Single-walled carbon nanotubes induce airway hyperreactivity and parenchymal injury in mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 46, Issue 2, 2012, Pages 257-267

  Hsieh, Wan Yu ^a,b   Chou, Cheng Chung ^c   Ho, Chao Chi ^b   Yu, Sung Liang ^d   Chen, Hsuan Yu ^e   Chou, Han Yi E ^b   Chen, Jeremy J W ^f   Chen, Huei Wen ^b   Yang, Pan Chyr ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^d School of Medicine   (Taiwan)

^e INSTITUTE OF STATISTICAL SCIENCE   (Taiwan)

^f NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Cathepsin K; Matrix metalloproteinase 12; NF B; Single walled carbon nanotubes; Toxicity

Indexed keywords

CATHEPSIN K; CATHEPSIN K INHIBITOR; CUTANEOUS T CELL ATTRACTING CHEMOKINE; MACROPHAGE ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PENTOXIFYLLINE; PYRROLIDINE DITHIOCARBAMATE; SINGLE WALLED NANOTUBE; TOLL LIKE RECEPTOR 2;

AIRWAY HYPERREACTIVITY; AIRWAY INFLAMMATION; AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; GENE EXPRESSION; IN VIVO STUDY; INFLAMMATION; LUNG DISEASE; LUNG INJURY; MACROPHAGE; MALE; MESENCHYME CELL; MOUSE; NONHUMAN; OBSTRUCTIVE AIRWAY DISEASE; UPREGULATION;

ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; COCULTURE TECHNIQUES; GENE EXPRESSION PROFILING; LUNG; MALE; MICE; MICE, INBRED ICR; NANOTUBES, CARBON; TRANSCRIPTOME; UP-REGULATION;

MUS;

EID: 84863036594     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0010OC     Document Type: Article

References (50)

