Investigations on gastroprotective effect of citalopram, an antidepressant drug against stress and pyloric ligation induced ulcers

Pharmacological Reports

Volumn 63, Issue 6, 2011, Pages 1413-1426

  Saxena, Bhagawati ^a   Singh, Sanjay ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

Antidepressant; Citalopram; Gastroprotective; Nitric oxide; Prostaglandin

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); CITALOPRAM; CORTICOSTERONE; GLIBENCLAMIDE; HEXOSAMINE; INDOMETACIN; LIPID PEROXIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRITE; PROSTAGLANDIN; PROSTAGLANDIN E2; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; GASTROPROTECTIVE ACTIVITY; IMMOBILIZATION STRESS; LIPID BLOOD LEVEL; LIPID PEROXIDATION; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PROSTAGLANDIN BLOOD LEVEL; PYLORUS LIGATION; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; STOMACH ULCER; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 84863146666     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/s1734-1140(11)70705-8     Document Type: Article

References (55)

1. Adeyemi EO, Bastaki SA, Chandranath IS, Hasan MY, Fahim M, Adem A: Mechanisms of action of leptin in preventing gastric ulcer. World J Gastroenterol, 2005, 11, 4154-4160. (Pubitemid 41086864)
2. Andrade SF, Lemos M, Comunello E, Noldin VF, Filho VC, Niero R: Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models. J Ethnopharmacol, 2007, 113, 252-257. (Pubitemid 47239249)
3. Andrage C, Sandarsh S, Chethan KB, Nagesh KS: Serotonin reuptake inhibitors antidepressants and abnormal bleeding: A review for clinicians and a reconsideration of mechanisms. J Clin Psychiatry, 2010, 71, 1565-1575.
4. Andrews FJ, Malcontenti C, O'Brien PE: Sequence of gastric mucosal injury following ischemia and reperfusion. Role of reactive oxygen metabolites. Dig Dis Sci, 1992, 37, 1356-1361.
5. Arrieta J, Benitez J, Flores E, Castillo C, Navarrete A: Purification of gastroprotective triterpenoids from stem bark of Amphipterygium adstringens; roles of prostaglandins, sulphidryls, nitric oxide and capsaicin neurons. Planta Med, 2003, 69, 905-909. (Pubitemid 38005445)
6. Avila JR, de La Lastra CA, Martin MJ, Motilva V, Luque I, Delgado D, Esteban J, Herrerias J: Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats. Inflamm Res, 1996, 45, 83-88. (Pubitemid 26064409)
7. Buckingham J, Cowell A, Gillies G, Herbison A, Steel J: The neuroendocrine system: anatomy, physiology and responses to stress. In: Stress and Stress Hormones and the Immune System. Ed. Buckingham J, Cowell A, Gillies G, John Wiley and Sons, London, 1997, 10-47.
8. Chamoun F, Burne M, O'Donnell M, Rabb H: Pathophysiologic role of selectins and their ligands in ischemia reperfusion injury. Front Biosci, 2000, 5, E103-109.
9. Chandranath SI, Bastaki SMA, Singh JA: Comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol and indomethacininduced gastric lesions in the rat. Clin Exp Pharmacol Physiol, 2002, 29, 173-180. (Pubitemid 34233971)
10. Chaouloff F: Serotonin, stress and corticoids. J Psychopharmacol, 2000, 14, 139-151.
11. Cho CH, Ogle CW: The pharmacological differences and similarities between stress- and ethanol-induced gastric mucosal damage. Life Sci, 1992, 51, 1833-1842.
12. Crawford AS, White JG: Celecoxib-induced upper gastrointestinal hemorrhage and ulceration. South Med J, 2002, 95, 1444-1446. (Pubitemid 36207436)
13. Debnath PK, Gode KD, Das GD, Sanyal AK: Effect of propranolol on gastric secretion in albino rats, Br J Pharmacol, 1974, 51, 213-216.
14. Dische Z, Borentrend E: Determination of hexosamines. J Biol Chem, 1948, 184, 517.
