Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl- imidazole derivatives targeting tubulin polymerization

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4782-4795

  Chen, Jianjun ^a   Li, Chien Ming ^b   Wang, Jin ^a   Ahn, Sunjoo ^b   Wang, Zhao ^a   Lu, Yan ^a   Dalton, James T ^b   Miller, Duane D ^a,b   Li, Wei ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b GTx Inc   (United States)

Author keywords

2 Aryl 4 benzoyl imidazoles; Cancer drug resistance; Melanoma; Prostate cancer

Indexed keywords

(1 BENZYL 6 CHLORO 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (1H BENZO[D]IMIDAZOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (4 FLUOROPHENYL)[2 (4 METHOXYPHENYL) 1 METHYL 1H IMIDAZOL 4 YL]METHANONE; (4 HYDROXY 3,5 DIMETHOXYPHENYL)[2 (P TOLYL) 1H IMIDAZOL 4 YL]METHANONE; (5 CHLORO 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (5 FLUORO 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (5 METHOXY 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (6 CHLORO 1 METHYL 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (6 CHLORO 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (6 FLUORO 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (6 METHOXY 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; (6 METHYL 1H INDOL 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; 2 ARYL 4 BENZOYL IMIDAZOLE DERIVATIVE; 4 SUBSTITUTED METHOXYBENZOYL ARYL THIAZOLE; [1 BENZYL 2 (P TOLYL) 1H IMIDAZOL 4 YL](4 HYDROXY 3,5 TRIMETHOXYPHENYL)METHANONE; [2 (4 BROMOPHENYL) 1H IMIDAZOL 4 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [2 (4 CHLOROPHENYL) 1H IMIDAZOL 4 YL](4 HYDROXY 3,5 DIMETHOXYPHENYL)METHANONE; [2 [4 (DIMETHYLAMINO)PHENYL] 1 [(METHOXYPHENYL)SULFONYL] 1H IMIDAZOL 4 YL](4 FLUOROPHENYL)METHANONE; [6 FLUORO 1 (PHENYLSULFONYL) 1H INDOL 2 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [6 METHOXY 1 (PHENYLSULFONYL) 1H INDOL 2 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [METHYL 2 (P TOLYL) 1H IMIDAZOL 4 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; BENZIMIDAZOLE; BENZOTHIAZOLE; COLCHICINE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER RESISTANCE; DRUG ACTIVITY; DRUG HALF LIFE; DRUG INHIBITION; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; MELANOMA; METABOLISM; NONHUMAN; POLYMERIZATION; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLES; MALE; MICE; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; POLYMERIZATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TUBULIN; TUBULIN MODULATORS;

RATTUS;

EID: 79961173585     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.084     Document Type: Article

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