Epidemiology and clinical characteristics of Clostridium difficile infection in a Korean tertiary hospital

Journal of Korean Medical Science

Volumn 26, Issue 10, 2011, Pages 1258-1264

  Kim, Jieun ^a   Pai, Hyunjoo ^a   Seo, Mi ran ^a   Kang, Jung Oak ^a  

^a Hanyang University College of Medicine   (South Korea)

Author keywords

Clinical characteristics; Clostridium difficile infection; Incidence; Toxin type

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL TOXIN; ENTEROTOXIN; METRONIDAZOLE; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE; VANCOMYCIN;

AGED; ARTICLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTION; DIARRHEA; FECES; FEMALE; HOSPITAL; HUMAN; INCIDENCE; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; PSEUDOMEMBRANOUS COLITIS; RECURRENT DISEASE; SOUTH KOREA; TREATMENT OUTCOME;

AGED; BACTERIAL PROTEINS; BACTERIAL TOXINS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DIARRHEA; ENTEROCOLITIS, PSEUDOMEMBRANOUS; ENTEROTOXINS; FECES; FEMALE; HOSPITALS; HUMANS; INCIDENCE; MALE; METRONIDAZOLE; MIDDLE AGED; PROSPECTIVE STUDIES; RECURRENCE; REPUBLIC OF KOREA; TREATMENT OUTCOME; VANCOMYCIN;

EID: 84863012481     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2011.26.10.1258     Document Type: Article

References (30)