15. Feldman F, Friedman LS, Sleisenger MH: Sleisenger and Fordtran's Gastrointestinal and Liver Disease, WB Saunders Co, Philadelphia, 2002, 615.
16. Fernandez de la Gandara F, Casas Carnicero J, Velasco Martin A: Effects of antidepressants on alcohol-induced gastric mucosal injury in rats. Methods Find Exp Clin Pharmacol, 1989, 11, 635-639. (Pubitemid 19276010)
17. Gabry KE, Chrousos GP, Rice KC, Mostafa RM, Sternberg E, Negrao AB, Webster EL et al.: Marked suppression of gastric ulcerogenesis and intestinal responses to stress by a novel class of drugs. Mol Psychiatry, 2002, 7, 474-483. (Pubitemid 34712899)
18. Garcia ML, Hanner M, Knaus HG, Koch R, Schmalhofer W, Slaughter RS, Kaczorowski GJ: Pharmacology of potassium channels. Adv Pharmacol, 1997, 39, 425-471.
19. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR: Analysis of nitrate, nitrite, and ['5N] nitrate in biological fluids. Anal Biochem, 1982, 126, 131-138. (Pubitemid 13203451)
20. Guldahl M: The effect of trimipramine (Surmontil r) on masked depression in patients with duodenal ulcer. A double-blind study. Scand J Gastroenterol, 1977, Suppl 43, 27-31.
21. Hatzinger M: Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression. World J Biol Psychiatry, 2000, 1, 105-111.
22. Hernandez DE, Xue BG: Imipramine prevents stress gastric glandular lesions in rats. Neurosci Lett, 1989, 103, 209-212. (Pubitemid 19201254)
23. Hooderwerf WA, Pasricha PJ: Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease. In: Goodman and Gilman's the Pharmacological Basis of Therapeutics. Ed. Brunton L, Mc Graw-Hill, New York, 2006, 967-981.
24. Jensen J, Jessop D, Harbuz M, Mork A, Sanchez C, Mikkelsen J: Acute and long-term treatments with the selective serotonin inhibitor citalopram modulates the HPA axis activity at different levels in male rats. J Neuroendocrinol, 1999, 11, 465-471. (Pubitemid 29243770)
25. Joel M: Allostatic load. Eur J Pharmacol, 2008, 583, 173.
26. Jorgensen H, Knigge U, Kjaer A, Moller M, Warberg J: Serotonergic stimulation of corticotrophin-releasing hormone and pro-opiomelanocortin gene expression. J Neuroendocrinol, 2002, 14, 788-795. (Pubitemid 35203476)
27. Haleem DJ: Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats. Pharmacol Rep, 2011, 63, 888-897.
28. Katayama S, Shionoya H, Ohtake S: A new method for extraction of extravagated dye in the skin and the influence of fasting stress on passive cutaneous anaphylaxis in guinea pigs and rats. Microbiol Immunol, 1978, 22, 89-101. (Pubitemid 8346231)
29. Keshavarzian A, Wibowo A, Gordon JH, Fields JZ: MPTP-induced duodenal ulcers in rat. Prevention by reuptake blockers for serotonin and norepinephrine, but not dopamine. Gastroenterology, 1990, 98, 554-560. (Pubitemid 20069689)
30. Konturek PC: Physiological, immunohistochemical and molecular aspects of gastric adaptation to stress, aspirin and to H. pylori-derived gastrotoxins. J Physiol Pharmacol, 1997, 48, 3-42.
31. La Casa C, Villegas I, Alarcon de la Lastra C, Motilva V, Martín Calero MJ: Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol, 2000, 71, 45-53. (Pubitemid 30440651)
32. Li Y, Wang WP, Wang HY, Cho CH: Intragastric administration of heparin enhances gastric ulcer healing through a nitric oxide dependent mechanism in rats. Eur J Pharmacol, 2000, 399, 205-214. (Pubitemid 30407042)
33. Loke YK, Trivedi AN, Singh S: Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther, 2008, 27, 31-40. (Pubitemid 350212624)
34. Lowry OH, Rosebrough NJ, Fart AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem, 1951, 193, 165-175.
