Targeting the hedgehog signaling pathway with interacting peptides to Patched-1

Journal of Gastroenterology

Volumn 47, Issue 4, 2012, Pages 452-460

  Nakamura, Masafumi ^a   Tanaka, Haruo ^b   Nagayoshi, Yousuke ^a   Nakashima, Hiroshi ^a   Tsutsumi, Kosuke ^a   Ohtsuka, Takao ^b   Takahata, Shunichi ^b   Tanaka, Masao ^b   Okada, Hidechika ^c  

^a KAWASAKI MEDICAL SCHOOL   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c Research Institute for Protein Science   (Japan)

Author keywords

Pancreatic cancer; Patched 1 protein; Peptides; Signal transduction

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AMINO ACID; C PEPTIDE; PEPTIDE A; PEPTIDE B; PEPTIDE D; PEPTIDE F; PEPTIDE G; PEPTIDE H; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; SYNTHETIC PEPTIDE; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL COUNT; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN ASPC 1; CELL STRAIN SUIT2; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TARGETING; FEMALE; GENE PRODUCT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, SCID; PANCREATIC NEOPLASMS; PEPTIDES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 84863087715     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-011-0507-6     Document Type: Article

References (41)

1. Nakamura M, Wada J, Suzuki H, Tanaka M, Katano M, Morisaki T. Long-term outcome of immunotherapy for patients with refractory pancreatic cancer. Anticancer Res. 2009;29:831-6.
2. Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, et al. Adjuvant chemotherapy with gemcitabine vs. observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA. 2007;297:267-77. (Pubitemid 46143304)
3. Burris HA 3rd, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-13. (Pubitemid 27251144)
4. Nakamura M, Masuda H, Horii J, Kuma K, Yokoyama N, Ohba T, et al. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. J Cell Biol. 1998;143:1041-52. (Pubitemid 28547402)
5. Koorstra JB, Hustinx SR, Offerhaus GJ, Maitra A. Pancreatic carcinogenesis. Pancreatology. 2008;8:110-25. (Pubitemid 351670364)
6. Kameda C, Tanaka H, Yamasaki A, Nakamura M, Koga K, Sato N, et al. The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer. Anticancer Res. 2009;29:871-9.
7. Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003;425:851-6. (Pubitemid 37355945)
8. Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Beachy PA, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003;425:846-51. (Pubitemid 37351469)
9. Kubo M, Nakamura M, Tasaki A, Yamanaka N, Nakashima H, Nomura M, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res. 2004;64:6071-4. (Pubitemid 39129406)
10. Nakashima H, Nakamura M, Yamaguchi H, Yamanaka N, Akiyoshi T, Koga K, et al. Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res. 2006;66:7041-9. (Pubitemid 44197680)
11. Yanai K, Nagai S, Wada J, Yamanaka N, Nakamura M, Torata N, et al. Hedgehog signaling pathway is a possible therapeutic target for gastric cancer. J Surg Oncol. 2007;95:55-62. (Pubitemid 46122719)
12. Kameda C, Nakamura M, Tanaka H, Yamasaki A, Kubo M, Tanaka M, et al. Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ER alphapositive gastric cancer. Br J Cancer. 2010;102:738-47.
13. Nakamura M, Kubo M, Yanai K, Mikami Y, Ikebe M, Nagai S, et al. Anti-patched-1 antibodies suppress hedgehog signaling pathway and pancreatic cancer proliferation. Anticancer Res. 2007;27:3743-7. (Pubitemid 47598439)
14. Koga K, Nakamura M, Nakashima H, Akiyoshi T, KuboM, Sato N, et al. Novel link between estrogen receptor alpha and hedgehog pathway in breast cancer. Anticancer Res. 2008;28:731-40.
15. Nagai S, Nakamura M, Yanai K, Wada J, Akiyoshi T, Nakashima H, et al. Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation. Cancer Sci. 2008;99:1377-84. (Pubitemid 351761727)
16. Campbell W, Kleiman L, Barany L, Li Z, Khorchid A, Fujita E, et al. A novel genetic algorithm for designing mimetic peptides that interfere with the function of a target molecule. Microbiol Immunol. 2002;46:211-5. (Pubitemid 34289018)
17. Hosokawa M, Imai M, Okada H, Okada N. Inhibition of HIV-1 infection in cells expressing an artificial complementary peptide. Biochem Biophys Res Commun. 2004;324:236-40. (Pubitemid 39311484)
18. Shimomura Y, Kawamura T, Komura H, Campbell W, Okada N, Okada H. Modulation of procarboxypeptidase R (ProCPR) activation by complementary peptides to thrombomodulin. Microbiol Immunol. 2003;47:241-5. (Pubitemid 36362449)
19. Fujita E, Farkas I, Campbell W, Baranyi L, Okada H, Okada N. Inactivation of C5a anaphylatoxin by a peptide that is complementary to a region of C5a. J Immunol. 2004;172:6382-7. (Pubitemid 38621247)
20. Okada H, Imai M, Ono F, Okada A, Tada T, Mizue Y, et al. Novel complementary peptides to target molecules. Anticancer Res. 2011;31:2511-6.
21. Baranyi L, Campbell W, Ohshima K, Fujimoto S, Boros M, Okada H. The antisense homology box: a new motif within proteins that encodes biologically active peptides. Nat Med. 1995;1:894-901.
22. Akiyoshi T, Nakamura M, Yanai K, Nagai S, Wada J, Koga K, et al. Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells. Gastroenterology. 2008;134:131-44. (Pubitemid 350309314)
23. Nakamura M, Zhou XZ, Kishi S, Lu KP. Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett. 2002;514:193-8. (Pubitemid 34273938)
24. Lauth M, Bergstrom A, Shimokawa T, Tostar U, Jin Q, Fendrich V, et al. DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol. 2010;17:718-25.
25. Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernandez-Zapico ME, Hanahan D. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev. 2009;23:24-36.
26. Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V, et al. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci USA. 2007;104:5895-900. (Pubitemid 47175630)
27. Ji Z, Mei FC, Xie J, Cheng X. Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem. 2007;282:14048-55. (Pubitemid 47100411)
28. Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, et al. Hedgehog signaling overrides p53-mediatedtumor suppression by activating Mdm2. Proc Natl Acad Sci USA. 2008;105:4838-43. (Pubitemid 351753833)
29. Katoh Y, Katoh M. Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53. Int J Oncol. 2008;33:881-6.
30. Stecca B, Ruizi Altaba A. A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J. 2009;28:663-76.
31. Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, et al. Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch. 2001;439:798-802.
32. Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res. 2007;67:2187-96. (Pubitemid 46424238)
33. Ingham PW, Nystedt S, Nakano Y, Brown W, Stark D, van den Heuvel M, Taylor AM. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr Biol. 2000;10:1315-8.
34. Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, et al. Mapping sonic hedgehog-receptor interactions by steric interference. J Biol Chem. 2000;275:10995-1001. (Pubitemid 30212738)
35. Martin V, Carrillo G, Torroja C, Guerrero I. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. Curr Biol. 2001;11:601-7. (Pubitemid 32324763)
36. Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 1996;384:129-34. (Pubitemid 26386461)
37. Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 1996;10:301-12. (Pubitemid 26058963)
38. Olsen CL, Hsu PP, Glienke J, Rubanyi GM, Brooks AR. Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer. 2004;4:43.
39. Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP. Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas. 2008;37:440-4.
40. Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, et al. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One. 2010;5:e8824.
41. van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet. 2004;36:277-82. (Pubitemid 38282753)