In vitro and in vivo effects of ketamine on generation and function of dendritic cells

Journal of Pharmacological Sciences

Volumn 117, Issue 3, 2011, Pages 170-179

  Zeng, Jingxian ^a   Xia, Shuxuan ^a   Zhong, Wa ^a   Li, Jie ^a   Lin, Liling ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Anesthesia; Conventional dendritic cell; Dendritic cell; Ketamine; Plasmacytoid dendritic cell

Indexed keywords

KETAMINE; MESSENGER RNA; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MATURATION; CELL STIMULATION; CELL SUBPOPULATION; CONTROLLED STUDY; DRUG EFFECT; ENDOCYTOSIS; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; PLASMACYTOID DENDRITIC CELL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 81455128675     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11113FP     Document Type: Article

References (49)

1. Chappell WA, White IW, Burman AL. Anaesthesia and the elderly. S Afr Med J. 1982;62:399-402. (Pubitemid 12036977)
2. Hogan BV, Peter MB, Shenoy HG, Horgan K, Hughes TA. Surgery induced immunosuppression. Surgeon. 2011;9:38-43.
3. Clements JA, Nimmo WS. Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth. 1981;53:27-30. (Pubitemid 11210925)
4. Beilin B, Rusabrov Y, Shapira Y, Roytblat L, Greemberg L, Yardeni IZ, et al. Low-dose ketamine affects immune responses in humans during the early postoperative period. Br J Anaesth. 2007;99:522-527. (Pubitemid 47412495)
5. Ohta N, Ohashi Y, Fujino Y. Ketamine inhibits maturation of bone marrow-derived dendritic cells and priming of the Th1-type immune response. Anesth Analg. 2009;109:793-800.
6. Welters ID, Hafer G, Menzebach A, Muhling J, Neuhauser C, Browning P, et al. Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines. Anesth Analg. 2010;110:934-941.
7. Lankveld DP, Bull S, Van Dijk P, Fink-Gremmels J, Hellebrekers LJ. Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line. Vet Res. 2005;36:257-262. (Pubitemid 40352603)
8. Takenaka I, Ogata M, Koga K, Matsumoto T, Shigematsu A. Ketamine suppresses endotoxin-induced tumor necrosis factor alpha production in mice. Anesthesiology. 1994;80:402-408. (Pubitemid 24064043)
9. Takahashi T, Kinoshita M, Shono S, Habu Y, Ogura T, Seki S, et al. The effect of ketamine anesthesia on the immune function of mice with postoperative septicemia. Anesth Analg. 2010;111:1051-1058.
10. Wu GJ, Chen TL, Ueng YF, Chen RM. Ketamine inhibits tumor necrosis factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation. Toxicol Appl Pharmacol. 2008;228:105-113.
11. Larsen B, Hoff G, Wilhelm W, Buchinger H, Wanner GA, Bauer M. Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology. 1998;89:1218-1227. (Pubitemid 28516547)
12. Kawasaki C, Kawasaki T, Ogata M, Nandate K, Shigematsu A. Ketamine isomers suppress superantigen-induced proinflammatory cytokine production in human whole blood. Can J Anaesth. 2001;48:819-823. (Pubitemid 33040242)
13. Melamed R, Bar-Yosef S, Shakhar G, Shakhar K, Ben-Eliyahu S. Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. Anesth Analg. 2003;97:1331-1339. (Pubitemid 37310130)
14. Chang Y, Chen TL, Sheu JR, Chen RM. Suppressive effects of ketamine on macrophage functions. Toxicol Appl Pharmacol. 2005;204:27-35. (Pubitemid 40387564)
15. Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2007;7:19-30. (Pubitemid 46020824)
16. Lipscomb MF, Masten BJ. Dendritic cells: immune regulators in health and disease. Physiol Rev. 2002;82:97-130. (Pubitemid 34654216)
17. Wilson NS, El-Sukkari D, Belz GT, Smith CM, Steptoe RJ, Heath WR, et al. Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood. 2003;102:2187-2194. (Pubitemid 37122397)
18. Naik SH, O'Keeffe M, Proietto A, Shortman HH, Wu L. CD8+, CD8-, and plasmacytoid dendritic cell generation in vitro using flt3 ligand. Methods Mol Biol. 2010;595:167-176.
19. Xu Y, Zhan Y, Lew AM, Naik SH, Kershaw MH. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J Immunol. 2007;179:7577-7584.
20. Daro E, Pulendran B, Brasel K, Teepe M, Pettit D, Lynch DH, et al. Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but not CD11b(low)CD11c(high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligand. J Immunol. 2000;165:49-58. (Pubitemid 30429489)
