DE, Tebo AE, et al. (2005) Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. J Immunol 174: 5926-5930.
37. Radziewicz H, Ibegbu CC, Fernandez ML, Workowski KA, Obideen K, et al. (2007) Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol 81: 2545-2553.
38. Rathmell JC, Farkash EA, Gao W, Thompson CB, (2001) IL-7 enhances the survival and maintains the size of naive T cells. J Immunol 167: 6869-6876.
39. Tan JT, Dudl E, LeRoy E, Murray R, Sprent J, et al. (2001) IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98: 8732-8737.