Activated O2 •-and H2O2mediated cell survival in SU11274-treated non-small-cell lung cancer A549 cells via c-Met-PI3K-Akt and c-Met-Grb2/SOS-Ras-p38 pathways

Journal of Pharmacological Sciences

Volumn 119, Issue 2, 2012, Pages 150-159

  Liu, Ying ^a   Shi, Qi Feng ^a   Ye, Yuan Chao ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

A549 cell; c Met; Hydrogen peroxide; SU11274; Superoxide anion

Indexed keywords

CATALASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SCATTER FACTOR RECEPTOR; SMALL INTERFERING RNA; SUPEROXIDE; SUPEROXIDE DISMUTASE; ((3Z) N (3 CHLOROPHENYL) 3 ((3,5 DIMETHYL 4 ((4 METHYLPIPERAZIN 1 YL)CARBONYL) 1H PYRROL 2 YL)METHYLENE) N METHYL 2 OXO 2,3 DIHYDRO 1H INDOLE 5 SULFONAMIDE); ((3Z)-N-(3-CHLOROPHENYL)-3-((3,5-DIMETHYL-4-((4-METHYLPIPERAZIN-1-YL)CARBONYL)-1H-PYRROL-2-YL)METHYLENE)-N-METHYL-2-OXO-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE); ANTINEOPLASTIC AGENT; GRB2 PROTEIN, HUMAN; INDOLE DERIVATIVE; PIPERAZINE DERIVATIVE; SOS PROTEIN; SULFONAMIDE;

ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CANCER INHIBITION; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; NEGATIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; METABOLISM; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CAENORHABDITIS ELEGANS; CATALASE; CELL LINE, TUMOR; CELL SURVIVAL; GRB2 ADAPTOR PROTEIN; HUMANS; HYDROGEN PEROXIDE; INDOLES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MET; RAS PROTEINS; SIGNAL TRANSDUCTION; SON OF SEVENLESS PROTEIN, DROSOPHILA; SULFONAMIDES; SUPEROXIDES;

EID: 84863109880     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12048FP     Document Type: Article

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