Cyclophosphamide and ascorbic acid-mediated ultrastructural and biochemical changes in Dalton's lymphoma cells in vivo

European Journal of Pharmacology

Volumn 645, Issue 1-3, 2010, Pages 47-54

  Prasad, Surya Bali ^a   Rosangkima, Gabriel ^a   Nicol, Bonnie M ^a  

^a NORTH EASTERN HILL UNIVERSITY   (India)

Author keywords

Ascorbic acid; Cyclophosphamide; Dalton's lymphoma; Glutathione; Lactate dehydrogenase

Indexed keywords

ASCORBIC ACID; CYCLOPHOSPHAMIDE; GLUTATHIONE; LACTATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DEATH; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SHAPE; CELL SURFACE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; LYMPHOMA; LYMPHOMA CELL; MITOCHONDRION; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; STRUCTURE ANALYSIS; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ASCITES; ASCORBIC ACID; CYCLOPHOSPHAMIDE; FEMALE; GLUTATHIONE; L-LACTATE DEHYDROGENASE; LYMPHOMA, T-CELL; MALE; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; NEOPLASM TRANSPLANTATION; TUMOR CELLS, CULTURED;

EID: 77956191052     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.07.020     Document Type: Article

References (54)

1. Abraham P., Kanakasabapathy I., Kulothungan P. Alterations in antioxidant enzyme activities and increased oxidative stress in cyclophosphamide-induced hemorrhagic cystitis in the rat. Cancer Ther. 2008, 6:563-570.
2. Arismendi-Morillo G. Electron microscopy morphology of the mitochondrial network in human cancer. Int. J. Biochem. Cell Biol. 2009, 41(10):2062-2068.
3. Ayhanci A., Uyar R., Aral E., Kabadere S., Appak S. Protective effect of zinc on cyclophosphamide-induced hematoxicity and urotoxicity. Biol. Trace Elem. Res. 2008, 126:186-193.
4. Brady H.R., Kone B.C., Stromski M.E., Zeidel M.L., Giebisch G., Gullans S.R. Mitochondrial injury: an early event in cisplatin toxicity to renal proximal tubules. Am. J. Physiol. 1990, 258:F1181-F1187.
5. Cameron E., Pauling L. Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc. Natl. Acad. Sci. 1976, 73:3685-3689.
6. Chen L.H., Boissonneault G.A., Glaurert H.P. Vitamin C, vitamin E and cancer. Anticancer Res. 1988, 8:739-748.
7. Czyzewska A., Mazur L. Suppressing effect of WR-2721 on micronuclei induced by cyclophosphamide in mice. Teratog. Carcinog. Mutagen. 1995, 15:109-114.
8. Dhar-Mascareno M., Carcamo J.M., Golde D.W. Hypoxia-reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C. Free Radic. Biol. Med. 2005, 38:1311-1322.
9. Erat M., Ciftci M., Gumustekin K., Gul M. Effects of nicotine and vitamin E on glutathione reductase activity in some rat tissue in vivo and in vitro. Eur. J. Pharmacol. 2007, 554:92-97.
10. Fotakis G., Timbrell J.A. In vitro cytotoxicity assays: comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol. Lett. 2006, 160:171-177.
11. Fraiser L.H., Kanekal S., Kehrer J.P. Cyclophosphamide toxicity. Characterizing and avoiding the problem. Drug 1991, 42:781-795.
12. Giles G.I. The redox regulation of thiol dependent signaling pathways in cancer. Curr. Pharm. Des. 2006, 12:4427-4443.
13. Giri A., Khianriam D., Prasad S.B. Vitamin C mediated protection against cisplatin induced mutagenicity in mice. Mutat. Res. 1998, 421:139-148.
14. Goldie H., Felix M.D. Growth characteristics of free tumor cells transformed serially in the peritoneal fluid of the mouse. Cancer Res. 1951, 11:73-80.
