Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells

British Journal of Pharmacology

Volumn 165, Issue 6, 2012, Pages 1868-1876

  Kau, Mei Mei ^a   Wang, Jiing Rong ^b   Tsai, Shiow Chwen ^c   Yu, Ching Han ^d   Wang, Paulus S ^e  

^a NATIONAL TAIPEI UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^c UNIVERSITY OF TAIPEI   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

aldosterone; bufalin; cinobufagin; cortisol; ERK; SF 1; StAR protein

Indexed keywords

8 BROMO CYCLIC AMP; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN II; BUFALIN; CINOBUFAGIN; CORTICOSTERONE; CORTODOXONE; FORSKOLIN; HYDROCORTISONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STEROID 11BETA MONOOXYGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STEROIDOGENIC FACTOR 1;

ADRENAL CORTEX CELL; ALDOSTERONE RELEASE; ARTICLE; BIOTRANSFORMATION; CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROCORTISONE RELEASE; MARKER GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STAR GENE; STEROIDOGENESIS;

ADRENAL CORTEX; ALDOSTERONE; ANGIOTENSIN II; BUFANOLIDES; BUTADIENES; CARDIOTONIC AGENTS; CELL LINE; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CORTICOSTERONE; ENZYME INHIBITORS; HUMANS; HYDROCORTISONE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRILES; PHOSPHOPROTEINS; STEROIDOGENIC FACTOR 1;

EID: 84863134813     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01671.x     Document Type: Article

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