Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 6, 2012, Pages 1919-1924

  Barr, Ian ^a   Smith, Aaron T ^b   Chen, Yanqiu ^a   Senturia, Rachel ^a   Burstyn, Judith N ^b   Guo, Feng ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

DiGeorge syndrome; Ligand switching; Microprocessor; Pasha; Redox

Indexed keywords

CYSTEINE; DIGEORGE CRITICAL REGION 8; FERRIC ION; FERROUS ION; HEME; MICRORNA; NONHEME IRON PROTEIN; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CIRCULAR DICHROISM; DISSOCIATION; ELECTRONICS; IN VITRO STUDY; INTRACELLULAR MEMBRANE; PRIORITY JOURNAL; PROTEIN PROCESSING; RAMAN SPECTROMETRY; RNA BINDING;

ANIMALS; APOPROTEINS; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HEME; HUMANS; LIGANDS; MICRORNAS; MUTANT PROTEINS; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEINS;

ANIMALIA;

EID: 84863116288     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114514109     Document Type: Article

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