35. Lucas CE, Sugawa C, Riddle J, Rector F, Rosenberg B, Walt AJ: Natural history and surgical dilemma of "stress"gastric bleeding. Arch Surg, 1971, 102, 266-273.
36. Maes M, Meltzer Y, D'Hondt P, Cosyns P, Blockx P: Effects of serotonin precursors on the negative feedback effects of glucocorticoids on hypothalamic-pituitary-adrenal axis function in depression. Psychoneuroendocrinology, 1995, 20, 149-167. (Pubitemid 24366197)
37. Nemeroff C, Winderlov E, Bissette G, Walleus H, Karlsson I, Eklund K, Kilts C, Loosen P, Vale W: Elevated concentration of CSF CRF immunoreactivity in depressed patients. Science, 1984, 226, 1342-1344. (Pubitemid 15215592)
38. Nishida K, Ohta Y, Ishiguro I: Modulation of stress-induced gastric mucosal lesions by exogenous L-arginine. J Lab Clin Med, 1999, 133, 440-450. (Pubitemid 29212167)
39. Ohi K, Mikuni M, Takahashi K: Stress adaptation and hypersensitivity in 5-HT neuronal systems after repeated foot shock. Pharmacol Biochem Behav, 1989, 34, 603-608. (Pubitemid 20025104)
40. Olinda TM, Lemos TL, Machado LL, Rao VS, Santos FA: Quebrachitol induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels. Phytomedicine, 2008, 15, 327-333. (Pubitemid 351508393)
41. Omar ME, Salam A: Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats. Pharmacol Res, 2004, 50, 309-316.
42. Pariante C, Thomas S, Lovestone S, Makoff A, Kerwin R: Do antidepressants regulate how cortisol affects the brain? Psychoneuroendocrinology, 2004, 29, 423-447. (Pubitemid 38121601)
43. Peskar BM, Ehrlich K, Peskar BA: Role of ATP-sensitive potassium channels in prostaglandin-mediated gastroprotection in the rat. J Pharmacol Exp Ther, 2002, 301, 969-974. (Pubitemid 34595087)
44. Polat B, Albayrak Y, Suleyman B, Dursun H, Odabasoglu F, Yigiter M, Halici Z, Suleyman H: Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats. Pharmacol Rep, 2011, 63, 518-26.
45. Rainsford KD: Structure-activity relationships of nonsteroid anti-inflammatory drug gastric ulcerogenic activity. Agents Actions, 1978, 8, 587-605.
46. Ramakrishnan K, Salinas RC: Peptic ulcer disease. Am Fam Physician, 2007, 76, 1005-10012.
47. Sairam K, Rao CV, Goel RK: Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats. Indian J Exp Biol, 2001, 39, 137-142. (Pubitemid 32183936)
48. Sen T, Abdulsalam CA, Pal S, Sen S, Karmakar S, Saravanan KS, Chaudhuri AK: Effect of amitriptyline on gastric ulceration. Fundam Clin Pharmacol, 2002, 16, 311-315. (Pubitemid 35205342)
49. Sen T, Abdulsalam CA, Pal S, Sen S, Nak Chaudhuri AK: Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids. Life Sci, 2000, 66PL, 325-330.
50. Shrivastava RK, Siegal H, Lawlor R, Shah BK, Dayican G: Doxepin therapy for duodenal ulcer: a controlled trial in patients who failed to respond to cimetidine. Clin Ther, 1985, 7, 319-326. (Pubitemid 15074500)
51. Wallace JL, Granger DN: The cellular and molecular basis of gastric mucosal defense. FASEB J, 1996, 10, 731-740. (Pubitemid 26172819)
52. Wills ED: Lipid peroxide formation in microsomes. The role of non-haem iron. Biochem J, 1969b, 113, 325-332.
53. Woodward CJ, Emery PW: Determination of plasma corticosterone using high-performance liquid chromatography. J Chromatogr, 1987, 419, 280-284. (Pubitemid 17139359)
54. Yamaguchi T, Hidaka N, Suemaru K, Araki H: The coadministration of paroxetine and low-dose aspirin synergistically enhances gastric ulcerogenic risk in rats. Biol Pharm Bull, 2008, 31, 1371-1375. (Pubitemid 351930649)
55. Zahorodna A, Hess G: Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT1A and 5-HT2 receptors in rat frontal cortex. J Physiol Pharmacol, 2006, 57, 389-399. (Pubitemid 44543874)