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Volumn 32, Issue 2, 2012, Pages 216-222

Use of functional genomics to identify candidate genes underlying human genetic association studies of vascular diseases

Author keywords

coronary artery disease; coronary heart disease; expression quantitative trait loci; functional genomics; genome wide association study

Indexed keywords

FUNCTIONAL GENOMICS; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; POPULATION GENETICS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; VASCULAR DISEASE;

EID: 84862946297     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.232702     Document Type: Review
Times cited : (19)

References (60)
  • 1
    • 66349118643 scopus 로고    scopus 로고
    • A systems-based framework for understanding complex metabolic and cardiovascular disorders
    • Wu S, Lusis AJ, Drake TA. A systems-based framework for understanding complex metabolic and cardiovascular disorders. J Lipid Res. 2009;50(suppl):S358-S363.
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Wu, S.1    Lusis, A.J.2    Drake, T.A.3
  • 4
    • 77954407332 scopus 로고    scopus 로고
    • Genomewide association studies and assessment of the risk of disease
    • Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med. 2010;363:166-176.
    • (2010) N Engl J Med , vol.363 , pp. 166-176
    • Manolio, T.A.1
  • 7
    • 33750200729 scopus 로고    scopus 로고
    • Cis-Regulatory variations: A study of SNPs around genes showing cislinkage in segregating mouse populations
    • GuhaThakurta D, Xie T, Anand M, Edwards SW, Li G, Wang SS, Schadt EE. cis-Regulatory variations: a study of SNPs around genes showing cislinkage in segregating mouse populations. BMC Genomics. 2006;7:235.
    • (2006) BMC Genomics , vol.7 , pp. 235
    • Guhathakurta, D.1    Xie, T.2    Anand, M.3    Edwards, S.W.4    Li, G.5    Wang, S.S.6    Schadt, E.E.7
  • 8
    • 33646841491 scopus 로고    scopus 로고
    • Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes
    • Lum PY, Chen Y, Zhu J, Lamb J, Melmed S, Wang S, Drake TA, Lusis AJ, Schadt EE. Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes. J Neurochem. 2006;97(suppl 1):50-62.
    • (2006) J Neurochem , vol.97 , Issue.SUPPL. 1 , pp. 50-62
    • Lum, P.Y.1    Chen, Y.2    Zhu, J.3    Lamb, J.4    Melmed, S.5    Wang, S.6    Drake, T.A.7    Lusis, A.J.8    Schadt, E.E.9
  • 9
    • 16244378266 scopus 로고    scopus 로고
    • Identification of candidate genes in the type 2 diabetes modifier locus using expression Q.T.L
    • Yaguchi H, Togawa K, Moritani M, Itakura M. Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL. Genomics. 2005;85:591-599.
    • (2005) Genomics , vol.85 , pp. 591-599
    • Yaguchi, H.1    Togawa, K.2    Moritani, M.3    Itakura, M.4
  • 11
    • 28044448688 scopus 로고    scopus 로고
    • Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice
    • Drake TA, Schadt EE, Davis RC, Lusis AJ. Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice. Am J Ther. 2005;12:503-511.
    • (2005) Am J Ther , vol.12 , pp. 503-511
    • Drake, T.A.1    Schadt, E.E.2    Davis, R.C.3    Lusis, A.J.4
  • 14
    • 33750204290 scopus 로고    scopus 로고
    • Genetics of global gene expression
    • Rockman MV, Kruglyak L. Genetics of global gene expression. Nat Rev Genet. 2006;7:862-872.
    • (2006) Nat Rev Genet , vol.7 , pp. 862-872
    • Rockman, M.V.1    Kruglyak, L.2
  • 15
    • 0037177625 scopus 로고    scopus 로고
    • Genetic dissection of transcriptional regulation in budding yeast