1. Minchin R. Nanomedicine: sizing up targets with nanoparticles. Nat Nanotechnol 2008;3:12-13.
2. Scheringer M. Nanoecotoxicology: environmental risks of nanomaterials. Nat Nanotechnol 2008;3:322-323. (Pubitemid 351809618)
3. Kipen HM, Laskin DL. Smaller is not always better: nanotechnology yields nanotoxicology. Am J Physiol Lung Cell Mol Physiol 2005;289: L696-L697. (Pubitemid 41504398)
4. Chen HW, Su SF, Chien CT, Lin WH, Yu SL, Chou CC, Chen JJ, Yang PC. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. FASEB J 2006;20:2393-2395.
5. Zhao YXG, Chai Z. Nanotoxicology: are carbon nanotubes safe? Nat Nanotechnol 2008;3:191-192. (Pubitemid 351499406)
6. Lam CW, James JT, McCluskey R, Hunter RL. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 2004;77:126-134. (Pubitemid 38128652)
7. Chou CC, Hsiao HY, Hong QS, Chen CH, Peng YW, Chen HW, Yang PC. Single-walled carbon nanotubes can induce pulmonary injury in mouse model. Nano Lett 2008;8:437-445. (Pubitemid 351345996)
8. Schipper ML, Nakayama-Ratchford N, Davis CR, Kam NW, Chu P, Liu Z, Sun X, Dai H, Gambhir SS. A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. Nat Nanotechnol 2008;3: 216-221. (Pubitemid 351506336)
9. Inoue KI, Koike E, Yanagisawa R, Hirano S, Nishikawa M, Takano H. Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol Appl Pharmacol 2009;237:306-316.
10. Sakamoto Y, Nakae D, Fukumori N, Tayama K, Maekawa A, Imai K, Hirose A, Nishimura T, Ohashi N, Ogata A. Induction of mesothelioma by a single intra-scrotal administration of multi-wall carbon nanotube in intact male fischer 344 rats. J Toxicol Sci 2009;34:65-76.
11. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, Stone V, Brown S, Macnee W, Donaldson K. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 2008;3:423-428.
12. Shvedova AA, Kisin ER, Murray AR, Johnson VJ, Gorelik O, Arepalli S, Hubbs AF, Mercer RR, Keohavong P, Sussman N, et al. Inhalation vs. aspiration of single carbone nanotubes in c57bl/6 mice: Inflammation, fibrosis, oxidative stress and mutagenesis. Am J Physiol Lung Cell Mol Physiol 2008;295:L552-L565.
13. Sharma CS, Sarkar S, Periyakaruppan A, Barr J, Wise K, Thomas R, Wilson BL, Ramesh GT. Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells. J Nanosci Nanotechnol 2007;7:2466-2472.
14. Kisin ER, Murray AR, Keane MJ, Shi XC, Schwegler-Berry D, Gorelik O, Arepalli S, Castranova V, Wallace WE, Kagan VE, et al. Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast v79 cells. J Toxicol Environ Health A 2007;70:2071-2079. (Pubitemid 350207578)
15. Manna SK, Sarkar S, Barr J, Wise K, Barrera EV, Jejelowo O, Rice-Ficht AC, Ramesh GT. Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappa b in human keratinocytes. Nano Lett 2005;5:1676-1684. (Pubitemid 41396145)
16. Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 2008;118:3546-3556.
17. Chang YR, Lee HY, Chen K, Chang CC, Tsai DS, Fu CC, Lim TS, Tzeng YK, Fang CY, Han CC, et al. Mass production and dynamic imaging of fluorescent nanodiamonds. Nat Nanotechnol 2008;3:284-288. (Pubitemid 351668061)
18. Liu CC, Lin CC, Chen WS, Chen HY, Chang PC, Chen JJ, Yang PC. Crsd: a comprehensive web server for composite regulatory signature discovery. Nucleic Acids Res 2006;34:W571-W577. (Pubitemid 44529834)
19. Warshamana GS, Corti M, Brody AR. TNF-alpha, PDGF, and Tgf-beta (1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells: TNF-alpha induces TGF-beta(1). Exp Mol Pathol 2001;71:13-33. (Pubitemid 32802855)
20. Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 2006;177:7303-7311. (Pubitemid 44715100)
21. Jia G, Wang H, Yan L, Wang X, Pei R, Yan T, Zhao Y, Guo X. Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene. Environ Sci Technol 2005;39:1378-1383. (Pubitemid 40333400)
22. Fujita K, Morimoto Y, Ogami A, Myojyo T, Tanaka I, Shimada M, Wang WN, Endoh S, Uchida K, Nakazato T, et al. Gene expression profiles in rat lung after inhalation exposure to c60 fullerene particles. Toxicology 2009;258:47-55.
23. Liu KK, Cheng CL, Chang CC, Chao JI. Biocompatible and detectable carboxylated nanodiamond on human cell. Nanotechnology 2007;18: 325102.
24. Zhang X, Yin J, Kang C, Li J, Zhu Y, Li W, Huang Q, Zhu Z. Biodistribution and toxicity of nanodiamonds in mice after intratracheal instillation. Toxicol Lett 2010;198:237-243.
25. Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF,Wong BA, Bonner JC. Inhaled multi-walled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. Am J Respir Cell Mol Biol 2009;40: 349-358.
26. Barnes PJ. Mechanisms in COPD: differences from asthma. Chest 2000; 117:10S-14S. (Pubitemid 30111557)
27. Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, Tyurina YY, Gorelik O, Arepalli S, Schwegler-Berry D, et al. Unusual inflammatory and fibrogenic pulmonary responses to singlewalled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005;289:L698-L708. (Pubitemid 41504399)
28. Gorska K, Krenke R, Korczynski P, Kosciuch J, Domagala-Kulawik J, Chazan R. Eosinophilic airway inflammation in chronic obstructive pulmonary disease and asthma. J Physiol Pharmacol 2008;59:261-270.
29. Samokhin AO, Gauthier JY, Percival MD, Brömme D. Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis. Respir Res 2011;12:13.
30. Lagente V, Le Quement C, Boichot E. Macrophage metallo-elastase (MMP-12) as a target for inflammatory respiratory diseases. Expert Opin Ther Targets 2009;13:287-295.
31. Huizar I, Malur A, Midgette YA, Kukoly C, Chen P, Ke PC, Podila R, Rao AM, Wingard CJ, Dobbs L, Barna BP, Kavuru MS, Thomassen MJ. Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes. Am J Respir Cell Mol Biol 2011;45: 858-866.
32. Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008;454:445-454.
33. Lemaire I. Selective differences in macrophage populations and monokine production in resolving pulmonary granuloma and fibrosis. Am J Pathol 1991;138:487-495.
34. Page-McCaw A, Andrew J, Werb EZ. Matrix metalloproteinases and the regulation of tissue remodeling. Nat Rev Mol Cell Biol 2007;8:221-233.
35. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, et al. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 2004; 101:14895-14900. (Pubitemid 39410771)
36. Abboud RT, Vimalanathan S. Pathogenesis of COPD: part i. The role of protease-anti-protease imbalance in emphysema. Int J Tuberc Lung Dis 2008;12:361-367. (Pubitemid 351507246)
37. Merrilees MJ, Hankin EJ, Black JL, Beaumont B. Matrix proteoglycans and remodeling of interstitial lung tissue in lymphangioleiomyomatosis. J Pathol 2004;203:653-660. (Pubitemid 38714102)
38. Nénan SPJ, Berna P, De Mendez I, Hitier S, Shapiro SD, Boichot E, Lagente V, Bertrand CP. Analysis of the inflammatory response induced by rhmmp-12 catalytic domain instilled in mouse airways. Int Immunopharmacol 2005;5:511-524. (Pubitemid 40430759)
39. Molet S, Belleguic C, Lena H, Germain N, Bertrand CP, Shapiro SD, Planquois JM, Delaval P, Lagente V. Increase in macrophage elastase (mmp-12) in lungs from patients with chronic obstructive pulmonary disease. Inflamm Res 2005;54:31-36. (Pubitemid 40385338)
40. Bühling F, Reisenauer A, Gerber A, Krüger S, Weber E, Brömme D, Roessner A, Ansorge S, Welte T, Röcken C. Cathepsin k: a marker of macrophage differentiation? J Pathol 2001;195:375-382.
41. Coimbra R, Melbostad H, Loomis W, Porcides RD, Wolf P, Tobar M, Hoyt DB. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on pro-inflammatory mediators, metalloproteinases, nf-kappa b, and icam-1 expression. J Trauma 2006;60:115-125.
42. Eren GCZ, Hergunsel O, Demir G, Kucur M, Uslu E, Dalo E, Uhri M, Tugcu V. Protective effect of the nuclear factor kappa b inhibitor pyrrolidine dithiocarbamate in lung injury in rats with streptozotocin-induced diabetes. Respiration 2010;79:402-410.
43. Kabay B, Teke Z, Aytekin FO, Yenisey C, Bir F, Sacar M, Erdem E, Ozden A. Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model. World J Surg 2007;31:1707-1715. (Pubitemid 47063429)
44. Kobayashi N, Naya M, Ema M, Endoh S, Maru J, Mizuno K, Nakanishi J. Biological response and morphological assessment of individually dispersed multi-wall carbon nanotubes in the lungs after intratracheal instillation in rats. Toxicology 2010;276:143-153.
45. Inoue K, Yanagisawa R, Koike E, Nishikawa M, Takano H. Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: possible role of oxidative stress. Free Radic Biol Med 2010;48:924-934.
46. Morimoto Y, Hirohashi M, Ogami A, Oyabu T, Myojo T, Todoroki M, Yamamoto M, Hashiba M, Mizuguchi Y, Lee BW, et al. Pulmonary toxicity of well-dispersed multi-wall carbon nanotubes following inhalation and intra-tracheal instillation. Nanotoxicology (In press)
47. Bonner JC. Nanoparticles as a potential cause of pleural and interstitial lung disease. Proc Am Thorac Soc 2010;7:138-141.
48. Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Aschberger K, Stone V. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: the contribution of physico-chemical characteristics. Nanotoxicology 2010;4:207-246.
49. Ryman-Rasmussen JP, Cesta MF, Brody AR, Shipley-Phillips JK, Everitt JI, Tewksbury EW, Moss OR, Wong BA, Dodd DE, Andersen ME, et al. Inhaled carbon nanotubes reach the sub-pleural tissue in mice. Nat Nanotechnol 2009;4:745-751.
50. Mitchell LA, Gao J, Wal RV, Gigliotti A, Burchiel SW, McDonald JD. Pulmonary and systemic immune response to inhaled multi-walled carbon nanotubes. Toxicol Sci 2007;100:203-214. (Pubitemid 47617817)