In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery

Acta Pharmacologica Sinica

Volumn 33, Issue 2, 2012, Pages 279-288

  Xuan, Zhang ^a   Xing, Liu ^a   Tao, Gong ^a   Xun, Sun ^a   Zhang, Zhi Rong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

brain targeting; Dexibuprofen; ethanolamine; prodrugs

Indexed keywords

2 (4 ISOBUTYLPHENYL)PROPIONIC ACID 2 (ACETYLAMINO)ETHYL ESTER; 2 (4 ISOBUTYLPHENYL)PROPIONIC ACID 2 (N TERT BUTOXYCARBONYL N METHYLAMINO)ETHYL ESTER; 2 (4 ISOBUTYLPHENYL)PROPIONIC ACID 2 (N TERT BUTOXYCARBONYLAMINO)ETHYL ESTER; 2 (4 ISOBUTYLPHENYL)PROPIONIC ACID 2 AMINOETHYL ESTER; 2 (4 ISOBUTYLPHENYL)PROPIONIC ACID 2 DIMETHYLAMINOETHYL ESTER; 2 (4 ISOBUTYLPHENYL)PROPIONIC ACID 2 METHYLAMINOETHYL ESTER; DEXIBUPROFEN; ETHANOLAMINE; IBUPROFEN 2 DIETHYLAMINOETHYL ESTER; N ACETYL 2 AMINOETHANOL; N TERT BUTOXYCARBONYL 2 METHYLAMINOETHANOL; N TERT BUTOXYCARBONYL ETHANOLAMINE; NAPROXEN; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN; BRAIN HOMOGENATE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TISSUE LEVEL; EVALUATION; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFRARED SPECTROSCOPY; KIDNEY; LIVER; LUNG; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPLEEN;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; DRUG STABILITY; IBUPROFEN; MALE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84863116461     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.144     Document Type: Article

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