15. Gonzalez M.J., Mora E., Riordan N.H., Riordan H.D., Mojica P. Rethinking vitamin C and cancer: an update on nutritional oncology. Cancer Prev. Int. 1998, 3:215-224.
16. Hanck A.B. Vitamin C and cancer. Prog. Clin. Biol. Res. 1988, 259:307-320.
17. Hempel N., Ye H., Abessi B., Mian B., Melendez J.A. Altered redox status accompanies progression to metastatic human bladder cancer. Free Radic. Biol. Med. 2009, 46(1):42-50.
18. Huang J., May J.M. Ascorbic acid protects SH-SY5Y neuroblastoma cells from apoptosis and death induced by beta-amyloid. Brain Res. 2006, 1097:52-58.
19. Hui M.K.C., Wu W.K.K., Shin V.Y., So W.H.L., Cho C.H. Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice. Int. J. Med. Sci. 2006, 3:1-6.
20. Jansson P.J., Lindqvist C., Nordstrom T. Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water. Free Radic. Res. 2005, 39:1233-1239.
21. Kang Y.H., Park S.H., Lee Y.J., Kang J.S., Kang I.J., Shin H.K., Park J.H., Bunger R. Antioxidant alpha-ketocarboxylate pyruvate protects low-density lipoprotein and atherogenic macrophages. Free Radic. Res. 2002, 36:905-914.
22. Khan T.S., Sundin A., Juhlin C.F., Wilander E., Oberg K., Eriksson B. Vincristine, cisplatin, teniposide, and cyclophosphamide combination in the treatment of recurrent or metastatic adrenocortical cancer. Med. Oncol. 2004, 21:167-178.
23. Khynriam D., Prasad S.B. Changes in endogenous tissue glutathione level in relation to murine ascites tumor growth and the anticancer activity of cisplatin. Braz. J. Med. Biol. Res. 2003, 36:53-63.
24. ++ in cisplatin-induced cell injury in rabbit renal cortical slices. Toxicol. Appl. Pharm. 1997, 146:261-269.
25. Koukourakis M.I., Kontomanolis E., Giatromanolaki A., Sivridis E., Liberis V. Serum and tissue LDH levels in patients with breast/gynaecological cancer and benign diseases. Gynecol. Obstet. Investig. 2009, 67:162-168.
26. Langford C.A. Complications of cyclophosphamide therapy. Eur. Arch. Otorhinolaryngol. 1997, 254:65-72.
27. Lemasters J.J., Guiseppi J.D., Nieminen A.L., Herman B. Blebbing, free calcium and mitochondrial membrane potential preceding cell death in hepatocytes. Nature 1987, 325:78-80.
28. Loke W.M., Proudfoot J.M., McKinley A.J., Croft K.D. Augmentation of monocyte intracellular ascorbate in vitro protects cells from oxidative damage and inflammatory responses. Biochem. Biophys. Res. Commun. 2006, 345:1039-1043.
29. Matés J.M., Segura J.A., Alonso F.J., Márquez J. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch. Toxicol. 2008, 82:273-299.
30. McCall M.R., Frei B. Can antioxidant vitamins materially reduce oxidative damage in humans? Free Rad. Biol. Méd. 1999, 26:1034-1053.
31. Meister A., Anderson M.E. Glutathione. Annu. Rev. Biochem. 1983, 52:711-760.
32. Melendez-Zajgla J., Cruz E., Maldonado V., Espinoza A.N. Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin. Biochem. Mol. Biol. Int. 1999, 47:765-771.
33. Mikino Y., Sakagami H., Takeda M. Induction of cell death by ascorbic acid derivatives in human renal carcinoma and glioblastoma cell lines. Anticancer Res. 1999, 19:3125-3132.
34. Murphy M.P., Smith R.A.J. Drug delivery to mitochondria: the key to mitochondrial medicine. Adv. Drug Deliv. Rev. 2000, 41:235-250.
35. Nagy B., Mucsi I., Molnar J., Varga A., Thurzo L. Chemosensitizing effect of vitamin C in combination with 5-fluorouracil in vitro. In Vivo 2003, 17:289-292.
