Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats

Pharmacological Research

Volumn 50, Issue 3, 2004, Pages 309-316

  Abdel Salam, Omar M E ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Fluoxetine; Gastric acid; Sertraline; Urethane anaesthetized rat

Indexed keywords

FLUOXETINE; SERTRALINE;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH FISTULA; VAGOTOMY; VAGUS NERVE;

ANESTHESIA; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOXETINE; GASTRIC ACID; MALE; NEURAL PATHWAYS; RATS; RATS, SPRAGUE-DAWLEY; SERTRALINE; VAGUS NERVE;

EID: 3042549837     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2004.01.010     Document Type: Article

References (29)

1. Stahl S.M. Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects. J. Affect Disord. 51:1988;215-235
2. Nutt D.J., Forshall S., Bell C., Rich A., Sandford J., Nash J., et al. Mechanisms of action of selective serotonin reuptake inhibitors in the treatment of psychiatric disorders. Eur. Neuropsychopharmacol. 9(Suppl. 3):1999;S81-S86
3. Montgomery S.A. Efficacy and safety of the selective serotonin reuptake inhibitors in treating depression in elderly patients. Int. Clin. Psychopharmacol. 13(Suppl 5):1998;S49-S54
4. de Abajo F.J., Rodríguez L.A.G., Montero D. Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study. BMJ. 319:1999;1106-1109
5. Leibowitz S.F. The role of serotonin in eating disorders. Drugs. 39(Suppl. 3):1990;33-48
6. Chung K.K., Martinez M., Herbert J. Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats. Neuroscience. 92:1999;613-625
7. Mann J.J., Malone K.M., Diehl D.J., Perel J., Cooper T.B., Mintun M.A. Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am. J. Psychiatry. 153:1996;174-182
8. Dhasmana K.M., Zhu Y.N., Cruz S.L., Villalon C.M. Gastrointestinal effects of 5-hydroxytryptamine and related drugs. Life Sci. 53:1993;1651-1661
9. Fujimiya M., Okumiya K., Yamane T., Maeda T. Distribution of serotonin-immunoreactive nerve cells and fibers in the rat gastrointestinal tract. Histochem. Cell Biol. 107:1997;105-114
10. Li J.P., Chang T.M., Chey W.Y. Roles of 5-HT receptors in the release and action of secretin on pancreatic secretion in rats. Am. J. Physiol. 280:2001;G595-G602
11. Yu P.L., Fujimura M., Hayashi N., Nakamura T., Fujimiya M. Mechanisms in regulating the release of serotonin from the perfused rat stomach. Am. J. Physiol. 280:2001;G1099-G1105
12. Kitahora T., Guth P.H. Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation. Gastroenterology. 93:1987;810-817
13. Schoen R.T., Vender R.Y. Mechanisms of non-steroidal anti-inflammatory drug-induced gastric damage. Am. J. Med. 86:1989;449-458
14. Hawkey C.J., Karrasch J.A., Szczepanski L., Walker D.G., Barkun A., Swannell A.J., et al. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N. Engl. J. Med. 338:1998;727-734
15. Stephens R.L., Garrick T., Weiner H., Tache Y. Endogenous serotonin produces an inhibitory tone on vagally stimulated gastric function. Ann. N.Y. Acad. Sci. 597:1990;114-127
16. Hsu H.C., Flancbaum L.J., Kasziba E., Merrill G.F., Fisher H. Roles of in vitro- and in vivo-administered histamine and serotonin in compound 48/80-induced gastric acid secretion in isolated, perfused rat stomach. Dig. Dis. Sci. 36(12):1991;1708-1714
17. LePard K.J., Stephens R.L. Jr. Serotonin inhibits gastric acid secretion through a 5-hydroxytryptamine1-like receptor in the rat. J. Pharmacol. Exp. Ther. 270:1994;1139-1144
18. Gidener S., LePard K.J., Stephens R.L. 8-OH-DPAT stimulates gastric acid secretion through a vagal-independent, adrenal-mediated mechanism. Eur. J. Pharmacol. 284:1995;19-24
19. Lepard K.J., Chi J., Mohammed J.R., Gidener S., Stephens R.L. Jr. Gastric antisecretory effect of serotonin: quantitation of release and site of action. Am. J. Physiol. Endocrinol. Metab. 271:1996;E669-E677
20. Shockley R.A., LePard K.J., Stephens R.L. Jr. Fluoxetine pretreatment potentiates intracisternal TRH analogue-stimulated gastric acid secretion in rats. Regul. Pept. 38:1992;121-128
21. Raybould H.E., Tache Y. Capsaicin-sensitive vagal afferent fibres and stimulation of gastric acid secretion in anesthetized rats. Eur. J. Pharmacol. 167:1989;237-243
22. Fuller R.W. Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci. 55:1994;163-167
23. Piñeyro G., Blier P. Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol. Rev. 5:1999;533-591
24. Krowicki Z.K., Hornby P.J. Serotonin microinjected into the nucleus raphe obscurus increases intragastric pressure in the rat via a vagally mediated pathway. J. Pharmacol. Exp. Ther. 265:1993;468-476
25. Yoneda M., Tache Y. Serotonin enhances gastric acid response to TRH analogue in dorsal vagal complexthrough 5-HT2 receptors in rats. Am. J. Physiol. 269:1995;R1-R6
26. Varanasi S., Chi J., Stephens R.L. 5-CT or DOI augments TRH analog-induced gastric acid secretion at the dorsalvagal complex. Am. J. Physiol. 273:1997;R1607-R1611
27. Browning K.N., Travagli R.A. The peptide TRH uncovers the presence of presynaptic 5-HT1A receptors via activation of a second messenger pathway in the rat dorsal vagal complex. J. Physiol. 531:2001;425-435
28. Sevcik J., Petrovicky P., Ruzicka V., Slansky J., Masek K. Structures and pathways of the central nervous system are potentially involved in the serotonergic modulation of gastrointestinal activity. Methods Find Exp. Clin. Pharmacol. 24:2002;669-673
29. Kinney G.G., Taber M.T., Gribkoff V.K. The augmentation hypothesis for improvement of antidepressant therapy: is pindolol a suitable candidate for testing the ability of 5HT1A receptor antagonists to enhance SSRI efficacy and onset latency? Mol. Neurobiol. Mol. Neurobiol. 21:2000;137-152