Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol

Drug Metabolism and Disposition

Volumn 40, Issue 3, 2012, Pages 436-444

  Tuckey, Robert C ^a   Nguyen, Minh N ^a   Chen, Jianjun ^b   Slominski, Andrzej T ^b   Baldisseri, Donna M ^c   Tieu, Elaine W ^a   Zjawiony, Jordan K ^d   Li, Wei ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c BRUKER BIOSPIN CORPORATION   (United States)

^d UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXY 22,23 EPOXY 22,23 DIHYDROERGOSTEROL; 22 KETO 22,23 DIHYDROERGOSTEROL; 22,23 EPOXYERGOSTA 5,7 DIENE 3BETA,20ALPHA DIOL; 3BETA,23 DIHYDROXYERGOSTA 5,7 DIEN 22 ONE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); EPOXIDE; ERGOSTEROL; KETOL; OXIRANOL; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROXYLATION; MASS SPECTROMETRY; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PHOSPHOLIPID BILAYER; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; STEROL ANALYSIS; STEROL METABOLISM;

CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DEHYDROCHOLESTEROLS; EPOXY COMPOUNDS; ERGOCALCIFEROLS; ERGOSTEROL; ETHYLENE OXIDE; HUMANS; HYDROXYLATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHOSPHOLIPIDS;

EID: 84863116696     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042515     Document Type: Article

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