Effects of Zibu Piyin Recipe on SNK-SPAR pathway in neuron injury induced by glutamate

Chinese Journal of Integrative Medicine

Volumn 14, Issue 2, 2008, Pages 117-122

  Zhan, Li Bin ^a   Sui, Hua ^a   Lu, Xiao Guang ^b   Sun, Chang Kai ^a   Zhang, Jian ^a   Ma, Hui ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Dendritic spine; Excitotoxicity; Serum inducible kinase; Spine associated rap GTPase activating protein; Zibu piyin recipe

Indexed keywords

BETA ACTIN; CHINESE DRUG; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POLO LIKE KINASE 2; POSTSYNAPTIC DENSITY PROTEIN 95; SPINE ASSOCIATED RAP GTPASE ACTIVATING PROTEIN; ZIBU PIYIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC SPINE; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENE INDUCTION; HIPPOCAMPUS; MALE; NERVE CELL LESION; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELLS, CULTURED; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION; GLUTAMIC ACID; GTPASE-ACTIVATING PROTEINS; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; NEURONS; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERUM;

EID: 46749117240     PISSN: 16720415     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11655-008-0117-1     Document Type: Article

References (15)

1. Gazulla J, Cavero-Nagore M. Glutamate and Alzheimer's disease. Rev Neurol 2006;42:427-432.
2. Zhan LB, LU XG, Sun CK, et al. Anti-excitotoxicity effects of Zi-Bu-Pi-Yin Recipe in vitro and mechanisms. Acta Pharmacol Sin 2006;Suppl:352.
3. Itzstein C, Cheynel H, Burt-Pichat B, et al. Molecular identification of NMDA glutamate receptors expressed in bone cells. J Cell Biochem 2001;82:134-144.
4. Lai SK, Wong CK, Yang MS, et al. Changes in expression of N-methyl-D-aspartate receptor subunits in the rat neostriatum after a single dose of antisense oligonucleotide specific for N-methyl-D-aspartate receptor 1 subunit. Neuroscience 2000;98:493-500.
5. Zhan LB, Diao FS, Zhang LQ, et al. Effect of the Prescription nourishing the Pi-yin (PNPY) on the brain mitochondrial membrane metabolization phospholipid metabolism of senile rats. Asian Med (Chin) 1999;10(12):31-32.
6. Zhan LB, Xu F, Dong YK, et al. Effect of the Prescription Nurishing the Pi-yin (PNPY) on the brain mitochondrial membrane ATPase activity of senile rats. Pharmacol Clin Chin Materia Medica (Chin) 2000; 16 (1):24-25.
7. Zhan L, Qu MY. Effects of nourishing Piyin Remedy on learning and memory of aged rat. Pharmacol Clin Chin Materia Medica (Chin) 2002;8(6):32-35.
8. Bossy-Wetzel E, Schwarzenbache R, Lipton SA. Molecular pathways to neurodegeneration. Nat Med 2004;10 (Suppl): S2-S9.
9. Lipton SA, Rosenberg RA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994;330:613-622.
10. Meyer G, Brose N. SPARring with spines. Neuroscience 2003;302:1341-1344.
11. Pak DT, Yang S, Rudolph-Correia S, et al. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 2001;31:289-303.
12. Pak DT, Sheng M. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 2003;302:1368-1373.
13. Seeburg DP, Pak D, Sheng M. Polo-like kinases in the nervous system. Oncogene 2005;24:292-298.
14. Kauselmann G, Weiler M, Wulff P, et al. The polo-like protein kinases Fnk and SNK associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. EMBO J 1999;18:5528-5539.
15. Sans N, Petralia RS, Wang YX, et al. A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci 2000;20:1260-1271.