Anti-tumor effects of Astragalus on hepatocellular carcinoma in vivo

Indian Journal of Pharmacology

Volumn 44, Issue 1, 2012, Pages 78-81

  Li, Lian Kun ^a   Kuang, Wen Juan ^b   Huang, Yun Feng ^a   Xie, Han Hong ^a   Chen, Guo ^a   Zhou, Qing Chun ^a   Wang, Bin Rong ^a   Wan, Li Hong ^b  

^a Sichuan General Hospital of Armed Police Force   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Antitumor effects; apoptosis; Astragalus; H22

Indexed keywords

ASTRAGALUS EXTRACT; CYCLOPHOSPHAMIDE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTRAGALUS PLANT; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FLOW CYTOMETRY; GROWTH CURVE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TREATMENT RESPONSE;

EID: 84863029311     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.91872     Document Type: Article

References (20)

1. Shariff MI, Cox IJ, Gomaa AI, Khan SA, Gedroyc W, Taylor-Robinson SD. Hepatocellular carcinoma: Current trends in worldwide epidemiology, risk factors, diagnosis and therapeutics. Expert Rev Gastroenterol Hepatol 2009;3:353-67.
2. Lin DY, Lin SM, Liaw YF. Non-surgical treatment of hepatocellular carcinoma. J Gastroenterol Hepatol 1997;12:S319-28.
3. Zee-Cheng RK. Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs. Methods Find Exp Clin Pharmacol 1992;14:725-36. (Pubitemid 23057193)
4. Zhang RP, Zhang XP, Ruan YF, Ye SY, Zhao HC, Cheng QH, et al. Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism. World J Gastroenterol 2009;15:2862-9.
5. Cui R, He J, Wang B, Zhang F, Chen G, Yin S, et al. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemother Pharmacol 2003;51:75-80. (Pubitemid 36057026)
6. Tin MM, Cho CH, Chan K, James AE, Ko JK. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumour xenograft. Carcinogenesis 2007;28:1347-55. (Pubitemid 47062696)
7. Prasad SB, Rosangkima G, Nicol BM. Cyclophosphamide and ascorbic acid-mediated ultrastructural and biochemical changes in Dalton's lymphoma cells in vivo. Eur J Pharmacol 2010;645:47-54.
8. Ji DB, Ye J, Jiang YM, Qian BW. Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice. BMC Complement Altern Med 2009;9:20.
9. Green DR, Evan GI.A matter of life and death. Cancer Cell 2002;1:19-30. (Pubitemid 41039172)
10. Macha MA, Matta A, Sriram U, Thakkar A, Shukla NK, Datta Gupta S, et al. Clinical significance of TC21 overexpression in oral cancer. J Oral Pathol Med 2010;39:477-85.
11. Kuhar M, Sen S, Singh N. Role of mitochondria in quercetin-enhanced chemotherapeutic response in human non-small cell lung carcinoma H-520 cells. Anticancer Res 2006;26:1297-303.
12. Song Y, Yang J, Bai WL, Ji WY. Anti-tumour and immunoregulatory effects of Astragalus on nasopharyngeal carcinoma In Vivo and In Vitro. Phytother Res 2011;25:909-15.
13. Auyeung KK, Mok NL, Wong CM, Cho CH, Ko JK. Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. Int J Mol Med 2010;26:341-9.
14. Hu YW, Liu CY, Du CM, Zhang J, Wu WQ, Gu ZL. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by flavonoids from Astragalus complanatus. J Ethnopharmacol 2009;123:293-301.
15. Auyeung KK, Law PC, Ko JK. Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. Int J Mol Med 2009;3:189-96.
16. Kim KW, Moretti L, Mitchell LR, Jung DK, Lu B. Combined Bcl-2/mammalian target of rapamycin inhibition leads to enhanced radiosensitization via induction of apoptosis and autophagy in non-small cell lung tumor xenograft model. Clin Cancer Res 2009;15:6096-105.
17. Snyder CM, Shroff EH, Liu J, Chandel NS. Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members. PLoS One 2009;4:e7059.
18. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 2007;7:249-57.
19. Reed JC. Dysregulation of apoptosis in cancer. J Clin Oncol 1999;17:2941-53. (Pubitemid 29415256)
20. Korsmeyer SJ. BCL-2 gene family and the regulation of programmed cell death. Cancer Res 1999;59:1693s-700.