Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 10, 2008, Pages 1364-1368

  Jemaa, Riadh ^a   Achouri, Afef ^a   Kallel, Amani ^a   Ali, Samir Ben ^a   Mourali, Sami ^a   Feki, Moncef ^a   Elasmi, Monia ^a   Taieb, Samah Haj ^a   Sanhaji, Haïfa ^a   Omar, Souheil ^a   Mechmeche, Rachid ^a   Kaabachi, Naziha ^a  

^a LA RABTA HOSPITAL   (Tunisia)

Author keywords

Homocysteine; Methionine synthase; MTR; Myocardial infarction; Polymorphism

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE SYNTHASE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CIGARETTE SMOKING; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DNA DETERMINATION; DYSLIPIDEMIA; FOLIC ACID BLOOD LEVEL; GENE EXPRESSION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEART INFARCTION; HUMAN; HYPERTENSION; IMMUNOFLUORESCENCE TEST; MAJOR CLINICAL STUDY; MALE; MICROPARTICLE ENZYME IMMUNOASSAY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TUNISIA; VITAMIN BLOOD LEVEL;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; FEMALE; FOLIC ACID; GENE FREQUENCY; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; MUTATION; MYOCARDIAL INFARCTION; TUNISIA; VITAMIN B 12;

EID: 53849108777     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.306     Document Type: Article

References (27)

1. Den-Heijer M, Rosendaal FR, Blom HJ, Gerrits WB, Bos GM. Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb Haemost 1998;80:874-7.
2. Ueland PM, Refsum H, Beresford SA, Vollset SE. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr 2000;72:324-32.
3. Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, et al. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet 1996;5:1867-74.
4. Chen LH, Liu ML, Hwang HY, Chen LS, Korenberg J, Shane B. Human methionine synthase. CDNA cloning, gene localization, and expression. J Biol Chem 1997;272:3628-34.
5. Matthews RG, Sheppard C, Goulding C. Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology. Eur J Pediatr 1998;157(Suppl 2):S54-9.
6. Van der Put NM, van der Molen EF, Kluijtmans LA, Heil SG, Trijbels JM, Eskes TK, et al. Sequence analyses of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural tube defects and vascular disease. Q J Med 1997;90:511-7.
7. Harmon DL, Shields DC, Woodside JV, McMaster D, Yarnell JW, Young IS, et al. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol 1999;17:298-309.
8. Tsai MY, Bignell M, Yang F, Welge BG, Graham KJ, Hanson NQ. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine β-synthase and A2756G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis 2000;149:131-7.
9. Dekou V, Gudnason V, Hawe E, Miller GJ, Stanbie D, Humphries SE. Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men. Thromb Haemost 2001;85:67-74.
10. Chen J, Stampfer MJ, Ma J, Selhub J, Malinow MR, Hennekens CH, et al. Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis 2001;154:667-72.
11. Wang XL, Duarte N, Cai H, Adachi T, Sim AS, Cranney G, et al. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. Atherosclerosis 1999;146:133-40.
12. Morita H, Kurihara H, Sugiyama T, Hamada C, Kurihara Y, Shindo T, et al. Polymorphism of the methionine synthase gene: association with homocysteine metabolism and late-onset vascular diseases in the Japanese population. Arterioscler Thromb Vasc Biol 1999;19:298-302.
13. Tsai MY, Welge BG, Hanson NQ, Bignell MK, Vessey J, Schwichtenberg K, et al. Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases. Atherosclerosis 1999;43:163-70.
14. Ma J, Stampfer MJ, Christensen B, Giovannucci E, Hunter DJ, Chen J, et al. A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocysteine, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 1999;8:825-9.
15. D'Angelo A, Coppola A, Madonna P, Fermo I, Pagano A, Mazzola G, et al. The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost 2000;83:563-70.
16. Hyndman ME, Bridge PJ, Warnica JW, Fick G, Parsons HG. Effect of heterozygosity for the methionine synthase 2756A→G mutation on the risk of recurrent cardiovascular disease events. Am J Cardiol 2000;86:1144-6.
17. World Health Organization. Physical status: the use and interpretation of anthropometry: report of a WHO expert committee. WHO Techn Rep Ser 1995;854:321-44.
18. National Institutes of Health, National Heart, Lung and Blood Institute Obesity Education Initiative. Expert panel on the identification, evaluation, and treatment of overweight and obesity in adults, 1998.
19. Marcadet A, O'Connel P, Cohen D. Standardized Southern blot workshop techniques. In: Dupont B, editor. Histocompatibility testing. New York: Springer, 1987:587-90.
20. Faucher C, Nivet-Antoine V, Myara J, Durand D. Technique d'étude de quatre polymorphismes enzymatiques impliqués dans l'hyperhomocystéinémie. Immuno-Anal Biol Spécial 2002;17:251-6.
21. Rozen R. Polymorphisms of folate and cobalamin metabolism. In: Carnel R, Jacobsen DW, editors. Homocysteine in health and disease. Cambridge: Cambridge University Press, 2001:259-70.
22. Geisel J, Zimbelmann I, Schorr H, Knapp JP, Bodis M, Hubner U, et al. Genetic defects as important factors for moderate hyperhomocysteinemia. Clin Chem Lab Med 2001;39:698-704.
23. Klerk M, Lievers KJ, Kluijtmans LA, Blom HJ, den Heijer M, Schouten EG, et al. The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. Thromb Res 2003;110:87-91.
24. Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M. Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c→t methylenetetrahydrofolate reductase and 2756a→g methionine synthase genotypes. Mol Genet Metab 2000;70:27-44.
25. Wang XL, Cai H, Cranney G, Wilcken DE. The frequency of a common mutation of the methionine synthase gene in the Australian population and its relation to smoking and coronary artery disease. J Cardiovasc Risk 1998;5:289-95.
26. Carvo ML, Camilo ME. Hyperhomocysteinemia is chronic alcoholism: relations to folic acid and vitamin B(6) and B(12) status. Nutrition 2000;16:296-302.
27. Laraqui A, Allami A, Carrié A, Raisonnier A, Coiffard AS, Benkouka F, et al. Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease. Eur J Intern Med 2007;18:474-83.