Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam.

Cancer Chemotherapy and Pharmacology

Volumn 65, Issue 4, 2010, Pages 719-726

  Iwasaki, Hironori ^a   Okabe, Takafumi ^a   Takara, Kensaku ^a   Toda, Takayoshi ^b   Shimatani, Masayuki ^a   Oku, Hirosuke ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b UNIVERSITY HOSPITAL OF THE RYUKYUS   (Japan)

Author keywords

Accumulation; Alkaloid; Antitumor; Benzo c phenanthridinium; Nitidine; Toddalia asiatica Lam.

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; BENZO[C]PHENANTHRIDINE DERIVATIVE; DEMETHYLNITIDINE; DIHYDRONITIDINE; NITIDINE; UNCLASSIFIED DRUG; BENZOPHENANTHRIDINE DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN BAX; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DETERIORATION; DRUG EFFICACY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MALE; MASS SPECTROMETRY; MEDICINAL PLANT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TODDALIA ASIATICA; TUMOR XENOGRAFT; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; C57BL MOUSE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GENE EXPRESSION; GENETICS; LUNG TUMOR; NUDE MOUSE; PATHOLOGY; RUTACEAE; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOPHENANTHRIDINES; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; MOLECULAR STRUCTURE; PLANTS, MEDICINAL; RUTACEAE; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 75749123095     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-1077-7     Document Type: Article

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