Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 12, 2012, Pages 5760-5773

  Suzuki, Takayoshi ^a,b   Khan, Mohammed Naseer Ahmed ^b   Sawada, Hideyuki ^a,b   Imai, Erika ^b   Itoh, Yukihiro ^a   Yamatsuta, Katsura ^c   Tokuda, Natsuko ^c   Takeuchi, Jun ^c   Seko, Takuya ^c   Nakagawa, Hidehiko ^b   Miyata, Naoki ^b  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 BENZYLOXYPHENYLAMINO)BENZAMIDE; 2 (3 CYCLOHEXYLMETHOXYPHENYLAMINO)BENZAMIDE; 2 (3 ISOBUTOXYPHENYLAMINO)BENZAMIDE; 2 (3 N METHYL N BENZYLBENZAMIDOAMINO)BENZAMIDE; 2 (3 N METHYLBENZYLPHENYLAMINO)BENZAMIDE; 2 (4 AMINOPHENYLAMINO)BENZAMIDE; 2 [(3 PHENETHOXYPHENYL)AMINO]BENZAMIDE; 2 [3 (2 BROMOPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (2 CHLOROPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (2 FLUOROPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (2 METHYLPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (3 FLUOROPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (3 TRIFLUOROMETHYLPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (4 CHLOROPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (4 FLUOROPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (4 METHYLPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [3 (4 TRIFLUOROMETHYLPHENETHYLOXY)PHENYLAMINO]BENZAMIDE; 2 [4 (METHYLPHENYLCARBAMOYL) PHENYLAMINO]BENZOIC ACID; 3 BROMO N METHYL N PHENYLBENZAMIDE; 4 AMINO N METHYL N PHENYLBENZAMIDE; 4 BROMOSTILBENE; ALPHA TUBULIN; BENZAMIDE DERIVATIVE; HYDROLASE INHIBITOR; METHYL 2 [4 (METHYLPHENYLCARBAMOYL) PHENYLAMINO]BENZOATE; N METHYL 4 NITRO N PHENYLBENZAMIDE; PROTEIN P53; SIRTUIN 2; SIRTUIN 2 INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACETYLATION; ARTICLE; COLON CANCER; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY;

BENZAMIDES; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN CONFORMATION; SIRTUIN 2; SUBSTRATE SPECIFICITY;

EID: 84863091432     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3002108     Document Type: Article

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