36. Navarro J., Obrador E., Carretero J., Petschen I., Avino J., Perez P., Estrela J.M. Changes in glutathione status and the antioxidant system in blood and in cancer cells associated with tumour growth in vivo-modulation by the rate of cellular proliferation and inhibition of cancer growth. Free Radic. Biol. Med. 1999, 26:410-418.
37. Nicol B.M., Prasad S.B. Sialic acid changes in Dalton's lymphoma-bearing mice after cyclophosphamide and cisplatin treatment. Braz. J. Med. Biol. Res. 2002, 35:549-553.
38. Nicol B.M., Prasad S.B. The effects of cyclophosphamide alone and in combination with ascorbic acid against murine ascites Dalton's lymphoma. Indian J. Pharmacol. 2006, 38:260-265.
39. Omaye S.T., Turnbull J.D., Sauberlich H.E. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods in Enzymology 1979, 62(part D):3-12. Academic press, New York. D.B. McCormick, L.D. Wright (Eds.).
40. Pessayre D., Mansouri A., Haouzi D., Fromenty B. Hepato-toxicity due to mitochondrial dysfunction. Cell Biol. Toxicol. 2000, 15:367-373.
41. Ramp W.K., Thorton P.A. The effects of ascorbic acid on the glycolytic and respiratory metabolism of embryonic chick tibias. Calcif. Tissue Res. 1968, 2:77-82.
42. Rossig L., Hoffmann J., Hugel B., Mallat Z., Haase A., Freyssinet J.M., Tedgui A., Aicher A., Zeiher A.M., Dimmeler S. Vitamin C inhibits endothelial cell apoptosis in congestive heart failure. Circulation 2001, 104:2182-2187.
43. Saeed R.W., Peng T., Metz C.N. Ascorbic acid blocks the growth inhibitory effect of tumor necrosis factor-alpha on endothelial cells. Exp. Biol. Med. 2003, 228:855-865.
44. Sakagami H., Satoh K. Pro-oxidant action of two antioxidants: ascorbic acid and gallic acid. Anticancer Res. 1997, 17:221-224.
45. Schnelldorfer T., Gansauge S., Gansauge F., Schlosser S., Beger H.G., Nussler A.K. Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells. Cancer 2000, 89:1440-1447.
46. Sedlak J., Lindsay R.H. Estimation of total, protein-bound and non protein sulphydryl groups in tissue with Ellman's reagent. Anal. Biochem. 1968, 25:192-205.
47. Taper H.S., DeGerlache J., Lans M., Roberfroid M. Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pre-treatment. Int. J. Cancer 1987, 40:575-579.
48. Terradez P., Asensi M., Lasso De La Vega M.C., Puertes I.R., Vina J., Estrela J.M. Depletion of tumour glutathione in vivo by buthionine sulphoximine: modulation by the rate of cellular proliferation and inhibition of cancer growth. Biochem. J. 1993, 292:477-483.
49. Tsai-Turton M., Luong B.T., Tan Y., Luderer U. Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion. Toxicol. Sci. 2007, 98:216-230.
50. Vorhaben J.E., Campbell J.W. Glutamine synthetase: a mitochondrial enzyme in uricotelic species. J. Biol. Chem. 1972, 247:2763-2767.
51. Wang W., Ballatori N. Endogenous glutathione conjugates: occurrence and biological functions. Pharmacol. Rev. 1998, 50:335-355.
52. White M.T., Ayra D.V., Tewari K.K. Biochemical properties of neoplastic cell mitochondria. J. Natl. Cancer I 1974, 53:553-559.
53. Wood K.A., Youle R.J. Apoptosis and free radicals. Ann. N.Y. Acad. Sci. 1994, 738:400-407.
54. Zubkova E.V., Robaire B. Effect of glutathione depletion on antioxidant enzymes in the epididymis, seminal vesicles, and liver and on spermatozoa motility in the aging brown Norway rat. Biol. Reprod. 2004, 71:1002-1008.