Inhibition of osteoclast differentiation and bone resorption by tanshinone IIA isolated from Salvia miltiorrhiza Bunge

Biochemical Pharmacology

Volumn 67, Issue 9, 2004, Pages 1647-1656

  Kim, Hong Hee ^a,b   Kim, Jung Ha ^a,c   Kwak, Han Bok ^a,c   Huang, Hao ^b   Han, Song Hee ^a   Ha, Hyunil ^a,c   Lee, Soo Woong ^a,c   Woo, Eun Ran ^a   Lee, Zang Hee ^a,c,d  

^a Chosun University   (South Korea)

^b Seoul National University   (South Korea)

^c Natl Res Lab for Bone Metabolism   (South Korea)

^d Chosun University   (South Korea)

Author keywords

ERK; Extracellular signal regulated kinase; M CSF; Macrophage colony stimulating factor; NF B; Nuclear factor kappa B; Osteoclast; RANKL; Receptor activator of nuclear factor kappa B ligand; Tanshinone IIA; Tartrate resistant acid phosphatase; TRAP

Indexed keywords

ACTIN; BETA3 INTEGRIN; CALCITONIN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE;

ANIMAL CELL; ARTICLE; BONE MARROW CULTURE; CELL DIFFERENTIATION; CELL FUSION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION; STEM CELL; UPREGULATION;

ACTINS; ANIMALS; BONE MARROW CELLS; BONE RESORPTION; CELL DIFFERENTIATION; CELL FUSION; CELLS, CULTURED; GENE EXPRESSION; GLYCOPROTEINS; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OSTEOCLASTS; OSTEOPROTEGERIN; PHENANTHRENES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; SALVIA MILTIORRHIZA; SIGNAL TRANSDUCTION;

EID: 1842634583     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.12.031     Document Type: Article

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