Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates

European Journal of Medicinal Chemistry

Volumn 41, Issue 11, 2006, Pages 1352-1358

  Zhao, Xiangguo ^a   Tao, Xinyi ^a   Wei, Dongzhi ^a   Song, Qingxun ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Ester; Glucopyranoside; Ibuprofen; Non steroidal anti inflammatory drugs (NSAIDs); Prodrug; Ulceration

Indexed keywords

ETHYL 6 O [2' (4' ISOBUTYLPHENYL)PROPIONYL]DEXTRO GLUCOPYRANOSIDE; GLUCOPYRANOSIDE; IBUPROFEN; IBUPROFEN DERIVATIVE; METHYL 6 O [2' (4' ISOBUTYLPHENYL)PROPIONYL]DEXTRO ALPHA GLUCOPYRANOSIDE; PRODRUG; PROPYL 6 O [2' (4' ISOBUTYLPHENYL)PROPIONYL]DEXTRO GLUCOPYRANOSIDE; UNCLASSIFIED DRUG; ANALGESIC AGENT; DRUG DERIVATIVE; GLUCOSIDE; NONSTEROID ANTIINFLAMMATORY AGENT;

ACIDITY; ALKALINITY; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOLOGY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; EDEMA; FEMALE; HYDROLYSIS; NONHUMAN; PAIN; RAT; STOMACH ULCER; ULCEROGENESIS; ANIMAL; BIOAVAILABILITY; CHEMICALLY INDUCED DISORDER; CHEMISTRY; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MASS SPECTROMETRY; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; EDEMA; FEMALE; GLUCOSIDES; IBUPROFEN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED ICR; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 33750522775     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.05.014     Document Type: Article

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