RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and Modulates brown fat cell metabolism

Molecular and Cellular Biology

Volumn 32, Issue 2, 2012, Pages 266-275

  Wei, Ping ^a   Pan, Dongning ^a   Mao, Chunxiao ^a   Wang, Yong Xu ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RING FINGER PROTEIN; RING FINGER PROTEIN 34; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CARBOXY TERMINAL SEQUENCE; CELL METABOLISM; COLD EXPOSURE; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN TARGETING; SIGNAL TRANSDUCTION; THERMOGENESIS; UBIQUITINATION;

ADIPOCYTES, BROWN; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COLD TEMPERATURE; COS CELLS; ENERGY METABOLISM; F-BOX PROTEINS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; PROTEIN BINDING; TRANS-ACTIVATORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UP-REGULATION;

EID: 84863067775     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05674-11     Document Type: Article

References (34)

1. Cantó C, et al. 2009. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458:1056 -1060.
2. Cantó C, et al. 2010. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 11: 213-219.
3. Cardozo T, Pagano M. 2004. The SCF ubiquitin ligase: insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 5:739-751.
4. Christianson JL, Boutet E, Puri V, Chawla A, Czech MP. 2010. Identification of the lipid droplet targeting domain of the Cidea protein. J. Lipid Res. 51:3455-3462.
5. Cypess AM, et al. 2009. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360:1509-1517.
6. Fernandez-Marcos PJ, Auwerx J. 2011. Regulation of PGC-1{alpha}, a nodal regulator of mitochondrial biogenesis. Am. J. Clin. Nutr. 93: 884S-90S.
7. Gerhart-Hines Z, et al. 2007. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 26:1913-1923.
8. He TC, et al. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U. S. A. 95:2509-2514.
9. Jäger S, Handschin C, St. Pierre J, Spiegelman BM. 2007. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc. Natl. Acad. Sci. U. S. A. 104: 12017-12022.
10. Klein J, et al. 1999. Beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J. Biol. Chem. 274:34795-34802.
11. Lerin C, et al. 2006. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab. 3:429-438.
12. Li X, Monks B, Ge Q, Birnbaum MJ. 2007. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447:1012-1016.
13. Lin J, Handschin C, Spiegelman BM. 2005. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1:361-370.
14. Lin J, et al. 2004. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119:121-135.
15. Nedergaard J, Bengtsson T, Cannon B. 2007. Unexpected evidence for active brown adipose tissue in adult humans. Am. J. Physiol. Endocrinol. Metab. 293:E444-452.
16. Olson BL, et al. 2008. SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev. 22:252-264.
17. Onoyama I, et al. 2011. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J. Clin. Invest. 121:342-354.
18. Pan D, Fujimoto M, Lopes A, Wang YX. 2009. Twist-1 is a PPARdeltainducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137:73- 86.
19. Puigserver P, et al. 2001. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol. Cell 8:971-982.
20. Puigserver P, et al. 1998. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839.
21. Puri V, et al. 2008. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc. Natl. Acad. Sci. U. S. A. 105:7833-7838.
22. Rodgers JT, Haas W, Gygi SP, Puigserver P. 2010. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 11:23-34.
23. Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P. 2008. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 582:46 -53.
24. Rodgers JT, et al. 2005. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434:113-118.
25. Schreiber E, Matthias P, Muller MM, Schaffner W. 1989. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
26. Seale P, Lazar MA. 2009. Brown fat in humans: turning up the heat on obesity. Diabetes 58:1482-1484.
27. Shimizu T, Yokotani K. 2009. Acute cold exposure-induced downregulation of CIDEA, cell death-inducing DNA fragmentation factoralpha-like effector A, in rat interscapular brown adipose tissue by sympathetically activated beta3-adrenoreceptors. Biochem. Biophys. Res. Commun. 387:294 -299.
28. Southgate RJ, et al. 2005. PGC-1alpha gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle. FASEB J. 19:2072-2074.
29. Uldry M, et al. 2006. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 3:333-341.
30. van Marken Lichtenbelt WD, et al. 2009. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360:1500 -1508.
31. Virtanen KA, et al. 2009. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360:1518 -1525.
32. Welcker M, Clurman BE. 2008. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 8:83-93.
33. Yoon JC, et al. 2001. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-138.
34. Zhou Z, et al. 2003. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35:49 -56.