Tetrandrine cytotoxicity and its dual effect on oxidative stress-induced apoptosis through modulating cellular redox states in Neuro 2a mouse neuroblastoma cells

Life Sciences

Volumn 71, Issue 17, 2002, Pages 2053-2066

  Jin, Quanri ^a   Kang, Chulhun ^b   Soh, Yunjo ^b   Sohn, Nak Won ^b   Lee, Juhie ^a   Cho, Yong Ho ^a   Baik, Hyung Hwan ^a,b   Kang, Insug ^a,b  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University   (South Korea)

Author keywords

Apoptosis; GSH; Neuro 2a cells; p53; ROS; Tetrandrine

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; HYDROGEN PEROXIDE; PROTEIN BAX; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TETRANDRINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; MOLECULAR MECHANICS; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REGULATORY MECHANISM;

ALKALOIDS; ANIMALS; APOPTOSIS; BENZYLISOQUINOLINES; CALCIUM CHANNEL BLOCKERS; CELL FRACTIONATION; CELL SURVIVAL; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; GLUTATHIONE; IN SITU NICK-END LABELING; MICE; NEUROBLASTOMA; NEURONS; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037072670     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01989-6     Document Type: Article

References (34)

1. Stephaniae tetrandrae S. Moore
2. Tetrandrine
3. Anti-inflammatory effects of the partially purified extract of radix stephaniae tetrandrae: Comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions
4. Cytotoxicity to macrophages of tetrandrine, an antisilicosis alkaloid, accompanied by an overproduction of prostaglandins
5. Tetrandrine: A novel calcium channel antagonist inhibits type 1 calcium channels in neuroblastoma cells
6. Tetrandrine inhibits both T and L calcium channel currents in ventricular cells
7. + channels
8. 2+ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine
9. Tetrandrine as a calcium antagonist
10. Dual effects of Tetrandrine on cytosolic calcium in human leukemic HL-60 cells: Intracellular calcium release and calcium entry blockade
11. 2+ channels in vascular endothelial cells
12. 2+ antagonist: Effects and mechanisms of action in vascular smooth muscle cells
13. The role of calcium in the regulation of apoptosis
14. Status of myocardial antioxidants in ischemia-reperfusion injury
15. Cardiac effects of the extract and active components of radix Stephanie tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart
16. Tetrandrine ameliorates ischemia-reperfusion injury of rat myocardium through inhibition of neutrophil priming and activation
17. Impediment to calcium influx and reactive oxygen production accounts for the inhibition of neutrophil mac-1 up-regulation and adhesion by tetrandrine
18. Tetrandrine inhibits signal-induced NF-kB activation in rat alveolar macrophages
19. In vitro inhibition of prolieration of HL60 cells by tetrandrine and coriolus versicolor peptide derived by Chinese medical herbs
20. Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine
21. Effects of tetrandrine on growth factor-induced DNA synthesis and proliferative response of rat pulmonary artery smooth muscle cells
22. Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspases cascades and is independent of Fas/Fas ligand interaction
23. Induction of apoptosis in human leukemia U937 cells by tetrandrine
24. Enhancement of radiosensitivity in human glioblastoma U138MG cells by Tetrandrine
25. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
26. Redox regulation of cellular signaling
27. The role of glutathione in the regulation of apoptosis
28. The p53 network
29. Surfing the p53 network
30. Scavenging effect of tetrandrine of active oxygen radicals
31. Antioxidant activity of tetrandrine and its inhibition of quartz-induced lipid peroxidation
32. Altered regulation of G1 cyclins in oxidant-induced growth arrest of lung alveolar epithelial cells
33. A model for p53-induced apoptosis
34. Reactive oxygen species are downstream mediators of p53-dependent apoptosis