Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

Neural Regeneration Research

Volumn 7, Issue 3, 2012, Pages 197-201

  Chen, Zhihong ^a   He, Yaqiang ^a   Song, Chengjun ^a   Dong, Zhijun ^a   Su, Zhejun ^a   Xue, Jingfeng ^a  

^a CHENGDE MEDICAL COLLEGE   (China)

Author keywords

Akt signal transduction pathway; Apoptosis; Hippocampus; Neural regeneration; Sericin; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; SERICIN;

AKT GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BCL 2 ASSOCIATED DEATH PROMOTER GENE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; INTRACELLULAR SIGNALING; MALE; NERVE CELL LESION; NEUROMODULATION; NEUROPROTECTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR FACTOR KAPPA B GENE; RAT; STREPTOZOCIN DIABETES;

EID: 84863034494     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2012.03.007     Document Type: Article

References (31)

1. Li SZ. Compendium of Materia Medica. Beijing: People's Medical Pubishing House. 1985:1045-1052.
2. Zhaorigetu S, Yanaka N, Sasaki M, et al. Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hairless mouse. J Photochem Photobiol B. 2003;71(1-3):11-17.
3. Dash R, Acharya C, Bindu PC, et al. Antioxidant potential of silk protein sericin against hydrogen peroxide-induced oxidative stress in skin fibroblasts. BMB Rep. 2008;41(3):236-241.
4. Chen ZH, Song CJ, Du XM, et al. Effects of sericin pretreatment on the expression of ECM associated protein in the kidney of diabetic nephropathy rats. Zhongguo Yike Daxue Xuebao. 2010; 39(2):112-115.
5. Fu XM, Ma HW, Fu WL, et al. Protective effects of sericin on pancreatic islet cells of type II diabetic rat. Jiepou Xue Zazhi. 2010;33(2):161-164.
6. Fu WL, Fu XY, Zhong MR, et al. Effects of sericine on growth hormone/insulin-like growth factor-1 axis of testis in type 2 diabetes mellitus rats. Jiepou Xuebao. 2011;42(1):104-109.
7. Chen ZH, He YQ, Fu WL, et al. Effects of sericin on heme oxygenase-1 expression in the hippocampus and cerebral cortex of type 2 diabetes mellitus rats. Neural Regen Res. 2011;6(6): 423-427.
8. Huang HJ, Liang KC, Chen CP, et al. Intrahippocampal administration of A beta(1-40) impairs spatial learning and memory in hyperglycemic mice. Neurobiol Learn Mem. 2007; 87(4):483-494.
9. Mijnhout GS, Scheltens P, Diamant M, et al. Diabetic encephalopathy: A concept in need of a definition. Diabetologia. 2006;49(6):1447-1448.
10. Zhang DM, Xiao Q, Zhang Y. Effects of angiotensin IV on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats. Chongqing Yike Daxue Xuebao. 2010;35(7): 978-981.
11. Prasad S, Madan E, Nigam N, et al. Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkappaB signaling pathways. Cancer Biol Ther. 2009;8(17):1632-1639.
12. Yi T, Lee HL, Cha JH, et al. Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling. J Cell Physiol. 2008;217(2):409-422.
13. Guo H. The effect of Taxol on the PI3K/Akt signaling pathway and its sensitizing effect of LY294002. Shanghai: Shanghai Jiao Tong University. 2009.
14. Xiao GH, Wang ZB. The regulation effect of PKB/Akt in the diabetes and vascular complications of diabetes. Yixue Yanjiu Zazhi. 2010;39(1):13-16.
15. Huang TT, Kudo N, Yoshida M, et al. A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. Proc Natl Acad Sci U S A. 2000;97(3):1014-1019.
16. Sarnico I, Lanzillotta A, Benarese M, et al. NF-kappaB dimers in the regulation of neuronal survival. Int Rev Neurobiol. 2009;85: 351-362.
17. Li SY, Sun WG, Jia YH, et al. Calcium signal-initiated early activation of NF-kappaB in neurons is a neuroprotective event in response to kainic acid-induced excitotoxicity. Biochemistry (Mosc). 2010;75(1):101-109.
18. Yang J. Molecular modeling of human BAD, a pro-apoptotic Bcl-2 family member, integrating glycolysis and apoptosis. Protein Pept Lett. 2010;17(2):206-220.
19. Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91(2):231-241.
20. Jin Y, Yan EZ, Fan Y, et al. Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus. Acta Pharmacol Sin. 2005;26(8):943-951.
21. Kobayashi T, Taguchi K, Yasuhiro T, et al. Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model. Hypertension. 2004;44(6):956-962.
22. Mayer CM, Belsham DD. Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology. 2010;151(2):576-585.
23. Dłuzniewska J, Beresewicz M, Wojewódzka U, et al. Transient cerebral ischemia induces delayed proapoptotic Bad translocation to mitochondria in CA1 sector of hippocampus. Brain Res Mol Brain Res. 2005;133(2):274-280.
24. Miyawaki T, Mashiko T, Ofengeim D, et al. Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Proc Natl Acad Sci U S A. 2008;105(12): 4892-4897.
25. The Ministry of Science and Technology of the People's Republic of China. Guidance Suggestions for the Care and Use of Laboratory Animals. 2006-09-30.
26. Xiang X, Wang Z, Zhu Y, et al. Dosage of streptozocin in inducing rat model of type 2 diabetes mellitus. Wei Sheng Yan Jiu. 2010; 39(2):138-142.
27. Zhan YL, Huang CF, Chen GL. Hypoglycemic activity of the decoction of cocoon shell on alloxan-diabetic model mice. Canye Kexue. 2003;29(4):446-448.
28. th ed. London: Academic Press. 2005.
29. Pekcetin C, Kiray M, Ergur BU, et al. Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats. Acta Biol Hung. 2009;60(2):137-148.
30. Lu M, Xu L, Li B, et al. Protective effects of grape seed proanthocyanidin extracts on cerebral cortex of streptozotocin-induced diabetic rats through modulating AGEs/RAGE/NF-kappaB pathway. J Nutr Sci Vitaminol (Tokyo). 2010;56(2):87-97.
31. Zhan LB, Sui H, Lu XG, et al. Effects of Zibu Piyin recipe on SNK-SPAR pathway in neuron injury induced by glutamate. Chin J Integr Med. 2008;14(2):117-122.