21. Shortman K, Heath WR. The CD8+ dendritic cell subset. Immunol Rev. 2010;234:18-31.
22. Lehtonen A, Veckman V, Nikula T, Lahesmaa R, Kinnunen L, Matikainen S, et al. Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. J Immunol. 2005;175:6570-6579. (Pubitemid 41598899)
23. Tailor P, Tamura T, Ozato K. IRF family proteins and type I interferon induction in dendritic cells. Cell Res. 2006;16:134-140. (Pubitemid 43247968)
24. Hemmi H, Akira S. TLR signalling and the function of dendritic cells. Chem Immunol Allergy. 2005;86:120-135. (Pubitemid 40905001)
25. Edwards AD, Diebold SS, Slack EM, Tomizawa H, Hemmi H, Kaisho T, et al. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol. 2003;33:827-833. (Pubitemid 36546669)
26. Naik SH, Proietto AI, Wilson NS, Dakic A, Schnorrer P, Fuchsberger M, et al. Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol. 2005;174:6592-6597. (Pubitemid 40705619)
27. Zhan Y, Xu Y, Seah S, Brady JL, Carrington EM, Cheers C, et al. Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways. J Immunol. 2010;185:2125-2133.
28. Bjorck P. Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. Blood. 2001;98:3520-3526.
29. Vremec D, Shortman K. The isolation and identification of murine dendritic cell populations from lymphoid tissues and their production in culture. Methods Mol Biol. 2008;415:163-178.
30. Clements JA, Nimmo WS, Grant IS. Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. J Pharm Sci. 1982;71:539-542. (Pubitemid 12063731)
31. Kamphorst AO, Guermonprez P, Dudziak D, Nussenzweig MC. Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol. 2010;185:3426-3435.
32. Brasel K, De Smedt T, Smith JL, Maliszewski CR. Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood. 2000;96:3029-3039.
33. Taieb A, Breitinger JJ, Unadkat JV, Shufesky WJ, Morelli AE, Thomson AW, et al. Intrinsic ability of GM+IL-4 but not Flt3L-induced rat dendritic cells to promote allogeneic T cell hyporesponsiveness. Clin Immunol. 2007;123:176-189. (Pubitemid 46590068)
34. Behrens MM, Ali SS, Dugan LL. Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. J Neurosci. 2008;28:13957-13966.
35. Sun J, Li F, Chen J, Xu J. Effect of ketamine on NF-kappa B activity and TNF-alpha production in endotoxin-treated rats. Ann Clin Lab Sci. 2004;34:181-186. (Pubitemid 38685912)
36. Wilson NS, Villadangos JA. Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm. Immunol Cell Biol. 2004;82:91-98. (Pubitemid 38388725)
37. Huang Y, Parker M, Xia C, Peng R, Wasserfall C, Clarke T, et al. Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses. J Immunol. 2009;182:4608-4615.
38. Hochrein H, O'Keeffe M, Wagner H. Human and mouse plasmacytoid dendritic cells. Hum Immunol. 2002;63:1103-1110. (Pubitemid 36025984)
39. Dallimore D, Herd DW, Short T, Anderson BJ. Dosing ketamine for pediatric procedural sedation in the emergency department. Pediatr Emerg Care. 2008;24:529-533.
40. Dallimore D, Anderson BJ, Short TG, Herd DW. Ketamine anesthesia in children-exploring infusion regimens. Paediatr Anaesth. 2008;18:708-714. (Pubitemid 352000584)
41. Atallah MM, el-Mohayman HA, el-Metwally RE. Ketamine-midazolam total intravenous anaesthesia for prolonged abdominal surgery. Eur J Anaesthesiol. 2001;18:29-35. (Pubitemid 32142692)
42. Grant IS, Nimmo WS, McNicol LR, Clements JA. Ketamine disposition in children and adults. Br J Anaesth. 1983;55:1107-1111. (Pubitemid 14244442)
43. Kadowaki N. The divergence and interplay between pDC and mDC in humans. Front Biosci. 2009;14:808-817.
44. Naik SH, Corcoran LM, Wu L. Development of murine plasmacytoid dendritic cell subsets. Immunol Cell Biol. 2005;83:563-570. (Pubitemid 41805760)
45. Honda K, Taniguchi T. Toll-like receptor signaling and IRF transcription factors. IUBMB Life. 2006;58:290-295. (Pubitemid 43880018)
46. Paun A, Pitha PM. The IRF family, revisited. Biochimie. 2007;89:744-753. (Pubitemid 47001634)
47. Tamura T, Tailor P, Yamaoka K, Kong HJ, Tsujimura H, O'Shea JJ, et al. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol. 2005;174:2573-2581. (Pubitemid 40279670)
48. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature. 2005;434:772-777. (Pubitemid 44739521)
49. Takeda K, Akira S. TLR signaling pathways. Semin Immunol. 2004;16:3-9. (Pubitemid 38147427)