1. Kelly CP, LaMont JT. Clostridium difficile: more difficult than ever. N Engl J Med 2008; 359: 1932-40.
2. Pepin J, Valiquette L, Alary ME, Villemure P, Pelletier A, Forget K, Pepin K, Chouinard D. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. CMAJ 2004; 171: 466-72.
3. Lee YJ, Choi MG, Lim CH, Jung WR, Cho HS, Sung HY, Nam KW, Chang JH, Cho YK, Park JM, Kim SW, Chung IS. Change of Clostridium difficile colitis during recent 10 years in Korea. Korean J Gastroenterol 2010; 55:169-74.
4. Shin BM, Kuak EY, Yoo HM, Kim EC, Lee K, Kang JO, Whang DH, Shin JH. Multicentre study of the prevalence of toxigenic Clostridium difficile in Korea: results of a retrospective study 2000-2005. J Med Microbiol 2008; 57: 697-701.
5. McFarland LV. Epidemiology, risk factors and treatments for antibioticassociated diarrhea. Dig Dis 1998; 16: 292-307.
6. Gravel D, Miller M, Simor A, Taylor G, Gardam M, McGeer A, Hutchinson J, Moore D, Kelly S, Boyd D, Mulvey M; Canadian Nosocomial Infection Surveillance Program. Health care-associated Clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian Nosocomial Infection Surveillance Program Study. Clin Infect Dis 2009; 48: 568-76.
7. O'Connor JR, Johnson S, Gerding DN. Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology 2009; 136: 1913-24.
8. World Health Organisation. The anatomical therapeutic chemical (ATC) and defined daily dosing (DDD) system index 2010. Available at: http://www.whocc.no/[accessed on 28 Oct 2010].
9. Zar FA, Bakkanagari SR, Moorthi KM, Davis MB. A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity. Clin Infect Dis 2007; 45:302-7.
10. Louie T, Miller M, Donskey C, Mullane K, Goldstein EJ. Clinical outcomes, safety, and pharmacokinetics of OPT-80 in a phase 2 trial with patients with Clostridium difficile infection. Antimicrob Agents Chemother 2009; 53: 223-8.
11. Barbut F, Richard A, Hamadi K, Chomette V, Burghoffer B, Petit JC. Epidemiology of recurrences or reinfections of Clostridium difficile-associated diarrhea. J Clin Microbiol 2000; 38: 2386-8.
12. Aspinall ST, Hutchinson DN. New selective medium for isolating Clostridium difficile from faeces. J Clin Pathol 1992; 45: 812-4.
13. Persson S, Torpdahl M, Olsen KE. New multiplex PCR method for the detection of Clostridium difficile toxin A (tcdA) and toxin B (tcdB) and the binary toxin (cdtA/cdtB) genes applied to a Danish strain collection. Clin Microbiol Infect 2008; 14: 1057-64.
14. Rupnik M, Braun V, Soehn F, Janc M, Hofstetter M, Laufenberg-Feldmann R, von Eichel-Streiber C. Characterization of polymorphisms in the toxin A and B genes of Clostridium difficile. FEMS Microbiol Lett 1997; 148: 197-202.
15. Tae CH, Jung SA, Song HJ, Kim SE, Choi HJ, Lee M, Hwang Y, Kim H, Lee K. The first case of antibiotic-associated colitis by Clostridium difficile PCR ribotype 027 in Korea. J Korean Med Sci 2009; 24: 520-4.
16. Lee JH, Lee SY, Kim YS, Park SW, Jo SY, Ryu SH, Lee JH, Moon JS, Whang DH, Shin BM. The incidence and clinical features of Clostridium difficile infection; single center study. Korean J Gastroenterol 2010; 55: 175-82.
17. Byun TJ, Han DS, Ahn SB, Cho HS, Kim TY, Eun CS, Jeon YC, Sohn JH, Kang JO. Clinical characteristics and changing epidemiology of Clostridium difficile-associated disease (CDAD). Korean J Gastroenterol 2009; 54: 13-9.
18. Jung KS, Park JJ, Chon YE, Jung ES, Lee HJ, Jang HW, Lee KJ, Lee SH, Moon CM, Lee JH, Shin JK, Jeon SM, Hong SP, Kim TI, Kim WH, Cheon JH. Risk factors for treatment failure and recurrence after metronidazole treatment for Clostridium difficile-associated diarrhea. Gut Liver 2010; 4: 332-7.
19. Cheong HS, Kim JK, Kwon KT, Ryu SY, Heo ST, Ko KS, Oh WS, Peck KR, Lee NY, Song JH. Therapeutic efficacy of metronidazole for patients with Clostridium difficile-associated diarrhea. Korean J Med 2007; 72: 639-46.
20. Belmares J, Johnson S, Parada JP, Olson MM, Clabots CR, Bettin KM, Peterson LR, Gerding DN. Molecular epidemiology of Clostridium difficile over the course of 10 years in a tertiary care hospital. Clin Infect Dis 2009; 49: 1141-7.
21. Barbut F, Gariazzo B, Bonne L, Lalande V, Burghoffer B, Luiuz R, Petit JC. Clinical features of Clostridium difficile-associated infections and molecular characterization of strains: results of a retrospective study, 2000-2004. Infect Control Hosp Epidemiol 2007; 28: 131-9.
22. Riggs MM, Sethi AK, Zabarsky TF, Eckstein EC, Jump RL, Donskey CJ. Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis 2007; 45: 992-8.
23. Kyne L, Warny M, Qamar A, Kelly CP. Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med 2000; 342: 390-7.
24. Kim H, Jeong SH, Roh KH, Hong SG, Kim JW, Shin MG, Kim MN, Shin HB, Uh Y, Lee H, Lee K. Investigation of toxin gene diversity, molecular epidemiology, and antimicrobial resistance of Clostridium difficile isolated from 12 hospitals in South Korea. Korean J Lab Med 2010; 30: 491-7.
25. Kim H, Riley TV, Kim M, Kim CK, Yong D, Lee K, Chong Y, Park JW. Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea: impact on laboratory diagnosis. J Clin Microbiol 2008; 46: 1116-7.
26. Iwashima Y, Nakamura A, Kato H, Wakimoto Y, Wakiyama N, Kaji C, Ueda R. A retrospective study of the epidemiology of Clostridium difficile infection at a University Hospital in Japan: genotypic features of the isolates and clinical characteristics of the patients. J Infect Chemother 2010; 16: 329-33.
27. Huang H, Wu S, Wang M, Zhang Y, Fang H, Palmgren AC, Weintraub A, Nord CE. Clostridium difficile infections in a Shanghai hospital: antimicrobial resistance, toxin profiles and ribotypes. Int J Antimicrob Agents 2009; 33: 339-42.
28. Elliott B, Squire MM, Thean S, Chang BJ, Brazier JS, Rupnik M, Riley TV. New types of toxin A-negative, toxin B-positive strains among clinical isolates of Clostridium difficile in Australia. J Med Microbiol 2011; 60: 1108-11.
29. Huang H, Fang H, Weintraub A, Nord CE. Distinct ribotypes and rates of antimicrobial drug resistance in Clostridium difficile from Shanghai and Stockholm. Clin Microbiol Infect 2009; 15: 1170-3.
30. Pepin J, Saheb N, Coulombe MA, Alary ME, Corriveau MP, Authier S, Leblanc M, Rivard G, Bettez M, Primeau V, Nguyen M, Jacob CE, Lanthier L. Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis 2005; 41: 1254-60.