    • Brem RB, Yvert G, Clinton R, Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast. Science. 2002;296:752-755.
    • (2002) Science , vol.296 , pp. 752-755
    • Brem, R.B.1    Yvert, G.2    Clinton, R.3    Kruglyak, L.4
  • 17
    • 73949149600 scopus 로고    scopus 로고
    • EQTL analysis in mice and rats
    • Tesson BM, Jansen RC. eQTL analysis in mice and rats. Methods Mol Biol. 2009;573:285-309.
    • (2009) Methods Mol Biol , vol.573 , pp. 285-309
    • Tesson, B.M.1    Jansen, R.C.2
  • 34
    • 84872923607 scopus 로고    scopus 로고
    • Genomics of ADME gene expression: Mapping expression quantitative trait loci relevant for absorption distribution metabolism and excretion of drugs in human liver [epub ahead of print October 18]
    • Schroder A, Klein K, Winter S, Schwab M, Bonin M, Zell A, Zanger UM. Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver [epub ahead of print October 18]. Pharmacogenomics J. 2011.
    • (2011) Pharmacogenomics J
    • Schroder, A.1    Klein, K.2    Winter, S.3    Schwab, M.4    Bonin, M.5    Zell, A.6    Zanger, U.M.7
  • 40
    • 74249100914 scopus 로고    scopus 로고
    • Fine-scale variation and genetic determinants of alternative splicing across individuals
    • Coulombe-Huntington J, Lam KC, Dias C, Majewski J. Fine-scale variation and genetic determinants of alternative splicing across individuals. PLoS Genet. 2009;5:e1000766.
    • (2009) PLoS Genet , vol.5
    • Coulombe-Huntington, J.1    Lam, K.C.2    Dias, C.3    Majewski, J.4
  • 50
    • 77954238686 scopus 로고    scopus 로고
    • Allele-specific methylation is prevalent and is contributed by CPG-SNPs in the human genome
    • Shoemaker R, Deng J, Wang W, Zhang K. Allele-specific methylation is prevalent and is contributed by CPG-SNPs in the human genome. Genome Res. 2010;20:883-889.
    • (2010) Genome Res , vol.20 , pp. 883-889
    • Shoemaker, R.1    Deng, J.2    Wang, W.3    Zhang, K.4
  • 52
    • 80053901650 scopus 로고    scopus 로고
    • A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS
    • Richardson K, Lai CQ, Parnell LD, Lee YC, Ordovas JM. A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS. BMC Genomics. 2011;12:504.
    • (2011) BMC Genomics , vol.12 , pp. 504
    • Richardson, K.1    Lai, C.Q.2    Parnell, L.D.3    Lee, Y.C.4    Ordovas, J.M.5
  • 54
    • 33746393852 scopus 로고    scopus 로고
    • Influence of human genome polymorphism on gene expression
    • Pastinen T, Ge B, Hudson TJ. Influence of human genome polymorphism on gene expression. Hum Mol Genet. 2006;15(spec no 1):R9-R16.
    • (2006) Hum Mol Genet , vol.15 , Issue.SPEC NO. 1
    • Pastinen, T.1    Ge, B.2    Hudson, T.J.3
  • 56
    • 77950339092 scopus 로고    scopus 로고
    • Integrating pathway analysis and genetics of gene expression for genome-wide association studies
    • Zhong H, Yang X, Kaplan LM, Molony C, Schadt EE. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet. 2010;86:581-591.
    • (2010) Am J Hum Genet , vol.86 , pp. 581-591
    • Zhong, H.1    Yang, X.2    Kaplan, L.M.3    Molony, C.4    Schadt, E.E.5
  • 60
    • 79151484424 scopus 로고    scopus 로고
    • The study of eQTL variations by RNA-SEQ: From SNPs to phenotypes
    • Majewski J, Pastinen T. The study of eQTL variations by RNA-SEQ: from SNPs to phenotypes. Trends Genetics. 2011;27:72-79.
    • (2011) Trends Genetics , vol.27 , pp. 72-79
    • Majewski, J.1    Pastinen, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.