Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats

Acta Biologica Hungarica

Volumn 60, Issue 2, 2009, Pages 137-148

  Pekcetin, C ^a   Kiray, Muge ^a   Ergur, B U ^a   Tugyan, K ^a   Bagriyanik, H A ^a   Erbil, G ^a   Baykara, Basak ^a   Camsari, U M ^a  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Carnosine; Ischemia reperfusion; Oxidative stress; Spatial memory

Indexed keywords

CARNOSINE; GLUTATHIONE PEROXIDASE; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL DAMAGE; COMMON CAROTID ARTERY; CONTROLLED STUDY; DEPTH PERCEPTION; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HIPPOCAMPUS; LIPID PEROXIDATION; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PREFRONTAL CORTEX; RAT; REPERFUSION; SINGLE DRUG DOSE; SPATIAL MEMORY; SPECTROPHOTOMETRY; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; APOPTOSIS; BRAIN; CARNOSINE; FEMALE; IN SITU NICK-END LABELING; ISCHEMIA; ISCHEMIC ATTACK, TRANSIENT; MAZE LEARNING; NEURONS; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; TIME FACTORS;

RATTUS;

EID: 69249103779     PISSN: 02365383     EISSN: 1588256X     Source Type: Journal    
DOI: 10.1556/ABiol.60.2009.2.1     Document Type: Article

References (26)

1. Amemiya, S., Kamiya, T., Nito, C., Inaba, T., Kato, K., Ueda, M., Shimazaki, K., Katayama, Y. (2005) Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur. J. Pharmacol. 516, 125-130.
2. Block, F., Schwarz, M. (1997) Correlation between hippocampal neuronal damage and spatial learning deficit due to global ischemia. Pharmacol. Biochem. Behav. 56, 755-761.
3. Boldyrev, A., Bulygina, E., Leinsoo, T., Petrushanko, I., Tsubone, S., Abe, H. (2004) Protection of neuronal cells against reactive oxygen species by carnosine and related compounds. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 137, 81-88.
4. Boldyrev, A., Song, R., Lawrence, D., Carpenter, D. O. (1999) Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species. Neurosci. 94, 571-577.
5. Boldyrev, A. A., Stvolinsky, S. L., Tyulina, O. V., Koshelev, V. B., Hori, N., Carpenter, D. O. (1997) Biochemical and physiological evidence that carnosine is an endogenous neuroprotector against free radicals. Cell Mol. Neurobiol. 17, 259-271.
6. Cain, D. P., Boon, F. (2003) Detailed behavioral analysis reveals both task strategies and spatial memory impairments in rats given bilateral middle cerebral artery stroke. Brain Res. 972, 64-74.
7. Candelario-Jalil, E., Mhadu, N. H., Al-Dalain, S. M., Martinez, G., Leon, O. S. (2001) Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci. Res. 41, 233-241.
8. Carrillo, M. C., Kanai, S., Nokubo, M., Kitani, K. (1991) (-)Deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats. Life Sci. 48, 517-521.
9. Chan, P. H. (2001) Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21, 2-14.
10. Dobrota, D., Fedorova, T., Stvolinsky, S., Babusikova, E., Likavcanova, K., Drgova, A., Strapkova, A., Boldyrev, A. (2005) Carnosine protects the brain of rats and mongolian gerbils against ischemic injury: after-stroke-effect. Neurochem. Res. 30, 1283-1288.
11. Floyd, R. A., Hensley, K. (2002) Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 23, 795-807.
12. Gallant, S., Kukley, M., Stvolinsky, S., Bulygina, E., Boldyrev, A. (2000) Effect of carnosine on rats under experimental brain ischemia. Tohoku J. Exp. Med. 191, 85-99.
13. Homi, H. M., Freitas, J. J., Curi, R., Velasco, I. T., Junior, B. A. (2002) Changes in superoxide dismutase and catalase activities of rat brain regions during early global transient ischemia/reperfusion. Neurosci. Lett. 333, 37-40.
14. Hotta, H., Uchida, S., Kagitani, F. (2002) Effects of stimulating the nucleus basalis of Meynert on blood flow and delayed neuronal death following transient ischemia in the rat cerebral cortex. Jpn. J. Physiol. 52, 383-393.
15. Jang, M. H., Shin, M. C., Lee, T. H., Lim, B. V., Shin, M. S., Min, B. I., Kim, H., Cho, S., Kim, E. H., Kim, C. J. (2003) Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. Neurosci. Lett. 347, 5-8.
16. Jin, K., Graham, S. H., Mao, X., Nagayama, T., Simon, R. P., Greenberg, D. A. (2001) Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia. J. Cereb. Blood Flow Metab. 21, 1411-1421.
17. Kiray, M., Bagriyanik, H. A., Pekcetin, C., Ergur, B. U., Uysal, N. (2008) Protective effects of deprenyl in transient cerebral ischemia in rats. Chin. J. Physiol. 51, 1-7.
18. Klebanov, G. I., Teselkin, Y. O., Babenkova, I.V., Lyubitsky, O.B., Rebrova, O. Y., Boldyrev, A. A., Vladimirov, Y. A. (1998) Effect of carnosine and its components on free-radical reactions. Membr. Cell Biol. 12, 89-99.
19. Leutner, S., Eckert, A., Muller, W. E. (2001) ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain. J. Neural. Transm. 108, 955-967.
20. Li, Y., Chopp, M., Powers, C., Jiang, N. (1997) Apoptosis and protein expression after focal cerebral ischemia in rat. Brain Res. 765, 301-312.
21. Rehncrona, S., Smith, D. S., Akesson, B., Westerberg, E., Siesjo, B. K. (1980) Peroxidative changes in brain cortical fatty acids and phospholipids, as characterized during Fe2+ and ascorbic acid-stimulated lipid peroxidation in vitro. J. Neurochem. 34, 1630-1638.
22. Stvolinskii, S. L., Fedorova, T. N., Yuneva, M. O., Boldyrev, A. A. (2003) Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo. Bull. Exp. Biol. Med. 135, 130-132.
23. Stvolinsky, S. L., Dobrota, D. (2000) Anti-ischemic activity of carnosine. Biochemistry (Mosc). 65, 849-855.
24. Stvolinsky, S. L., Kukley, M. L., Dobrota, D., Matejovicova, M., Tkac, I., Boldyrev, A. A. (1999) Carnosine: an endogenous neuroprotector in the ischemic brain. Cell Mol. Neurobiol. 19, 45-56.
25. Tabakman, R., Jiang, H., Levine, R. A., Kohen, R., Lazarovici, P. (2004) Apoptotic characteristics of cell death and the neuroprotective effect of homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. J. Neurosci. Res. 75, 499-507.
26. Zhang, Y., Herman, B. (2002) Ageing and apoptosis. Mech. Ageing Dev. 123, 245-260.