Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells

British Journal of Pharmacology

Volumn 142, Issue 7, 2004, Pages 1123-1130

  Wang, Shyi Wu ^a   Pu, Hsaio Fung ^b   Kan, Shu Fen ^b   Tseng, Chiung I ^b   Lo, Ming Jae ^c   Wang, Paulus S ^b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Adenylyl cyclase; Corticosterone; Cyclic AMP; Digitoxin; Digoxin; Intracellular calcium; P450scc; Steroidogenesis; Zona fasciculata reticularis cells

Indexed keywords

25 HYDROXYCHOLESTEROL; 8 BROMO CYCLIC AMP; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENYLATE CYCLASE; CALCIUM; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CORTICOSTERONE; CORTICOTROPIN; CYCLIC AMP; CYCLOPIAZONIC ACID; DEOXYCORTICOSTERONE; DIGITOXIN; DIGOXIN; FORSKOLIN; OUABAIN; PREGNENOLONE; PROGESTERONE; STEROID 11BETA MONOOXYGENASE; TRILOSTANE;

ADRENAL CORTEX; ADRENAL CORTEX CELL; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HORMONE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; JUGULAR VEIN; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; STEROIDOGENESIS; ZONA FASCICULATA;

ADENYLATE CYCLASE; ANIMALS; CALCIUM; CARDIOTONIC AGENTS; CELLS, CULTURED; CORTICOSTERONE; DIGITOXIN; DIGOXIN; MALE; OUABAIN; RATS; RATS, SPRAGUE-DAWLEY; ZONA FASCICULATA; ZONA RETICULARIS;

EID: 4143054655     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705777     Document Type: Article

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